ROLE AND METHODS OF ENDOTHELIAL ESTIMATION DYSFUNCTION IN THE PRACTICAL MEDICINE



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Abstract

Realization of the role of endothelium as an independent organ in the unified syste m of regulation of blood circulation and realization of endothelial dysfunction as a key component of the pathological condition that is connected w ith most factors,if not to s ay with all factors of the cardiovascular risk,has led to the w homping increase of researches of endothelium during the last three decades. Methods of estimation of the regular vascular (endothelial) function are used widely in scientific researches; but their usage as a clinical tool in the daily medical practice is still an exception. The proposed overview contains the description of the most popular methods of estimation and monitoring of the vascular function by taking into consideration the possibility of their application in the practical medicine. In particular, data about the reason are provided why the endothelial disfunction is not only a risk marker for cardiovascular pathologies, but also contains the valuable prognostic information for the secondary prevention of diseases and management of patients suffering with the ischemic heart disease, hypertension or with the lever pathology that have already been determined. For the clinical application methods of estimation of the function of the endothelium that are simple, accessible , and light for patients are the most perspective methods. However for using them in the daily clinical practice the next following goal-oriented researches in this direction are necessary. Their task is to determine it , how and in which cases it is goal-oriented,to use such estimations; how do they influence the choosing of the treatment, and which clinical effect of application of these methods at the treatment of concrete diseases is awaited.

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About the authors

A V Shabrov

Institute of Experimental Medicine

Academician of the Russian Academy of Sciences

A G Apresyan

North-Western State Medical University named after I.I. Mechnikov

A L Dobkes

North-Western State Medical University named after I.I. Mechnikov

S U Ermolov

North-Western State Medical University named after I.I. Mechnikov

T V Ermolova

North-Western State Medical University named after I.I. Mechnikov

S G Manasyan

North-Western State Medical University named after I.I. Mechnikov

S V Serdyukov

North-Western State Medical University named after I.I. Mechnikov

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