CAUSATIVE FACTORS OF HYPOPERFUSION OF CEREBRUM IN CASE OF OBLITERATING ATHEROSCLEROSIS



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Factors have been analyzed that have influence on development and progression of haemodynamic damages of the cerebral blood flow at constrictive damages of extracranial cerebral arteries (EA) having the local form, and at the associated multifocal atherosclerotic process. Causative characteristics of the development of the constrictive lesion of arteries at their localization in different vascular district have been detected. The estimation of the significance of risk factors for the progress of ischemic cerebral complications in case of the atherosclerotic constrictive lesion of extracranial arteriae has been carried out, 276 patients took part in the study. The comparability of correctable factors has been noted that have influence on the progress of the constrictive atherosclerosis of EA and the ischemic damage of the cerebrum. Arterial hypertension (54.5%), increase of the body weight (51.3%), and smoking (35.9%) had the crucial significance. The significant increase of the influence of the genetic predisposition to the atherosclerosis, i.e. the primary hyperlipoproteinemia (HLP) and smoking, occurred at patients who have suffered with acute damages of the cerebral circulation, correspondingly in 50.8% and 34.6% of cases. Results of the research of the lipid exchange testified of the domination of the 2b type of the HLP at early and late stages of the cerebral ischemia with the increase of the level of the total cholesterol (TC), atherogenic lipoproteins (LP) - LDL, low density lipoproteins as well as triglycerides (TG). The participation of products of free-radical oxidation of lipids in the progress of the cerebral ischemic damage and atherostenosis of extracranial arteria was confirmed with the increase of the level of primary products and intensification of processes of peroxidation of lipids (POL) on condition of absence of the sufficient activation of the antioxidant defense of the organism.

Full Text

Restricted Access

About the authors

N S Subbotina

Petrozavodsk State University

I P Dudanov

Petrozavodsk State University

Member of the RAS

M N Korobkov

Petrozavodsk State University

E V Kozlovskaia

Petrozavodsk State University

References

  1. Скворцова В.И. Медицинская и социальная значимость проблемы ишемического инсульта. Качество жизни // Медицина. 2004. Т. 4, № 7. С. 2-6. [Skvortsova V.I., Medicine. 2004, vol. 4, No 7, рр. 2-6.].
  2. Кадыков А.С., Шахпаронова Н.В. Профилактика первичных и повторных ишемических инсультов: роль антиагрегантной терапии // Consilium medicum. 2014. Т. 16, № 10. С. 53-56. [Kadikov A. S., Sahparonova N. V., Consilium medicum. 2014, vol. 16, No 10, рр. 53-56.].
  3. Гинцбург А.Л., Лиходед В.Г., Бондаренко В.М. Экзогенные и эндогенные факторы в патогенезе атеросклероза. Рецепторная теория атерогенеза. // Российский кардиологический журнал. 2010. № 2. С. 92-96. [Gintsburg A. L., Likhoded V. G., Bondarenko V. M., Russian journal of cardiology, 2010, No 2, рр. 92-96.].
  4. Admani A.K., Mangion D.M., Naik D.R. Extracranial carotid artery stenosis: prevalence and associates risk factors in elderly stroke patients // Atherosclerosis. 1991. Vol. 86. P. 31-37.
  5. Aronow W.S., Ahn C., Shoenfeld M.R. Rise factors for ex-tracranial internal or common carotid arterial disease in elderly patients // Am. J. Cardiol. 1993. Vol. 71. P. 1479-1481.
  6. Парфенов В.А. Одиннадцатое Европейское совещание по артериальной гипертонии // Неврол. журн. 2001. T. 6, № 6. C 60-61. [Parfenov V.A., Neurology J., 2001, vol. 6, No 6, рр. 60-61.].
  7. Остроумова О.Д., Фомина В.М. Артериальная гипертония и риск инсульта // Consilium medicum. 2014. № 1. С. 5-6. [Ostroumova O.D., Fomin V.M., Consilium medicum, 2014. No 1, рр. 5-6.].
  8. Скворцова В.И. Стаховская Л.В. Современные подходы к профилактике инсульта. Качество жизни // Медицина. 2004. T. 4, № 7. С. 20-24. [Skvortsova V.I., Stakhovskaya L.V., Medicine, 2004, vol. 4, No 7, рр. 20-24.].
  9. Margitic S.E., Bond M.G., Crouse J.R., Furberg C.D., Probstfield J.L. Progression and regression of carotid atherosclerosis in clinical trials // Atheroscler. Thromb. 1991. Vol. 11. P. 443-451.
  10. Koren-Morag N., Tanne D., Graff E., Goldbourt U. Low- and high-density lipoprotein cholesterol and ischemic cerebrovascular disease: the bezafibrate infarction prevention registry // Arch Intern Med. 2002. Vol. 162. P. 993-999.
  11. Alva F., Samaniego V., Gonzales V., Moguel R., Meaney E. Structural and dynamic changes in elastic arteries due to arterial hypertension and hypercholestcrolemia // Clin. Cardiol. 1993. Vol. 16. P. 614-618.
  12. Shahar E., Chambless L.E., Rosamond W.D., Boland L.L., Ballantyne C.M., McGovern P.G., Sharrett A.R. Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study // Stroke. 2003. Vol. 34. P. 623-631.
  13. Novo S., Longo В., Barbarella C.M. Tantillo R., Caruso R., Longo B. Prevalence of carotid alterations in asymptomatic subjects with and without hypercholesterolemias. International Symposium on Atherosclerosis, 10th: Abstracts // Atherosclerosis. 1994. Vol. 109. P. 35.
  14. Воскобой И.В., Мазуров А.В. Повышенный уровень агрегации тромбоцитов, индуцированной активирующим антителом против гликопротеинов II b-III a, у больных острым коронарным синдромом // Кардиология. 2004. № 10. С. 64-71. [Voskoboy I. V., Mazur A. V., Cardiology, 2004, No 10, рр. 64-71.]
  15. Ford E., Li C., Pearson W., Zhao G., Mokdad A. Trends in hypercholesterolemia, treatment and control among United States adult // Int. J. Cardiol. 2010. Vol. 140. P. 226-235.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Subbotina N.S., Dudanov I.P., Korobkov M.N., Kozlovskaia E.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies