CAUSATIVE FACTORS OF HYPOPERFUSION OF CEREBRUM IN CASE OF OBLITERATING ATHEROSCLEROSIS

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Abstract


Factors have been analyzed that have influence on development and progression of haemodynamic damages of the cerebral blood flow at constrictive damages of extracranial cerebral arteries (EA) having the local form, and at the associated multifocal atherosclerotic process. Causative characteristics of the development of the constrictive lesion of arteries at their localization in different vascular district have been detected. The estimation of the significance of risk factors for the progress of ischemic cerebral complications in case of the atherosclerotic constrictive lesion of extracranial arteriae has been carried out, 276 patients took part in the study. The comparability of correctable factors has been noted that have influence on the progress of the constrictive atherosclerosis of EA and the ischemic damage of the cerebrum. Arterial hypertension (54.5%), increase of the body weight (51.3%), and smoking (35.9%) had the crucial significance. The significant increase of the influence of the genetic predisposition to the atherosclerosis, i.e. the primary hyperlipoproteinemia (HLP) and smoking, occurred at patients who have suffered with acute damages of the cerebral circulation, correspondingly in 50.8% and 34.6% of cases. Results of the research of the lipid exchange testified of the domination of the 2b type of the HLP at early and late stages of the cerebral ischemia with the increase of the level of the total cholesterol (TC), atherogenic lipoproteins (LP) - LDL, low density lipoproteins as well as triglycerides (TG). The participation of products of free-radical oxidation of lipids in the progress of the cerebral ischemic damage and atherostenosis of extracranial arteria was confirmed with the increase of the level of primary products and intensification of processes of peroxidation of lipids (POL) on condition of absence of the sufficient activation of the antioxidant defense of the organism.

N S Subbotina

Petrozavodsk State University

I P Dudanov

Petrozavodsk State University

Member of the RAS

M N Korobkov

Petrozavodsk State University

E V Kozlovskaia

Petrozavodsk State University

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Copyright (c) 2017 Subbotina N.S., Dudanov I.P., Korobkov M.N., Kozlovskaia E.V.

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