The effect of the composition of leuzea and cranberry meal extracts on testosterone level in mice

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Abstract

BACKGROUND: Current research suggests the potential use of natural components as sources of anabolic compounds. One of these is a new composition of leuzea and cranberry meal extracts, which, as was found earlier, exhibits a dose-dependent anabolic effect.

AIM: To establish the supposed mechanism of the anabolic effect in the composition of leuzea and cranberry meal extracts.

MATERIALS AND METHODS: In the experiment, CD-1 mice of both sexes weighing 20–25 g were used. All animals were measured blood testosterone concentration in dynamics: 0 point (before the administration of the analyzed compositions), 30, 60, 120, 180 minutes after administration.

RESULTS: After a single administration of the composition of leuzea and cranberry meal extracts at a dose of 70+500 mg/kg, the level of testosterone in the blood mice of both sexes increases, and the increase in testosterone levels in females is less pronounced than in males.

CONCLUSIONS: One of the supposed mechanisms of the anabolic effect in the composition, characterized by an increase in blood testosterone levels, has been established.

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About the authors

Daria A. Khalikova

Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science

Email: dasha.halikova@mail.ru
ORCID iD: 0000-0002-3932-2491

Postgraduate at the Laboratory of Pharmacological Research

Russian Federation, 9, Academician Lavrentiev Ave., Novosibirsk, 630090

Sergey V. Ankov

Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science

Email: sergey.ankov42@gmail.com
ORCID iD: 0000-0001-5588-8420

Cand. Sci. (Biol.), Research Associate of the Laboratory of Pharmacological Research

Russian Federation, 9, Academician Lavrentiev Ave., Novosibirsk, 630090

Julia V. Meshkova

Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science

Author for correspondence.
Email: meshkova_29@mail.ru
ORCID iD: 0000-0002-5935-2540

Junior Researcher of the Laboratory of Pharmacological Research

Russian Federation, 9, Academician Lavrentiev Ave., Novosibirsk, 630090

Tatiana G. Tolstikova

Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science

Email: tg_tolstikova@mail.ru
ORCID iD: 0000-0002-3750-2958

Dr. Sci. (Biol.), Professor, Head of the Laboratory of Pharmacological Research

Russian Federation, 9, Academician Lavrentiev Ave., Novosibirsk, 630090

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2. Fig. 1. Area under the curve (AUC). The level of testosterone in the blood of female mice CD-1 after a single injection in the intact group (a), extract of leuzea + extract of cranberry meal 70+500 mg/kg (b), extract of leuzea 70 mg/kg (c), extract of cranberry meal 500 mg/kg (d); * p < 0.05 — significance level compared to intact group (a)

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3. Fig. 2. Area under the curve (AUC). The level of testosterone in the blood of male mice CD-1 after a single injection in the intact group (a), extract of leuzea + extract of cranberry meal 70+500 mg/kg (b), extract of leuzea 70 mg/kg (c), extract of cranberry meal 500 mg/kg (d); * р < 0.05 — significance level compared to intact group (a), ** р < 0.005

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Copyright (c) 2021 Khalikova D.A., Ankov S.V., Meshkova J.V., Tolstikova T.G.

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