Theoretical background of concept of perfusion rehabilitation of donor organs



Cite item

Full Text

Abstract

The article dedicated to the main problem of transplantology which is deficit of acceptable donors'organs. The tendency of expanding the donor's pool should include policy of prevention and reduction the ischemia-reperfusion trauma of donor's organs. The crucial role of machine perfusion in pretransplantaion improving organs quality is highlighted. The large review of literature is listed in order to state several new approaches in modern preservation trend. The definition of organ preservation is given as well as new strategy in organ acceptance is grounded.

Full Text

Restricted Access

About the authors

S F Bagnenko

I.I. Djanelidze State Research Institute for Emergency, St. Petersburg

M V Dubina

Center of Nanotechnology, Academical University Russian Academy of Science, St. Petersburg

O N Reznik

I.I. Djanelidze State Research Institute for Emergency, St. Petersburg

Email: onreznik@yahoo.com

A V Lopota

Central Research Institute of Robotics and Technical Cybernetics, St. Petersburg

A E Skvortsov

I.I. Djanelidze State Research Institute for Emergency, St. Petersburg

A O Reznik

I.I. Djanelidze State Research Institute for Emergency, St. Petersburg

References

  1. Абрамов В.Ю. Иммунология в клинической трансплантации органов / Под ред. В.И. Шумакова // Трансплантология: Руководство для врачей. М., 2006.
  2. Bagnenko S.F., Moysyuk Y.G., Reznik O.N. et al. Machine perfusion as a tool to select kidneys recovered from uncontrolled donors after cardiac death // Transplant. Proc.2008. Vol. 40. № 4. P. 1023-1026.
  3. Биленко M.B. Ишемические и реперфузионные повреждения органов. М.: Медицина, 1989. С. 386.
  4. Брюхоненко С.С. Искусственное кровообращение целого организма (собаки) с выключенным сердцем // Труды Научного химико-фармацевтического института. 1928. Т. 20. С. 44-72.
  5. Брюхоненко С.С., Чечулин С.И. Опыты по изолированию головы собаки. 1928. С. 23.
  6. Готье С.В., Мойсюк Я.Г., Ибрагимова О.С. Органное донорство и трансплантация в российской федерации в 2009 году. Сообщение регистра российского трансплантологического общества // Вестник трансплантологии и органного донорства. 2010. Т. 12. №3. С. 6-15.
  7. Гринев K.M. Практика заготовки донорских органов по критериям смерти мозга. Преимущества без недостатков // Материалы конференции. Клиническая трансплантация органов (актуальные вопросы). М., 2005. С. 47-49.
  8. Жеребцов Ф.К., Гринев K.M. Перспективы деятельности донорской службы в Ленинградской области (по материалам 1996-2000 гг.) // Вестник трансплантологии и искусственных органов. 2002. № 1. С. 3-7.
  9. Иванов К.П., Мельникова H.H. Роль лейкоцитов в динамике микроциркуляции в норме и при патологии // Журнал общей биологии. 2004. Т. 62. № 3. С. 3-13.
  10. Нестеренко И.В. Аллотрансплантация трупных почек, полученных от маргинальных доноров: автореф. дне.. д-ра мед. наук / МОНИКИ нм. М.Ф. Владимирского и МГЦ трансплантации почки ГКБ №7. М., 2008. С. 44.
  11. Онищенко H.A. Консервация органов и тканей / Под ред. акад. В.И. Шумакова // Трансплантология: Руководство. М.: Медицина, 1995. С. 75-91.
  12. Суслов Д.Н. Прогнозирование и профилактика недостаточной функции почечного аллотрансплантата от асистоличсского донора в раннем послеоперационном периоде: автореф. дис.. канд. мед. наук. СПб.,1999. С. 23.
