BLOOD ANTIOXIDANT STATUS AT ACUTE AND CHRONIC DISORDER OF CEREBRAL CIRCULATION

The purpose of the research - to study of the blood antioxidant status, including total antioxidant activity (TAA) of blood plasma and enzymatic antioxidant system (AOS) of red cells (activity of glutathione peroxidase, catalase, superoxide dismutase and glutathione content) in conjunction with the aggregation activity of platelets and erythrocytes in 42 patients with brain infarction (BI) and 20 patients with discirculatory encephalopathy (DEP). It was found that on the 10 th day of treatment of cerebral ischemia blood antioxidant status had the distinction depending on the etiopathogenesis of the pathological process. At DEP it has been revealed the recovering activity of AOS. At acute BI it was revealed pronounced imbalance between antioxidants and prooxidants of blood and TAA decreasing was associated with the severity of ischemic stroke in patients at discharge from hospital. For the first time it was identified a strong inverse relationship between platelet aggregation and the severity of blood TAA deficit, as well as between erythrocytes aggregation and the activity of SOD, catalase of erythrocyte membranes in patients with BI against the background of ongoing antithrombotic therapy.

cerebral infarction, encephalopathy, antioxidant system of blood, red cells, platelets