Open Access Open Access  Restricted Access Access granted  Restricted Access Subscription or Fee Access

Vol 12, No 3 (2012)

Articles

BISPECIFIC PROTEIN KINASE PHOSPHATASE DUSP9 AS A NEW BIOMARKER FOR CLEAR CELL RENAL CELL CARCINOMA AND PROSPECTS FOR ITS UTILISING FOR GENE THERAPY

Granov A.M., Yakubovich E.I., Evtushenko V.I.

Abstract

The most common histological type of RCC is clear cell carcinoma. Although in 70% of the cases renal cancer is diagnosed at the localized stage, metastases develop in more than a half of the patients after surgical treatment. Resistance of RCC against chemotherapy and radiotherapy is the reason of high mortality rate of patients with metastatic renal cancer. Understanding of molecular mechanisms of tumor formation and growth would allow for the development of new diagnostic and prognostic markers, and new treatment strategies of malignant tumors. In this article we discuss the novel trends in the field of treatment of kidney malignant diseases. In particular, we address the questions of prospects and problems of gene therapy approaches for the treatment of kidney cancer. During the recent years we have investigated the DUSP9 gene. This paper summarizes our own data and the results of other investigations of the properties and functions of DUSP9 gene. We conclude that DUSP9 can be considered as a new biomarker for clear cell carcinoma, as well as the gene for kidney cancer gene therapy.
Medical academic journal. 2012;12(3):7-14
pages 7-14 views

ADVANCED MORPHOLOGICAL APPROACHES TO THE STUDY OF PERIPHERAL NERVE REGENERATION

Petrova E.S., Pavlova N.V., Korzhevsky D.E.

Abstract

This review is devoted to the recovery of peripheral nerves after injury. The prevalence of injuries of nerves and lack of knowledge about the mechanisms of regeneration of peripheral nerve fibers determine the actuality of the problem. Characteristics of the main methods for selective immunohistochemical detection of neuronal markers, proteins of axonal transport, markers of Schwann cells and myelin sheaths are given in the review. Methods of retrograde labeling of motoneurons and sensory neurons are also characterized. The most interesting results of recent experimental studies using these methods are given in the review. There are two basic strategies to connect the segments of nerve damage: the use of biodegradable scaffolds and conduits and the application of stem cells. Stem cells are source of the growth and trophic factors. This paper contains the necessary information about the complicated and efficient methods of molecular and cellular analysis used in studying of the mechanisms of recovery processes which develop in the nervous system after injury. The widespread use of these morphological approaches should help improve the efficiency of scientific research on the development of new medical technologies.
Medical academic journal. 2012;12(3):15-29
pages 15-29 views

ACTIVATION OF CEREBROVASCULAR PATIENTS’ SUPPRESSOR CELLS

Subbotina N.S., Oleynik Y.K., Churov A.V., Oleynik V.M., Zhulay G.A., Kravchenko P.N., Stafeeva I.V.

Abstract

The work presentsthe study of materials especially the immune system changes, including Treg lymphocytes in patients with acute and chronic cerebral ischemia. Changes in the immune status of the patients seen in reducing the total number of T-lymphocytes. It is shown that in patients with cerebrovascular diseases, changes in the functional state of cells and, in particular, in the system of Treg cells responsible for immune suppression.
Medical academic journal. 2012;12(3):30-34
pages 30-34 views
pages 35-37 views

MORFOFUNKTsIONAL'NYE OSNOVY OTKLONENII V POVEDENII NA MODELI OSTROGO VITAL'NOGO STRESSA U KRYS

Beznin G.V., Pshenichnaya A.G., Kusov A.G., Tsikunov S.G.
Medical academic journal. 2012;12(3):37-40
pages 37-40 views
pages 40-42 views

ROL' GENA SWS V FORMIROVANII NEIROMYShEChNYKh SOEDINENIY DROSOPHILA MELANOGASTER I VYPOLNENII SINAPTIChESKIKh FUNKTsIY

Kislik G.A., Trush E.I., Sarantseva S.V.
Medical academic journal. 2012;12(3):42-43
pages 42-43 views

PATOMORFOLOGIChESKIE ASPEKTY LOKAL'NOGO PRIMENENIYa EPIDERMAL'NOGO FAKTORA ROSTA PRI TERMIChESKOY TRAVME

Osikov M.V., Likhacheva A.G., Ogneva O.I.
Medical academic journal. 2012;12(3):43-45
pages 43-45 views
pages 46-48 views

DINAMIKA POKAZATELEY ENDOTOKSEMII PRI OSTROM OTRAVLENII AMITRIPTILINOM

Chekmarev G.V.
Medical academic journal. 2012;12(3):48-50
pages 48-50 views
pages 50-53 views
pages 53-55 views

