Регуляция транскрипции генов у стрептококков групп А и В



Цитировать

Полный текст

Аннотация

Данный обзор посвящен вопросу регуляции транскрипции генов у патогенных стрептококков групп А и В. В работе описаны механизмы действия двухкомпонентных регуляторных систем и глобальных белков-регуляторов, их функции, особенности и влияние на метаболизм и вирулентные свойства стрептококков. В работе также представлены результаты исследований сотрудников отдела молекулярной микробиологии НИИЭМ СЗО РАМН в области изучения регуляции транскрипции генов.

Полный текст

Доступ закрыт

Об авторах

Александр Валентинович Дмитриев

ГУ «Научно-исследовательский институт экспериментальной медицины СЗО РАМН»

Email: admitriev10@yandex.ru

Список литературы

  1. Дмитриев A.B., Рождественская A.C., Зуткис A.A., Тотолян A.A. Направленная регуляция патогенных свойств стрептококков // Мед. акад. журн. 2009. Т. 9. № 4. С. 50-58.
  2. Дмитриев A.B., Рождественская A.C., Тотолян A.A. Использование микрочипов для изучения метаболизма и механизмов патогенности Streptococcus pyogenes // Сборник материалов XIX (82) сессии Общего собрания Российской академии медицинских наук. 2008. С. 250-266.
  3. Рождественская A.C., Дмитриев A.B., Грабовская К.Б., Тотолян A.A. Инактивация гена регулятора транскрипции Rgg изменяет экспрессию секретируемых факторов патогенности и вирулентность Streptococcus pyogenes // Мед. акад. журн. 2008. 8. №2. С. 21-27.
  4. Филатов H.H., Брико Н.И., Шаханина И.Л. и др. Научно-организационные и методические основы эпидемиологического надзора за стрептококковой инфекцией группы А в условиях крупного города //Журн. Микробиол. 1998. Т. 1. С. 40-43.
  5. Balleza E., López-Bojorquez L.N., Martinez-Antonio A. et al. Regulation by transcription factors in bacteria: beyond description // FEMS Microbiol. Rev. 2009. Vol. 33. № 1. P. 133-151.
  6. Beckert S., Kreikemeyer B., Podbielski A. Group A streptococcal rofA gene is involved in the control of several virulence genes and eukaryotic cell attachment and internalization // Infect. Immunol. 2001. Vol. 69. № 1. P. 534-537.
  7. Beres S.B., Richter E.W., Nagiec M.J. et al. Molecular genetic anatomy of interand intraserotype variation in the human bacterial pathogen group A Streptococcus // Proc. Natl. Acad. Sei. USA. 2006. Vol. 103. № 18. P. 7059-7064.
  8. Carapetis J.R., Steer A.C., Mulholland E.K., Weber M. The global burden of group A streptococcal diseases // Lancet Infect. Dis. 2005. Vol. 5. № 11. P. 685-694.
  9. Chaussee M.S., Ajdic D., Ferretti J.J. The rgg gene of Streptococcus pyogenes positively influences extra-cellular SPE В production // Infect. Immunol. 1999. Vol. 67. №4. P. 1715-1722.
  10. Chaussee M.A., Callegari E.A., Chaussee M.S. Rgg regulates growth phase-dependent expression of proteins associated with secondary metabolism and stress in Streptococcus pyogenes // J. Bacteriol. 2004. Vol. 186. №21. P. 7091-7099.
  11. Chaussee M.S., Somerville G.A., Reitzer L. et al. Rgg coordinates virulence factor synthesis and metabolism in Streptococcus pyogenes // J. Bacteriol. 2003. Vol. 185. №20. P. 6016-6024.
  12. Chaussee M.S., Watson R.O., Smoot J.C., Musser J.M. Identification of Rgg-regulated exoproteins of Streptococcus pyogenes // Infect. Immunol. 2001. Vol. 69. №2. P. 822-831.
  13. Cho K.H., Caparon M.G. Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes // Mol. Microbiol. 2005. Vol. 57. №6. P. 1545-1556.
  14. Churchward G. The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci // Mol. MÏcrobiol. 2007. Vol. 64. № I. P. 34-41.
  15. Cunningham M.W. Pathogenesis of group A streptococcal infections // Clin. Microbiol. Rev. 2000. Vol. 13. №3. P. 470-511.
  16. Dalton T.L., Hobb R.I., Scott J.R. Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease // Microbiol. Pathog. 2006. Vol. 40. № 5. P. 221-227.
