BISPECIFIC PROTEIN KINASE PHOSPHATASE DUSP9 AS A NEW BIOMARKER FOR CLEAR CELL RENAL CELL CARCINOMA AND PROSPECTS FOR ITS UTILISING FOR GENE THERAPY



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Abstract

The most common histological type of RCC is clear cell carcinoma. Although in 70% of the cases renal cancer is diagnosed at the localized stage, metastases develop in more than a half of the patients after surgical treatment. Resistance of RCC against chemotherapy and radiotherapy is the reason of high mortality rate of patients with metastatic renal cancer. Understanding of molecular mechanisms of tumor formation and growth would allow for the development of new diagnostic and prognostic markers, and new treatment strategies of malignant tumors. In this article we discuss the novel trends in the field of treatment of kidney malignant diseases. In particular, we address the questions of prospects and problems of gene therapy approaches for the treatment of kidney cancer. During the recent years we have investigated the DUSP9 gene. This paper summarizes our own data and the results of other investigations of the properties and functions of DUSP9 gene. We conclude that DUSP9 can be considered as a new biomarker for clear cell carcinoma, as well as the gene for kidney cancer gene therapy.

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About the authors

A M Granov

Russian Research Center of Radiology and Modern Surgical Technologies

Email: crirr@peterlink.ru
St.-Petersburg, Russia

E I Yakubovich

Russian Research Center of Radiology and Modern Surgical Technologies

St.-Petersburg, Russia

V I Evtushenko

Russian Research Center of Radiology and Modern Surgical Technologies

St.-Petersburg, Russia

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Copyright (c) 2012 Granov A.M., Yakubovich E.I., Evtushenko V.I.

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