  13. Тарабарко Н.В. Обеспечение донорскими органами клинической трансплантации: автореф. дис.. д-ра мед. наук / НИИТ и ИО. М., 1997. С. 34.
  14. Шаршаткин A.B. Применение блокатора кальциевых каналов исрадипина для профилактики реперфузионных повреждений почечного трансплантата: автореф. дис.. канд. мед. наук / НИИТ и ИО. М., 1998.С. 22.
  15. Трансплантология: Руководство / Под ред. Шумакова В.И. М.: Медицина - Тула РЕППРОНИКС Лтд., 1995. С. 391.
  16. Adams D.H., Nash G.В. Disturbance of leucocyte circulation and adhesion to the endothelium as factors in circulatory pathology // Br. J. Anaesth. 1996. Vol. 77. P. 17-31.
  17. Ali A.A., White P., Xiang B., Lin H.Y. et al. Hearts from DCD donors display acceptable biventricular function after heart transplantation in pigs // Am. J. Transplant. 2011. Vol. 11. №8. P. 1621-1632.
  18. Allen B., llbawi M. Hypoxia, reoxygenation and the role of systemic leukodepletion in pediatric heart surgery // Perfusion. 2001. Vol. 16. P. 19-29.
  19. Álvarez-Vijande R., Luque Gálvez P. Study of cell energy charge in experimental kidney transplant with different warm ischemia periods (0,30,45, and 90’) //Actas. Urol. Esp. 2008. Vol. 32. № 1. P. 41-58.
  20. Beizer F.O., May R., Berry M.N. et al. Short term preservation of porcine livers // J. Surg. Res. 1970. Vol. 10. №2. P. 55-61.
  21. Boros P., Bromberg J.S. New Cellular and Molecular Immune Pathways in Ischemia/Reperfusion Injury // Am. J. Transplant. 2006. Vol. 6. P. 652-658.
  22. Brasile L., Stubenitskya B. M., Boostera M. H. et. al. Hypothermia - a Limiting Factor in Using Warm Ischemically Damaged Kidneys//Am. J. Transplant. 2001. Vol. 1. P. 316-320.
  23. Brasile L., Stubenitsky B.M., Haisch C.E. et al. Repair of damaged organs in vitro //Am. J. Transplant. 2005. Vol. 5. P. 300-306.
  24. Brettschneider L., Bell P.R.F., Taylor P.D et al. Conservation of the liver //Transplant. Proc. 1969. Vol. 1. № 1. P. 132-137.
  25. Brolese A., Bassanello M., Cillo U. Extreme marginal donor: severe hypothermia as a rare preservation condition for explantable organs - a case report // Transplant. Proc. 2003. Vol. 35. № 4. P. 1282-1284.
  26. Bumgardner G.L., Henry M.L. et. al. Pulsatile perfusion: a preservation strategy to optimize the use and function of transplanted kidneys // Curr. Opinion in Organ Transplant. 2007. Vol. 12. P. 345-350.
  27. Caldwell C.C., Tschoep J., Lentsch A.B. Lymphocyte function during hepatic ischemia/reperfusion injury // J. of Leukocyte Biol. 2007. Vol. 82. P. 457-464.
  28. Chang G.J., Mahanty H.D., Ascher N.L. et al. Expanding the donor pool: can the Spanish model work in the United States? //Am. J. Transplant. 2003. Vol. 3. № 10. P. 1259-1263.
  29. Cobert M.L., West L.M., Jessen M.E. Machine perfusion for cardiac allograft preservation // Curr. Opinion in Organ Transplant. 2008. Vol. 13. P. 526-530.
  30. Collins M.J., Moainie S.L., Griffith B.P. et al. Preserving and evaluating hearts with ex vivo machine perfusion: an avenue toimprove early graft performance and expand the donor pool // Eur. J. Cardiothorac. Surg. 2008. Vol. 34. P. 318-325.
  31. Collins T. Adhesion molecules in leukocyte emigration // Science and Medicine. 1995. Vol. 6. № 2. P. 28- 7.
  32. Cypel M., Yeung J.C. Technique for Prolonged Normothermic Ех-vivo Lung Evalution of nonacceptable donor lungs // Ann. Thorac. Surg. 2006. Vol. 81. P. 460-466.
  33. Cypel M., Rubachal S. Ex-Vivo Repair and Regeneration of damaged human donor lungs // J. Heart lung Trans. 2008. Vol. 27. № 2. P. 180.
  34. de Vries A.J., Gu Y.J., Post W.J. et al. Leucocyte depletion during cardiac surgery: a comparison of different filtration strategies// Perfusion. 2003. Vol. 18. P. 31.
  35. Delmonico F.L., Harmon W.E. Use of expanded criteria donors in solid organ transplantation // Curr. Opinion in Organ Transplant. 2000. Vol. 5. № 3. P. 227-231.
  36. Demetris A.J., Fontes P., Lunz J.G. et al. Wound healing in the biliary tree of liver allografts // Cell Transplant. 2006. Vol. 15. № 1. P. 57-65.
  37. Dutkowski P., de Rougemont О., Clavien P.A. Machine Perfusion for «Marginal» Liver Grafts // Am. J. Transplant. 2008. Vol. 8. P. 917-924.
  38. Fondevila C., Hessheimer A.J., Ruiz A. et al. Liver transplant using donors after unexpected cardiac death: novel preservation protocol and acceptance criteria // Am. J. Transplant. 2007. Vol. 7. P. 1849-1855.
  39. Garcia C.E., Bramhall S., Mirza D.F. Use of marginal donors // Curr. Opinion in Organ Transplant. 2000. Vol. 5. P. 50-56.
  40. Granger D.N., Kubes P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion // J. Leukocyte'Biol. 1994. Vol. 55. P. 662-675.
  41. Greenstein S.M., Schwartz G., Schechner R. et al. Selective use of expanded criteria donors for renal transplantation with good results // Transplant. Proc. 2006. Vol. 38. № 10. P. 3390-3392.
  42. Guarrera J.V., Estevez J., Boykin J. et al. Hypothermic machine perfusion of liver grafts for transplantation: technical development in human discard and miniature swine models // Transplant. Proc. 2005. Vol. 37. № 1. P. 323-325.
  43. Guarrera J.V., Karim N.A. Liver presrervation: is there anything new yet? // Curr. Opinion in Organ Transplant. 2008. Vol. 13. P. 148-154.
  44. Guarrera J.V., Henry S.D., Samstein B. et al. Hypothermic machine preservation in human liver transplantation: The first clinical series //Am. J. Transplant. 2010. Vol. 10. P. 372-381.
  45. Harper S.J., Hosgood S.A., Waller H.L. et al. The effect of warm ischemic time on renal function and injury in the isolated hemoperfused kidney // Transplant. 2008. Vol. 86. P. 445-451.
  46. Harper S., Hosgood S., Kay M. et al. Leucocyte depletion improves renal fonction during reperfusion using an experimental isolated haemoperfused organ preservation system // Br. J. Surg. 2006. Vol. 93. P. 623-629.
  47. Hassanein W.H., Zellos L., Tyrell T.A. et al. Continuous perfusion of donor hearts in the beating state extends preservation time and improves recovery of function // J. Thorac. Cardiovasc. Surg. 1998. Vol. 116. P. 821-830.
  48. Hirota M., Ishino K., Fukumasu I. et al. Prediction of functional recovery' of 60-minute warm ischemic hearts from asphyxiated canine non-heart-beating donors // J. Heart. Lung. Transplant. 2006. Vol. 25. P. 339-344.
  49. Hosgood S.A., Nicholson M.L. First in man renal transplantation after ex vivo normothermic perfusion // Transplantation. 2011. Aug 11. [Epub ahead of print]
  50. Howard R.J., Schold J.D., Cornell D.L. A 10-year analysis of organ donation after cardiac death in the United States //Transplantation. 2005. Vol. 80. № 5. P. 564-568.