  17. Dalton T.L., Scott J.R. CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes // J. Bacteriol. 2004. Vol. 186. № 12. P. 3928-3937.
  18. Dmitriev A.V., McDowell E.J., Chaussee M.S. Inter-and intraserotypic variation in the Streptococcus pyogenes Rgg regulon // FEMS Microbiol. Lett. 2008. Vol. 284. № 1. P. 43-51.
  19. Dmitriev A.V., McDowell E.J., Kappeler K.V. et al. The Rgg regulator of Streptococcus pyogenes influences the utilization of nonglucose carbohydrates, prophage induction, and expression of the NAD-glycohydrolase virulence operon // J. Bacteriol. 2006. Vol. 188. №20. P. 7230-7241.
  20. Dmitriev A., Hu Y.Y., Shen A.D. et al. Chromosomal analysis of group В streptococcal clinical strains; bac gene positive strains are genetically homogenous // FEMS Microbiol. Lett. 2002. Vol. 208. № 1. P. 93-98.
  21. Dmitriev A., Yang Y.N., Shen A.D., Totolian A.A. Adjacent location of bac gene and two-component regulatory system genes within the putative Streptococcus agalactiae pathogenicity island // Folia Microbiol. 2006. Vol. 51. № 3. P. 229-235.
  22. Engleberg N.C., Heath A., Miller A. et al. Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue in fection // J. Infect. Dis. 2001. Vol. 183. № 7. P. 1043-1054.
  23. Engleberg N.C., Heath A., Vardanian K., DiRita V.J. Contribution of CsrR-regulated virulence factors to the progress and outcome of murine skin infections by Streptococcus pyogenes // Infect. Immunol. 2004. Vol. 72. № 2. P. 623-628.
  24. Federle M.J., Mclver K.S., Scott J.R. A response regulator that represses transcription of several virulence opérons in the group A streptococcus // J. Bacteriol. 1999. Vol. 181. № 12. P. 3649-3657.
  25. Ferretti J.J., McShan W.M., Ajdic D. et al. Complete genome sequence of an Ml strain of Streptococcus pyogenes // Proc. Natl. Acad. Sci. USA. 2001. Vol. 98. № 8. P. 4658-4663.
  26. Fogg G.C., Gibson C.M., Caparon M.G. The identification of rofA, a positive-acting regulatory component of prtF expression: use of an m-γδbased shuttle mutagenesis strategy in Streptococcus pyogenes // Mol. Microbiol. 1994. Vol. 11. № 4. P. 671-684.
  27. Glaser P., Rusniok C., Buchrieser C. et al. Genome sequence of Streptococcus agalactiae. a pathogen causing invasive neonatal disease // Mol. Microbiol. 2002. Vol. 45. №6. P. 1499-1513.
  28. Goulian M. Robust control in bacterial regulatory circuits // Curr. Opin. Microbiol. 2004. Vol. 7. № 2. P. 198-202.
  29. Graham M.R., Smoot L.M., Migliaccio C.A. et al. Virulence control in group A streptococcus by a two-component gene regulatory' system: global expression profiling and in vivo infection modeling // Proc. Natl. Acad. Sei. USA. 2002. Vol. 99. № 21. P. 13855-13860.
  30. Granok A.B., Parsonage D., Ross R.P., Caparon M.G. The RofA binding site in Streptococcus pyogenes is utilized in multiple transcriptional pathways // J. Bacteriol. 2000. Vol. 182. № 6. P. 1529-1540.
  31. Gutekunst H., Eikmanns B.J., Reinscheid D.J. Analysis of RogB-controlled virulence mechanisms and gene repression in Streptococcus agalactiae // Infect. Immunol. 2003. Vol. 71. № 9. P. 5056-5064.
  32. Heath A., DiRita V.J., Barg N.L., Engleberg N.C. A two-component regulatory system. CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors, hyaluronic acid capsule, streptolysin S. and pyrogenic exoto xin В H Infect. Immunol. 1999. Vol. 67. № 10. P. 5298-5305.
  33. Hollands A., Aziz R.K., Kansal R. et al. A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence // PLoS ONE. 2008. Vol. 3. № 12. e4102.
  34. Hondorp E.R., Mclver K.S. The Mga virulence regulon: infection where the grass is greener // Mol. Microbiol. 2007. Vol. 66. № 5.P. 1056-1065.
