MODERN CONCEPTS OF THE PATHOGENESIS, RISK FACTORS, AND APPROACHES TO THE TREATMENT OF POSTSTROKE DEPRESSION



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Abstract

The review addresses up-do-date data about the pathogenesis and pathophysiology of poststroke depressive conditions. The neurobiological and psychological hypotheses of the development of depressive states after stroke are considered. The significance of brain lesion localization and size, neuromediator disbalance, neurotrophic factor deficit, immune system activation, hypothalamus-pituitary-adrenal system hyperactivity, disturbed neurogenesis, reduced brain blood flow, and personal traits and peculiarities of responses to stress are discussed. The likely trends of the further studies of risk factors of depressive conditions after stroke and of therapy for such conditions are delineated.

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About the authors

S G Belokoskova

Institute of Experimental Medicine

Email: belokoskova.s@yandex.ru
St. Petersburg, Russia

S G Tsikunov

Institute of Experimental Medicine

Email: secikunov@yandex.ru
St. Petersburg, Russia

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