CHOLINERGIC STRUCTURES OF THE CINGULATE CORTEX OF THE RAT BRAIN



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Abstract

Cingulate cortex of the brain is involved in various regulatory processes of the central nervous system and its defects are observed in some psychopathologic states. The present study is aimed to description of distribution and morphologic characterization of cholinergic structures of the cingulate cortex of the brain by revealing of choline acetyltransferase (ChAT) using immunohistochemistry and confocal laser microscopy. A lot of ChAT-immunoreactive fibers and some ChAT-immunoreactive neurons are found in the cingulate cortex. Small and mostly spindle-like neurons were observed predominantly in II-III layers. Fibers have many varicosities, but we failed to find any ChAT-immunopositive terminals, which supports the non-synaptic release of acetylcholine from varicosities. In the area of the cingulum with highly extensive ChAT-immunostaining, some small, mostly unipolar ChAT-immunopositive neurons were found, which have not previously been described.

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About the authors

D E Korzhevskii

Institute of Experimental Medicine of the North West Branch of the Russian Academy of Medical Science

Email: DEK2@yandex.ru

I P Grigorev

Institute of Experimental Medicine of the North West Branch of the Russian Academy of Medical Science

A D Novikova

Institute of Experimental Medicine of the North West Branch of the Russian Academy of Medical Science

V A Kovalchuk

Institute of Experimental Medicine of the North West Branch of the Russian Academy of Medical Science

O V Kirik

Institute of Experimental Medicine of the North West Branch of the Russian Academy of Medical Science

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Copyright (c) 2013 Korzhevskii D.E., Grigorev I.P., Novikova A.D., Kovalchuk V.A., Kirik O.V.

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