  35. Mclver K.S. Stand-alone response regulators controlling global virulence networks in Streptococcus pyogenes // Contrib. Microbiol. 2009. Vol. 16. P. 1-17.
  36. Mclver K.S., Myles R.L. Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus // Mol. Microbiol. 2002. Vol. 43. № 6. P. 1591-1602.
  37. Mclver K.S., Thurman A.S., Scott J.R. Regulation of mga transcription in the group A streptococcus: specific binding of Mga within its own promoter and evidence for a negative regulator // J. Bacteriol. 1999. Vol. 181. № 17. P. 5373-5383.
  38. Jacob F., Monod J. Genetic regulatory mechanisms in the synthesis of proteins // J. Mol. Biol. 1961. Vol. 3. P. 318-356.
  39. Jiang S.M., Cieslewicz M.J., Kasper D.L., Wessels M.R. Regulation of virulence by a two-component system in group В Streptococcus // J. Bacteriol. 2005. Vol. 187. № 3. P. 1105-1113.
  40. Jiang S.М., Ishmael N., Hotopp J.D. et al. Variation in the group В Streptococcus CsrRS regulon and effects on pathogenicity // J. Bacteriol. 2008. Vol. 190. № 6. P. 1956-1965.
  41. Rappeler K.V., Anbalagan S., Dmitriev A.V. et al. A naturally occurring Rgg variant in serotype М3 Streptococcus pyogenes does not activate speB expression due to altered specificity of DNA binding // Infect. Immunol. 2009. Vol. 77. № 12. P. 5411-5417.
  42. Kreikemeyer B., Boyle M.D., Buttaro B.A. et al. Group A streptococcal growth phase-associated virulence factor regulation by a novel operon (Fas) with homologies to two-component-type regulators requires a small RNA molecule // Mol. Microbiol. 2001. Vol. 39.№ 2. P. 392-406.
  43. Kreikemeyer B., Nakata M., Koller T. et al. The Streptococcus pyogenes serotype M49 Nra-Ra!p3 transcriptional regulatory network and its control of virulence factor expression from the novel eno ralp3 epf sagA pathogenicity region // Infect. Immunol. 2007. Vol. 75. № 12. P. 5698-5710.
  44. Kwinn L.A., Khosravi A., Aziz R.K. et al. Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin S operon in invasive M1T1 group A Streptococcus // J. Bacteriol. 2007. Vol. 189. №4. P. 1322-1329.
  45. Lamy M.C., Zouine M., Fert J. et al. CovS/CovR of group В streptococcus: a two-component global regulatory' system involved in virulence // Mol. Microbiol. 2004. Vol. 54. № 5. P. 1250-1268.
  46. Loughman J.A., Caparon M.G. A novel adaptation of aldolase regulates virulence in Streptococcus pyogenes // EMBO 2006. Vol. 25. № 22. P. 5414-5421
  47. Loughman J.A., Caparon M.G. Contribution of invariant residues to the function of Rgg family transcription regulators // J. Bacteriol. 2007. Vol. 189. № 2. P. 650-655.
  48. Lyon W.R., Gibson C.M., Caparon M.G. A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes // EMBO J. 1998. Vol. 17. №21. P. 6263-6275.
  49. Neely M.N., Lyon W.R., Runft D.L., Caparon M. Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes // J. Bacteri ol. 2003. Vol. 185. № 17. P. 5166-5174.
  50. Neuner J.M., Hamel M.B., Phillips R.S. et al. Diagnosis and management of adults with pharyngitis. A cost-effectiveness analysis //Ann. Intern. Med. 2003. Vol. 139. №2. P. 113-122.
  51. Nizet V., Rubens C.E. Pathogenic mechanisms and virulence factors of Group В streptococci // Grampositive pathogens. Fischetti V.A., Novick R.P., Ferretti J.J., Portnoy D.A., Rood J.I. (eds). Washington, D.C: American Society for Microbiology Press, 2000. P. 125-136.
  52. Podbielski A., Woischnik М., Leonard B.A., Schmidt K.H. Characterization of nra, a global negative regulator gene in group A streptococci // Mol. Microbiol. 1999. Vol. 31. №4. P. 1051-1064.
  53. Poyart C., Lamy M.C., Boumaila C. et al. Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system // J. Bacteriol. 2001. Vol. 183. № 21. P. 6324-6334.
  54. Pulliainen A.T., Hytönen J., Haataja S., Finne J. Deficiency of the Rgg regulator promotes H202 resistance. AhpCF-mediated H202 decomposition, and virulence in Streptococcus pyogenes // J. Bacteriol. 2008. Vol. 190. №9. P. 3225-3235.
  55. Rajagopal L., Clancy A., Rubens C.E. A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence // J. Biol. Chem. 2003. Vol. 278. № 16. P. 14429-14441.
  56. Rajagopal L., Vo A., Silvestroni A., Rubens C.E. Regulation of cytotoxin expression by converging eukaryotic-type and two-component signalling mechanisms in Streptococcus agalactiae // Mol. Microbiol. 2006. Vol. 62. №4. P. 941-957.
  57. Ribardo D.A., Mclver K.S. Defining the Mga regulon: comparative transcriptome analysis reveals both direct and indirect regulation by Mga in the group A streptococcus // Mol. Microbiol. 2006. Vol. 62. № 2. P. 491-508.
  58. Roberts S.A., Churchward G.G., Scott J.R. Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly // J. Bacteriol. 2007. Vol. 189. №4. P. 1459-1463.
  59. Roberts S.A., Scott J.R. RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon // Mol. Microbiol. 2007. Vol. 66. №6. P. 1506-1522.
  60. Rozhdestvenskaya A.S., Totolian A.A., Dmitriev A.V. Inactivation of DNA-binding response regulator Sakl89 abrogates β-antigen expression and affects virulence of Streptococcus agalactiae // PLoS ONE. 2010. Vol. 5. №4. el0212.
  61. Samen U.M., Eikmanns B.J., Reinscheid D.J. The transcriptional regulator RovS controls the attachment of Streptococcus agalactiae to human epithelial cells and the expression of virulence genes // Infect. Immunol. 2006. Vol. 74. № 10. P. 5625-5635.
  62. Scott J.R., Cleary P., Caparon M.G. et al. New name for the positive regulator of the M protein of group A streptococcus // Mol. Microbiol. 1995. Vol. 17. № 4. P. 799.
  63. Sitkiewicz I., Musser J.M. Expression microarray and mouse virulence analysis of four conserved two-component gene regulator)' systems in group A streptococcus // Infect. Immunol. 2006. Vol. 74. № 2. P. 1339-1351.
  64. Spellerberg B., Rozdzinski E., Martin S. et al. rgf encodes a novel two-component signal transduction system of Streptococcus agalactiae // Infect. Immunol. 2002. Vol. 70. № 5. P. 2434-2440.
  65. Standish A.J., Stroeher U.H., Paton J.C. The two-component signal transduction system RR06/HK06 regulates expression of cbpA in Streptococcus pneumoniae // Proc. Natl. Acad. Sei. USA. 2005. Vol. 102. № 21. P. 7701-7706.
  66. Stock A.M., Robinson V.L., Goudreau P.N. Two-component signal transduction // Annu. Rev. Biochem. 2000. Vol. 69. P. 183-215.
  67. Tettelin H., Masignani V., Cieslewicz M.J. et al. Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae // Proc. Natl. Acad. Sei. USA. 2002. Vol. 99. № 19. P. 12391-12396.
  68. Tettelin H., Masignani V., Cieslewicz M.J. et al. Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial pangenome // Proc. Natl. Acad. Sei. USA. 2005. Vol. 102. №39. P. 13950-13955.
  69. Vahling C.M., Mclver K.S. Identification of residues responsible for the defective virulence gene regulator Mga produced by a natural mutant of Streptococcus pyogenes // J. Bacteriol. 2005. Vol. 1 87. № 17. P. 5955-5966.
  70. Vahling C.M., Mclver K.S. Domains required for transcriptional activation show conservation in the Mga family of virulence gene regulators // J. Bacteriol. 2006. Vol. 188. № 3. P. 863-873.
  71. Voyich J.M., Sturdevant D.E., Braughton K.R. ct al. Genome-wide protective response used by group A streptococcus to evade destruction by human polymorphonuclear leukocytes // Proc. Natl. Acad. Sci. USA. 2003. Vol. 100. № 4. P. 1996-2001.

Дополнительные файлы

Доп. файлы
Действие
1. JATS XML

© Дмитриев А.В., 2010

Creative Commons License
Эта статья доступна по лицензии Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах