The neurochemical effects of prenatal exposure of cholinergic drugs on the brain postnatal monoaminergic system development



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Abstract

Prenatal exposure of M-and N-cholinolytics to pregnant females to produce the long-term neurochemical changes in development of brain neuromediatory systems. In the investigated of brain structures, both at males, and at females of rats progenies, exposure to prenatal cholinolytics, significant decrease of DA, 5-HT, NA concentrations and change of level of their metabolites is marked. Prenatal exposure to N-cholinolytics of gangleron to pregnant females on 9-19 gestational days exerts most appreciable long-term effect on neurotransmitter development, which leads to reduction of dopaminergic, noradrenergic and serotonergic activity in the hippocampus and hypothalamus at 2-month's rats progenies in comparison with control progeny. Is marked sexual dimorphism in the long-term effects of prenatal exposition of cholinolytics on ДА concentration in the brain structures at 2-month's rats progenies.These results indicate, that exposure to M- and N-cholinolytics during the critical periods of prenatal development (9-11 and 12-14 gestational days) result in long-term changes in development of neuromediatory systems in the brain structure, which participate in regulation of behavioral and neuroendocrinal functions at rats'offspring.

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