  51. http://bse.sci-lib.com/articlel 20442.html
  52. http://www.transmedics.com/wt/page/la_times_ucla_ 2011-08-29
  53. Huang Y., Rabb H., Karl L. Womer Ischemia-reperfusion and immediate T cell responses // Cell. Immunol. 2007. Vol. 248. № 1. P. 4-11.
  54. Jaeschke H. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions // Am. J. Physiol. Gastrointest. Liver Physiol. 2006. Vol. 290. P. 1083- 1088.
  55. Jamieson R.W., Friend P.J. Normothennic organ preservation // Transplant. Rev. 2006. Vol. 20. P. 172-178.
  56. Jamieson R.W., Friend P.J. Organ reperfusion and preservation // Frontiers in Bioscience. 2008. Vol. 13. P. 221-235.
  57. Jassern W., Roake J. The molecular and cellular basis of reperfusion injury following organ transplantation // Transplant. Rev. 1998. Vol. 12. № 1. P. 14-33.
  58. Jensen M.C.; Karen Christensen (Interviewer) (January 14). “Integrity: Without it Nothing Works”. Rotman Magazine: The Magazine of the Rotman School of Management, pp. 16-20, Fall 2009 (Social Science Research Network), http://papers.ssm.com/sol3/papers. cfm?abstract_id= 1511274
  59. Jordan J.E., Zhi-Qing Zhao, Vinten-Johansen J. The role of neutrophils in myocardial ischemia-reperfusion injury // Cardiovasc. Res. 1999. Vol. 43. P. 860-878.
  60. Knight A.J., Nicholson M.L. Methods of renal preservation // Transplant. Rev. 2001. Vol. 15. № 2. P. 68-81.
  61. Konstantinov I.E., Alexi-Meskishvili V.V., Sergei S. Brukhonenko: the development of the first heart-lung machine for total body perfusion // Ann. Thorac. Surg. 2000. Vol. 69. P. 962-966.
  62. Koo D.H., Fuggle S.V. Impact of ischemia/reperfusion injury and early inflammatory responses in kidney transplantation // Transplant. Rev. 2000. Vol. 14. №2. P. 210-224.
  63. Koo D.D.H., Fuggle S.V. The role of mitochondria in ischemia/reperfusion injury' // Transplantation. 2002. Vol. 27. № 4. P. 493-499.
  64. Kootstra G. Asystolic or non-heartbeating donor // Transplantation. 1997. Vol. 63. № 7. P. 917-921.
  65. Land W.G. The Role of Postischemic Reperfusion Injury and Other Nonantigen-Dependent Inflammatory Pathways in transplantation //Transplantation. 2005. Vol. 79. №5. P. 505-514.
  66. Laskowski I.A., Hancock W.W., Pratchke J. et al. Accelerated graft dysfunction in renal isografts from nonheart-beating donors // Transplant. Proc. 2001. Vol. 33. P. 909-910.
  67. Lee C.M., Scandling J.D., Pavlakis M. et al. A review of the kidney that nobody wanted // Transplantation. 1998. Vol. 65. №2. P. 213-219.
  68. Linden P.K. History of solid organ transplantation and organ donation // Crit. Care Clin. 2009. Vol. 25. № 1. P. 165-184.
  69. Linfert D., Chowdhry T., Rabb H. et al. Lymphocytes and ischemia-reperfusion injury // Transplant. Rev. 2009. Vol. 23. № 1. P. 1-10.
  70. Maathuis M.H.J., Manekeller S., van der Plaats A. et al. Improved kidney graft function after preservation using a novel hypothermic device: the groningen machine perfusion system //Ann. Surg. 2007. Vol. 246. P. 982-991.
  71. Magliocca J.F., Magee J.C., Rowe S.A. et al. Extracorporeal support for organ donation after cardiac death effectively expands the donor pool // Trauma. 2005. Vol. 58. P. 1095-1102.
  72. Maximilian M.R., Polyak M.Ph., Ben OMar Arrington B.S. et al. Prostaglandin E1 influences pulsatile preservation characteristics and early graft function in expanded criteria donor kidneys // J. Surg. Res. 1999. Vol. 85. № 1. P. 17-25.
