ЭПИГЕНЕТИЧЕСКИЕ ИЗМЕНЕНИЯ ПРИ ПОСТТРАВМАТИЧЕСКОМ СТРЕССОВОМ РАССТРОЙСТВЕ: ВОЗМОЖНОСТИ И ОГРАНИЧЕНИЯ ЭПИГЕНЕТИЧЕСКОЙ ТЕРАПИИ
- Авторы: Сучкова И.О.1, Паткин Е.Л.1, Цикунов С.Г.2, Софронов Г.А.3,2
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Учреждения:
- ФГБНУ «Институт экспериментальной медицины»
- ФГБНУ "Институт экспериментальной медицины"
- ФГБВОУ ВО "Военно-медицинская академия имени С.М.Кирова" МО РФ
- Раздел: Аналитический обзор
- Статья опубликована: 09.07.2024
- URL: https://journals.eco-vector.com/MAJ/article/view/632018
- DOI: https://doi.org/10.17816/MAJ632018
- ID: 632018
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Аннотация
В обзоре описаны эпигенетические механизмы, которые могут обуславливать индивидуальные различия в резистентности и риске развития посттравматического стрессового расстройства. Приводятся данные о потенциальном использовании эпигенетических модификаций в качестве биомаркеров травматического стресса и факторов, отвечающих за наследование потомками негативных последствий психогенной травмы, перенесенной родителями. Обсуждаются возможности применения и ограничения эпигенетической терапии посттравматических и связанных со стрессом расстройств.
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Об авторах
Ирина Олеговна Сучкова
ФГБНУ «Институт экспериментальной медицины»
Автор, ответственный за переписку.
Email: irsuchkova@mail.ru
ORCID iD: 0000-0003-2127-0459
SPIN-код: 4155-7314
Scopus Author ID: 6602838276
ResearcherId: H-4484-2014
канд. биол. наук, старший научный сотрудник лаборатории молекулярной цитогенетики развития млекопитающих Отдела молекулярной генетики
Россия, 197022, Санкт-Петербург, ул. Акад. Павлова, д.12Евгений Львович Паткин
ФГБНУ «Институт экспериментальной медицины»
Email: elp44@mail.ru
ORCID iD: 0000-0002-6292-4167
SPIN-код: 4929-4630
Scopus Author ID: 7003713993
ResearcherId: J-7779-2013
д-р биол. наук, профессор, заведующий Лабораторией молекулярной цитогенетики развития млекопитающих Отдела молекулярной генетики
Россия, 197022, Санкт-Петербург, ул. акад. Павлова, д.12Сергей Георгиевич Цикунов
ФГБНУ "Институт экспериментальной медицины"
Email: secikunov@yandex.ru
ORCID iD: 0000-0002-7097-1940
SPIN-код: 7771-1940
Scopus Author ID: 6506948997
ResearcherId: E-6273-2014
д-р мед. наук, профессор, заведующий лабораторией психофизиологии эмоций Физиологического отдела им. И.П. Павлова
Россия, 197022, Россия, Санкт-Петербург, ул. Акад. Павлова, 12Генрих Александрович Софронов
ФГБВОУ ВО "Военно-медицинская академия имени С.М.Кирова" МО РФ; ФГБНУ "Институт экспериментальной медицины"
Email: gasofronov@mail.ru
ORCID iD: 0000-0002-8587-1328
SPIN-код: 7334-4881
Scopus Author ID: 7003953555
ResearcherId: G-4791-2015
д-р. мед. наук, профессор, академик РАН, засл. деят. науки РФ, заведующий Лабораторией лекарственной и экологической токсикологии Научно-исследовательского отдела (медико-биологических исследований) Научно-исследовательского центра; научный руководитель ФГБНУ «Институт экспериментальной медицины»
Россия, 194044, Санкт-Петербург, ул. Акад. Лебедева, 6; 197022, Санкт-Петербург, ул. Акад. павлова, 12Список литературы
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