Fructose-fed model of the metabolic syndrome: pathogenetic relationships between metabolic disorders



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Abstract

The results of modeling of metabolic syndrome in 25 male Wistar rats (140-180 g), fed a standard diet and 10% fructose solution in drinking water for 6 weeks, are presented. Animals in control group (n = 14) consumed standard diet and plain water. It is shown, that fructose feeding in rats for 6 weeks contributes to development of the initial stages of the metabolic syndrome (hyperglycemia and visceral obesity). Nonesterified fatty acids and uric acid play a certain role in pathogenesis of the metabolic syndrome. Presumably, it is necessary to use higher doses of fructose for a longer time for the development of classic fructose-induced metabolic syndrome with hyperuricemia.

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About the authors

M V Reshetnyak

The Federal State Institute of Public Health «The Nikiforov Russian Center of Emergency and Radiation Medicine», St. Petersburg; Institute of Cytology Russian Academy of Science, St. Petersburg

Email: reshetnyak.m@mail.ru

V N Khirmanov

The Federal State Institute of Public Health «The Nikiforov Russian Center of Emergency and Radiation Medicine», St. Petersburg; Institute of Cytology Russian Academy of Science, St. Petersburg

N N Zybina

The Federal State Institute of Public Health «The Nikiforov Russian Center of Emergency and Radiation Medicine», St. Petersburg; Institute of Cytology Russian Academy of Science, St. Petersburg

M Y Frolova

The Federal State Institute of Public Health «The Nikiforov Russian Center of Emergency and Radiation Medicine», St. Petersburg; Institute of Cytology Russian Academy of Science, St. Petersburg

G A Sakuta

The Federal State Institute of Public Health «The Nikiforov Russian Center of Emergency and Radiation Medicine», St. Petersburg; Institute of Cytology Russian Academy of Science, St. Petersburg

B N Kudryavtsev

The Federal State Institute of Public Health «The Nikiforov Russian Center of Emergency and Radiation Medicine», St. Petersburg; Institute of Cytology Russian Academy of Science, St. Petersburg

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Copyright (c) 2011 Reshetnyak M.V., Khirmanov V.N., Zybina N.N., Frolova M.Y., Sakuta G.A., Kudryavtsev B.N.

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