  73. McLaren J.A., Friend P.J. Trends in organ preservation //Transplant. Int. 2003. Vol. 16. P. 701-708.
  74. Menger M.D. Microcirculatory disturbances secondary to ischemia-reperfusion // Transplant. Proc. 1995. Vol. 27. № 5. P. 2863-2865.
  75. Metcalfe M.S., Waller J.R., Hosgood S.A. et al. A paired study comparing the efficacy of renal preservation by normothermic autologous blood perfusion and hypothermic pulsatile perfusion // Transplant. Proc. 2002. Vol. 34. P. 1473-1474.
  76. Moers C., Leuvenink H.G.D., Ploeg R.J. et al. Nonheart-beating organ donation: overview and future perspectives // Eur. Society for Organ Transplant. 2007. Vol. 20. P. 567-575.
  77. Moers C., Smits J.M., Maathuis M.H. et al. Machine perfusion or cold storage in deceased-donor kidney transplantation // N. Engl. J. Med. 2009. Vol. 360. P. 7-19.
  78. Mone T.D. The business of organ procurement // Curr. Opinion in Organ Transplant. 2002. Vol. 7. P. 60-64.
  79. Moustafellos P., Hadjianastassiou V., Roy D. et. al. The influence of pulsatile preservation in kidney transplantation from non-heart-beating donors //Transplant. Procs. 2007. Vol. 39. P. 1323-1325.
  80. Nicholson M.L., Simon J.F., Harper L.W. et al. The effect of warm ischemic time on renal functionand injury in the isolated hemoperfused kidney // Transplantation. 2008. Vol. 86. № 3. P. 445-451.
  81. Pierre A.F., Sekine Y., Hutcheon M.A. et al. Marginal donor lungs: a reassessment // J. Thorac. CardioVasc. Surg. 2002. Vol. 123. № 3. P. 421-428.
  82. Probert W.R., Melrouse D.G. An Early Russian Heart-Lung Machine//BMJ. 1960. Vol. 12. P. 104.
  83. Rega F.R., Neyrinnck A.P. How long can we preserve the pulmonary graft inside the NHBD? // Presented at the thirty-ninth annual meeting of the Society of surgeons (San Diego, CA). Jan 31-Feb2, 2003.
  84. Rega F.R., Vandezande E.J. The role of leukocyte depletion in ex vivo evalution of pulmonary grafts from (non-) HBD // Perfusion. 2003. Vol. 18. № 1. P. 13-21.
  85. Rega F.R., Jannis N.C., Verleden G.M. et al. Longterm Preservation with interim evalution of lungs from a NHBD after ischemic interval of 90 min // Ann. of Surgery. 2003. Vol. 238. P. 782-793.
  86. Rodriguez-Martinez D., Cabello-Benaventc R., Pedemonte G. et. al. Technical aspects of isolated organ perfusion systems // Actas. Urol. Esp. 2008. Vol. 32. № 1. P. 59-66.
  87. Rowinski W. Future of transplantation medicine // Ann. Transplant. 2007. Vol. 12. № 1. P. 5-10.
  88. Rozenthal R. Organ Donation: Quo vadis? // Ann. of Transplant. 2006. Vol. П № 3. P. 49-51.
  89. Saad S., Minor T. Short-Term resuscitation of predamaged donor livers by brief machine perfusion: the influence of temperature // Transplant. Proc. 2008. Vol. 40. P. 3321-3326.
  90. Samaniego M. Alloantibodies // Transplant immunology for the clinicians. In: Pre-meeting symposia / Am. Transplant. Congress. 2007. P. 24-33.
  91. Samankatiwat P., Samartzis I., Lertsithichai P. et al. Leucocyte depletion in cardiopulmonary bypass: a comparison of four strategies // Perfusion. 2003. Vol. 18. P. 95-105.
  92. Sanchez-Fructuoso A.I., Prats D. et al. Non-heart beating donors: experience from the Hospital Clinico of Madrid // J. Nephrol. 2003. Vol. 16. № 3. P. 387-392.
