Regulation of gene transcription in group A and В streptococci



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Present review describes gene transcriptional regulation in group A and В pathogenic streptococci. The functions, features, mechanisms of action of two-component regulatory systems and global transcriptional regulators, as well as their influence on metabolism and virulence of streptococci are shown. The data obtained by the researchers of Department of Molecular Microbiology, Institute of Experimental Medicine, are summarized.

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A V Dmitriev

Email: admitriev10@yandex.ru

References

  1. Дмитриев A.B., Рождественская A.C., Зуткис A.A., Тотолян A.A. Направленная регуляция патогенных свойств стрептококков // Мед. акад. журн. 2009. Т. 9. № 4. С. 50-58.
  2. Дмитриев A.B., Рождественская A.C., Тотолян A.A. Использование микрочипов для изучения метаболизма и механизмов патогенности Streptococcus pyogenes // Сборник материалов XIX (82) сессии Общего собрания Российской академии медицинских наук. 2008. С. 250-266.
  3. Рождественская A.C., Дмитриев A.B., Грабовская К.Б., Тотолян A.A. Инактивация гена регулятора транскрипции Rgg изменяет экспрессию секретируемых факторов патогенности и вирулентность Streptococcus pyogenes // Мед. акад. журн. 2008. 8. №2. С. 21-27.
  4. Филатов H.H., Брико Н.И., Шаханина И.Л. и др. Научно-организационные и методические основы эпидемиологического надзора за стрептококковой инфекцией группы А в условиях крупного города //Журн. Микробиол. 1998. Т. 1. С. 40-43.
  5. Balleza E., López-Bojorquez L.N., Martinez-Antonio A. et al. Regulation by transcription factors in bacteria: beyond description // FEMS Microbiol. Rev. 2009. Vol. 33. № 1. P. 133-151.
  6. Beckert S., Kreikemeyer B., Podbielski A. Group A streptococcal rofA gene is involved in the control of several virulence genes and eukaryotic cell attachment and internalization // Infect. Immunol. 2001. Vol. 69. № 1. P. 534-537.
  7. Beres S.B., Richter E.W., Nagiec M.J. et al. Molecular genetic anatomy of interand intraserotype variation in the human bacterial pathogen group A Streptococcus // Proc. Natl. Acad. Sei. USA. 2006. Vol. 103. № 18. P. 7059-7064.
  8. Carapetis J.R., Steer A.C., Mulholland E.K., Weber M. The global burden of group A streptococcal diseases // Lancet Infect. Dis. 2005. Vol. 5. № 11. P. 685-694.
  9. Chaussee M.S., Ajdic D., Ferretti J.J. The rgg gene of Streptococcus pyogenes positively influences extra-cellular SPE В production // Infect. Immunol. 1999. Vol. 67. №4. P. 1715-1722.
  10. Chaussee M.A., Callegari E.A., Chaussee M.S. Rgg regulates growth phase-dependent expression of proteins associated with secondary metabolism and stress in Streptococcus pyogenes // J. Bacteriol. 2004. Vol. 186. №21. P. 7091-7099.
  11. Chaussee M.S., Somerville G.A., Reitzer L. et al. Rgg coordinates virulence factor synthesis and metabolism in Streptococcus pyogenes // J. Bacteriol. 2003. Vol. 185. №20. P. 6016-6024.
  12. Chaussee M.S., Watson R.O., Smoot J.C., Musser J.M. Identification of Rgg-regulated exoproteins of Streptococcus pyogenes // Infect. Immunol. 2001. Vol. 69. №2. P. 822-831.
  13. Cho K.H., Caparon M.G. Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes // Mol. Microbiol. 2005. Vol. 57. №6. P. 1545-1556.
  14. Churchward G. The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci // Mol. MÏcrobiol. 2007. Vol. 64. № I. P. 34-41.
  15. Cunningham M.W. Pathogenesis of group A streptococcal infections // Clin. Microbiol. Rev. 2000. Vol. 13. №3. P. 470-511.
  16. Dalton T.L., Hobb R.I., Scott J.R. Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease // Microbiol. Pathog. 2006. Vol. 40. № 5. P. 221-227.
  17. Dalton T.L., Scott J.R. CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes // J. Bacteriol. 2004. Vol. 186. № 12. P. 3928-3937.
