ГУМОРАЛЬНЫЙ И КЛЕТОЧНЫЙ ИММУНИТЕТ ПРОТИВ АТЕРОСКЛЕРОЗА: ВОЗМОЖНОСТЬ СОЗДАНИЯ ВАКЦИНЫ



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Развитие атеросклероза находится под влиянием врожденного и приобретенного иммунитета. Врожденный иммунный ответ совершается макрофагами, дендритными клетками, экспрессирующими на поверхностной мембране клеток скэвенджер- и Toll-подобные рецепторы, а также естественные антитела, способные распознавать белки, липиды, нуклеиновые кислоты, углеводы. Т- и В-лимфоциты с помощью антигенных рецепторов могут также, но с большей специфичностью, участвовать в распознавании молекул, в том числе наиболее важных в атеросклерозе. Имеются наблюдения, предполагающие, что селективная супрессия проатерогенных или селективная активация антиатерогенных иммунных ответов может обеспечить новые подходы для предотвращения или лечения атеросклероза.

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Об авторах

В А НАГОРНЕВ

ГУ «Научно-исследовательский институт экспериментальной медицины РАМН»; ГНЦ «Государственный научно-исследовательский институт особо чистых биопрепаратов ФМБА России», Санкт-Петербург

Академик РАМН

С А КЕТЛИНСКИЙ

ГУ «Научно-исследовательский институт экспериментальной медицины РАМН»; ГНЦ «Государственный научно-исследовательский институт особо чистых биопрепаратов ФМБА России», Санкт-Петербург

член-корреспондент РАМН

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