  93. Sanchez-Fructuoso A.I., Prats D., Marques M. et al. Does donor brain death influence acute vascular rejection in the kidney transplant? //Transplantation. 2004. Vol. 78. № 1. P. 142-146.
  94. Schreinemachers M.J.M. et al. Machine perfusion preservation of the liver: a worthwhile clinical activity? // Curr. Opinion in Organ Transplant. 2007. Vol. 12. 224-230.
  95. Shoskes D. Warming to non-heart-beating donors? // Am. J. Transplant. 2001. Vol. 1. P. 305-306.
  96. Slapak M., Wigmore R.A., MacLean L.D. Twenty-four hour liver preservation by the use of continuous pulsatile perfusion and hyperbaric oxygen // Transplantation. 1967. Vol. 5. №4. P. 1154-1158.
  97. Steen S., Ingemansson R., Eriksson L. et al. First Human Transplantation of Nonacceptable donor lung after reconditioning ex vivo //Ann. of Thoracic Surg. 2007. Vol. 83. №6. P. 2191-2195.
  98. Stratta R.J., Rohr M.S., Sundberg A.K. et al. Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant // Ann. Surg. 2004. Vol. 239. № 5. P. 688-697.
  99. Stubenitsky B.M., Booster M.H., Nidersting A.P. Kidney preservation in the next millenium // Transplant. Int. 1999. Vol. 12. P. 83-91.
  100. Tilney N.L., Paz D., Ames J. et al. Ischemia - reperfusion injury // Transplant. Proc. 2001. Vol. 33. P. 843-844.
  101. Tolboom H., Milwid J.M., Izamis M.L. et al. Sequential cold storage and normothermic perfusion of the ischemic rat liver // Transplant. Proc. 2008. Vol. 40. №5. P. 1306-1309.
  102. United Network for Organ Sharing Available at http:// www.UNOS.org. 2011. Accessed August 15,2011.
  103. Van der Hoeven J.A.B., Ploeg R.J. Effects of brain death on donor organ viability // Curr. Opinion in Organ Transplant. 2001. Vol. 6. P. 75-82.
  104. Van der Vliet J.A., Rievit J.K., Непе R.J. et al. Preservation of non-heat-beating donor kidneys: a clinical prospective randomized case-control study of machine perfusion versus cold storage // Transplant. Proc. 2001. Vol. 33. P. 847.
  105. Van Gelder F., Manyalich M., Nanni Costa A. et al. 2009 International donation and transplantation activity // 1RODAT. Organ, Tissues & Cells // J. Eur. Transplant. Coordinators Organization. 2010. Vol. 13. № 2. P. 77-80.
  106. Veatch R.M. Donating Hearts after Cardiac Death - Reversing the Irreversible // N. Engl. J. Med. 2008. Vol. 359. № 7. P. 672-673
  107. Wesley A.J. Pulsatile perfusion versus static storage for kidney preservation // Curr. Opinion in Organ Transplant. 2000. Vol. 5. № 3. P. 237-241.
  108. Wolfe R.A., LaPorte F.B., Rodgers A.M. et al. Developing organ offer and acceptance measures: when ‘good’ organs are turned down // Am. J. Transplant. 2007. Vol. 7. № 2. P. 1404-1411
  109. Yang B., Hosgood S.A., Harper S.J.F. et al. Leucocyte depletion improves renal function in porcine kidney hemoreperfusion through reduction of My-eloperoxidase+ Cells, Caspase-3, IL-lß, and Tubular Apoptosis // J. Surg. Res. 2010. Vol. 164. № 2. P. 315-324.
  110. Yates P.J., Hosgood S.A., Nicholson M.L. Leukocyte and platelet depletion improves blood flow and function in a renal transplant model // J. Surg. Res. 2010. doi: 10.1016/j.jss.2010.08.007

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Bagnenko S.F., Dubina M.V., Reznik O.N., Lopota A.V., Skvortsov A.E., Reznik A.O.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies