GLUTAMINE AND ITS DERIVATIVES FOR CORRECTION OF METABOLICDISORDERS IN HIV PATIENTS



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Abstract

Glutamine content is decreased in HIV patients because of its increased metabolizing by cells of the immune system. The progression of HIV infection is associated with body weight loss in patients. This loss is aggravated by opportunistic infections associated with fever, anorexia, diarrhea and malabsorption and correlates with decreased glutamine content. Glutamine deficiency facilitates the initial immunity-mediated multiplication of HIV and may lead to perpetual (chronic) activation of the immune system even after the complete suppression of HIV. Treating HIV patients with glutamine preparations results in improved cenesthesia, decreased neurotoxic phenomena, and increased motor activity.

About the authors

V M Luft

I. I. Dzhanelidze Research Institute of Emergency Care

I. I. Dzhanelidze Research Institute of Emergency Care

A V Dmitriyev

Regional Northwest Association of parenteral and enteral nutrition

Regional Northwest Association of parenteral and enteral nutrition

N V Sizova

I. P. Pavlov First State Medical University of St. Petersburg

I. P. Pavlov First State Medical University of St. Petersburg

N A Belyakov

St. Petersburg center for the prevention and control of AIDS and infectious diseases

St. Petersburg center for the prevention and control of AIDS and infectious diseases

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