  18. Dmitriev A.V., McDowell E.J., Chaussee M.S. Inter-and intraserotypic variation in the Streptococcus pyogenes Rgg regulon // FEMS Microbiol. Lett. 2008. Vol. 284. № 1. P. 43-51.
  19. Dmitriev A.V., McDowell E.J., Kappeler K.V. et al. The Rgg regulator of Streptococcus pyogenes influences the utilization of nonglucose carbohydrates, prophage induction, and expression of the NAD-glycohydrolase virulence operon // J. Bacteriol. 2006. Vol. 188. №20. P. 7230-7241.
  20. Dmitriev A., Hu Y.Y., Shen A.D. et al. Chromosomal analysis of group В streptococcal clinical strains; bac gene positive strains are genetically homogenous // FEMS Microbiol. Lett. 2002. Vol. 208. № 1. P. 93-98.
  21. Dmitriev A., Yang Y.N., Shen A.D., Totolian A.A. Adjacent location of bac gene and two-component regulatory system genes within the putative Streptococcus agalactiae pathogenicity island // Folia Microbiol. 2006. Vol. 51. № 3. P. 229-235.
  22. Engleberg N.C., Heath A., Miller A. et al. Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue in fection // J. Infect. Dis. 2001. Vol. 183. № 7. P. 1043-1054.
  23. Engleberg N.C., Heath A., Vardanian K., DiRita V.J. Contribution of CsrR-regulated virulence factors to the progress and outcome of murine skin infections by Streptococcus pyogenes // Infect. Immunol. 2004. Vol. 72. № 2. P. 623-628.
  24. Federle M.J., Mclver K.S., Scott J.R. A response regulator that represses transcription of several virulence opérons in the group A streptococcus // J. Bacteriol. 1999. Vol. 181. № 12. P. 3649-3657.
  25. Ferretti J.J., McShan W.M., Ajdic D. et al. Complete genome sequence of an Ml strain of Streptococcus pyogenes // Proc. Natl. Acad. Sci. USA. 2001. Vol. 98. № 8. P. 4658-4663.
  26. Fogg G.C., Gibson C.M., Caparon M.G. The identification of rofA, a positive-acting regulatory component of prtF expression: use of an m-γδbased shuttle mutagenesis strategy in Streptococcus pyogenes // Mol. Microbiol. 1994. Vol. 11. № 4. P. 671-684.
  27. Glaser P., Rusniok C., Buchrieser C. et al. Genome sequence of Streptococcus agalactiae. a pathogen causing invasive neonatal disease // Mol. Microbiol. 2002. Vol. 45. №6. P. 1499-1513.
  28. Goulian M. Robust control in bacterial regulatory circuits // Curr. Opin. Microbiol. 2004. Vol. 7. № 2. P. 198-202.
  29. Graham M.R., Smoot L.M., Migliaccio C.A. et al. Virulence control in group A streptococcus by a two-component gene regulatory' system: global expression profiling and in vivo infection modeling // Proc. Natl. Acad. Sei. USA. 2002. Vol. 99. № 21. P. 13855-13860.
  30. Granok A.B., Parsonage D., Ross R.P., Caparon M.G. The RofA binding site in Streptococcus pyogenes is utilized in multiple transcriptional pathways // J. Bacteriol. 2000. Vol. 182. № 6. P. 1529-1540.
  31. Gutekunst H., Eikmanns B.J., Reinscheid D.J. Analysis of RogB-controlled virulence mechanisms and gene repression in Streptococcus agalactiae // Infect. Immunol. 2003. Vol. 71. № 9. P. 5056-5064.
  32. Heath A., DiRita V.J., Barg N.L., Engleberg N.C. A two-component regulatory system. CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors, hyaluronic acid capsule, streptolysin S. and pyrogenic exoto xin В H Infect. Immunol. 1999. Vol. 67. № 10. P. 5298-5305.
  33. Hollands A., Aziz R.K., Kansal R. et al. A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence // PLoS ONE. 2008. Vol. 3. № 12. e4102.
  34. Hondorp E.R., Mclver K.S. The Mga virulence regulon: infection where the grass is greener // Mol. Microbiol. 2007. Vol. 66. № 5.P. 1056-1065.
  35. Mclver K.S. Stand-alone response regulators controlling global virulence networks in Streptococcus pyogenes // Contrib. Microbiol. 2009. Vol. 16. P. 1-17.
  36. Mclver K.S., Myles R.L. Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus // Mol. Microbiol. 2002. Vol. 43. № 6. P. 1591-1602.
  37. Mclver K.S., Thurman A.S., Scott J.R. Regulation of mga transcription in the group A streptococcus: specific binding of Mga within its own promoter and evidence for a negative regulator // J. Bacteriol. 1999. Vol. 181. № 17. P. 5373-5383.
  38. Jacob F., Monod J. Genetic regulatory mechanisms in the synthesis of proteins // J. Mol. Biol. 1961. Vol. 3. P. 318-356.
  39. Jiang S.M., Cieslewicz M.J., Kasper D.L., Wessels M.R. Regulation of virulence by a two-component system in group В Streptococcus // J. Bacteriol. 2005. Vol. 187. № 3. P. 1105-1113.
  40. Jiang S.М., Ishmael N., Hotopp J.D. et al. Variation in the group В Streptococcus CsrRS regulon and effects on pathogenicity // J. Bacteriol. 2008. Vol. 190. № 6. P. 1956-1965.
  41. Rappeler K.V., Anbalagan S., Dmitriev A.V. et al. A naturally occurring Rgg variant in serotype М3 Streptococcus pyogenes does not activate speB expression due to altered specificity of DNA binding // Infect. Immunol. 2009. Vol. 77. № 12. P. 5411-5417.
  42. Kreikemeyer B., Boyle M.D., Buttaro B.A. et al. Group A streptococcal growth phase-associated virulence factor regulation by a novel operon (Fas) with homologies to two-component-type regulators requires a small RNA molecule // Mol. Microbiol. 2001. Vol. 39.№ 2. P. 392-406.
  43. Kreikemeyer B., Nakata M., Koller T. et al. The Streptococcus pyogenes serotype M49 Nra-Ra!p3 transcriptional regulatory network and its control of virulence factor expression from the novel eno ralp3 epf sagA pathogenicity region // Infect. Immunol. 2007. Vol. 75. № 12. P. 5698-5710.
  44. Kwinn L.A., Khosravi A., Aziz R.K. et al. Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin S operon in invasive M1T1 group A Streptococcus // J. Bacteriol. 2007. Vol. 189. №4. P. 1322-1329.
  45. Lamy M.C., Zouine M., Fert J. et al. CovS/CovR of group В streptococcus: a two-component global regulatory' system involved in virulence // Mol. Microbiol. 2004. Vol. 54. № 5. P. 1250-1268.
  46. Loughman J.A., Caparon M.G. A novel adaptation of aldolase regulates virulence in Streptococcus pyogenes // EMBO 2006. Vol. 25. № 22. P. 5414-5421
  47. Loughman J.A., Caparon M.G. Contribution of invariant residues to the function of Rgg family transcription regulators // J. Bacteriol. 2007. Vol. 189. № 2. P. 650-655.
  48. Lyon W.R., Gibson C.M., Caparon M.G. A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes // EMBO J. 1998. Vol. 17. №21. P. 6263-6275.
  49. Neely M.N., Lyon W.R., Runft D.L., Caparon M. Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes // J. Bacteri ol. 2003. Vol. 185. № 17. P. 5166-5174.
  50. Neuner J.M., Hamel M.B., Phillips R.S. et al. Diagnosis and management of adults with pharyngitis. A cost-effectiveness analysis //Ann. Intern. Med. 2003. Vol. 139. №2. P. 113-122.
  51. Nizet V., Rubens C.E. Pathogenic mechanisms and virulence factors of Group В streptococci // Grampositive pathogens. Fischetti V.A., Novick R.P., Ferretti J.J., Portnoy D.A., Rood J.I. (eds). Washington, D.C: American Society for Microbiology Press, 2000. P. 125-136.
  52. Podbielski A., Woischnik М., Leonard B.A., Schmidt K.H. Characterization of nra, a global negative regulator gene in group A streptococci // Mol. Microbiol. 1999. Vol. 31. №4. P. 1051-1064.
  53. Poyart C., Lamy M.C., Boumaila C. et al. Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system // J. Bacteriol. 2001. Vol. 183. № 21. P. 6324-6334.
  54. Pulliainen A.T., Hytönen J., Haataja S., Finne J. Deficiency of the Rgg regulator promotes H202 resistance. AhpCF-mediated H202 decomposition, and virulence in Streptococcus pyogenes // J. Bacteriol. 2008. Vol. 190. №9. P. 3225-3235.
  55. Rajagopal L., Clancy A., Rubens C.E. A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence // J. Biol. Chem. 2003. Vol. 278. № 16. P. 14429-14441.
  56. Rajagopal L., Vo A., Silvestroni A., Rubens C.E. Regulation of cytotoxin expression by converging eukaryotic-type and two-component signalling mechanisms in Streptococcus agalactiae // Mol. Microbiol. 2006. Vol. 62. №4. P. 941-957.
  57. Ribardo D.A., Mclver K.S. Defining the Mga regulon: comparative transcriptome analysis reveals both direct and indirect regulation by Mga in the group A streptococcus // Mol. Microbiol. 2006. Vol. 62. № 2. P. 491-508.
  58. Roberts S.A., Churchward G.G., Scott J.R. Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly // J. Bacteriol. 2007. Vol. 189. №4. P. 1459-1463.
  59. Roberts S.A., Scott J.R. RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon // Mol. Microbiol. 2007. Vol. 66. №6. P. 1506-1522.
  60. Rozhdestvenskaya A.S., Totolian A.A., Dmitriev A.V. Inactivation of DNA-binding response regulator Sakl89 abrogates β-antigen expression and affects virulence of Streptococcus agalactiae // PLoS ONE. 2010. Vol. 5. №4. el0212.
  61. Samen U.M., Eikmanns B.J., Reinscheid D.J. The transcriptional regulator RovS controls the attachment of Streptococcus agalactiae to human epithelial cells and the expression of virulence genes // Infect. Immunol. 2006. Vol. 74. № 10. P. 5625-5635.
  62. Scott J.R., Cleary P., Caparon M.G. et al. New name for the positive regulator of the M protein of group A streptococcus // Mol. Microbiol. 1995. Vol. 17. № 4. P. 799.
  63. Sitkiewicz I., Musser J.M. Expression microarray and mouse virulence analysis of four conserved two-component gene regulator)' systems in group A streptococcus // Infect. Immunol. 2006. Vol. 74. № 2. P. 1339-1351.
  64. Spellerberg B., Rozdzinski E., Martin S. et al. rgf encodes a novel two-component signal transduction system of Streptococcus agalactiae // Infect. Immunol. 2002. Vol. 70. № 5. P. 2434-2440.
  65. Standish A.J., Stroeher U.H., Paton J.C. The two-component signal transduction system RR06/HK06 regulates expression of cbpA in Streptococcus pneumoniae // Proc. Natl. Acad. Sei. USA. 2005. Vol. 102. № 21. P. 7701-7706.
  66. Stock A.M., Robinson V.L., Goudreau P.N. Two-component signal transduction // Annu. Rev. Biochem. 2000. Vol. 69. P. 183-215.
  67. Tettelin H., Masignani V., Cieslewicz M.J. et al. Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae // Proc. Natl. Acad. Sei. USA. 2002. Vol. 99. № 19. P. 12391-12396.
  68. Tettelin H., Masignani V., Cieslewicz M.J. et al. Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial pangenome // Proc. Natl. Acad. Sei. USA. 2005. Vol. 102. №39. P. 13950-13955.
  69. Vahling C.M., Mclver K.S. Identification of residues responsible for the defective virulence gene regulator Mga produced by a natural mutant of Streptococcus pyogenes // J. Bacteriol. 2005. Vol. 1 87. № 17. P. 5955-5966.
  70. Vahling C.M., Mclver K.S. Domains required for transcriptional activation show conservation in the Mga family of virulence gene regulators // J. Bacteriol. 2006. Vol. 188. № 3. P. 863-873.
  71. Voyich J.M., Sturdevant D.E., Braughton K.R. ct al. Genome-wide protective response used by group A streptococcus to evade destruction by human polymorphonuclear leukocytes // Proc. Natl. Acad. Sci. USA. 2003. Vol. 100. № 4. P. 1996-2001.

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