SOChETANNOE PRIMENENIE IN VITRO FAKTORA NEKROZA OPUKhOLI-α (AL'NORIN) S PROTIVOOPUKhOLEVYMI PREPARATAMI NA KLETOChNYKh LINIYaKh MELANOM

Bigvava K.A., Zabotina T.N., Borunova A.A., Slavina E.G.
Medical academic journal. 2012;12(3):55-57
pages 55-57 views
pages 57-59 views
pages 59-60 views

PROTIVOVOSPALITEL'NAYa AKTIVNOST' KhITOZANA I EGO NIZKOMOLEKULYaRNOGO PROIZVODNOGO

Kalitnik A.A., Markov P.A., Volod'ko A.V.
Medical academic journal. 2012;12(3):60-61
pages 60-61 views

SRAVNITEL'NYY ANALIZ SVOYSTV POSTOYaNNYKh LINIY EMBRIONAL'NYKh STVOLOVYKh KLETOK ChELOVEKA, PRI KUL'TIVIROVANII V RAZNYKh SISTEMAKh

Kol'tsova A.M., Gordeeva O.F., Zenin V.V., Lifantseva N.V., Musorina A.S., Yakovleva T.K., Polyanskaya G.G.
Medical academic journal. 2012;12(3):61-63
pages 61-63 views

KhARAKTERISTIKA RADIATsIONNO-INDUTsIROVANNYKh IZMENENIY SUBPOPULYaTsIONNOGO SOSTAVA KUL'TURY KLETOK LINII HeLa

Lipunov N.M., Zamulaeva I.A.
Medical academic journal. 2012;12(3):63-65
pages 63-65 views

IZMENENIE ChUVSTVITEL'NOSTI BAKTERIY ESCHERICHIA COLI K DEYSTVIYu ANTIBIOTIKOV V PRISUTSTVII RASTITEL'NYKh POLIFENOLOV

Samoylova Z.Y., Smirnova G.V., Oktyabr'skiy O.N.
Medical academic journal. 2012;12(3):65-66
pages 65-66 views
pages 67-69 views

VZAIMOSVYaZI MEZhDU AKTIVNOST'Yu MONOAMINOOKSIDAZ I SVOBODNORADIKAL'NYM OKISLENIEM V MITOKhONDRIYaKh GOLOVNOGO MOZGA PRI STRESSE

Deev R.V., Sinitskiy A.I., Kozochkin D.A., Tyumentsev M.A., Galiullina I.G., Yunusova A.K., Zaripova Z.Z., Tseylikman D.V., Nikitina A.A., Gimazutdinova D.I.
Medical academic journal. 2012;12(3):70-72
pages 70-72 views
pages 72-73 views
pages 74-75 views

ROL' BELKA STAT5 V EKSPRESSII RETsEPTORA INTERLEYKINA-2 V LIMFOTsITAKh KROVI ChELOVEKA

Mityushova E.V.
Medical academic journal. 2012;12(3):75-77
pages 75-77 views

IDENTIFIKATsIYa ADDUKTOV FOSFORORGANIChESKIKh OTRAVLYaYuShchIKh VEShchESTV S BELKAMI KROVI METODAMI FOSFOPROTEOMIKI

Murashko E.A., Dubrovskiy Y.A., Podol'skaya E.P., Babakov V.N.
Medical academic journal. 2012;12(3):77-79
pages 77-79 views
pages 80-81 views
pages 81-82 views

OTsENKA IMMUNNOGO STATUSA U BOL'NYKh SOSUDISTYMI ZABOLEVANIYaMI GOLOVNOGO MOZGA

Zhulay G.A., Churov A.V., Kravchenko P.N.
Medical academic journal. 2012;12(3):83-85
pages 83-85 views

REKOMBINANTNYE POLIPEPTIDY KAK BIOMARKERY OTsENKI IMMUNOLOGIChESKOI EFFEKTIVNOSTI VAKTsINATsII ZhIVOY ChUMNOY VAKTsINOY U LYuDEY

Lyapina A.M., Fedorova V.A., Khizhnyakova M.A., Telepnev M.V., Motin V.L.
Medical academic journal. 2012;12(3):85-87
pages 85-87 views

OSOBENNOSTI POVERKhNOSTNOY EKSPRESSII AKTIVIRUYuShchIKh RETsEPTOROV VROZhDENNOGO IMMUNITETA NA SUBPOPULYaTsIYaKh MONOTsITOV

Matveeva V.G., Golovkin A.S., Chernova M.N.
Medical academic journal. 2012;12(3):87-89
pages 87-89 views

FORMIROVANIE NEITROFIL'NYKh VNEKLETOChNYKh LOVUShEK V USLOVIYaKh GIPOKINETIChESKOGO STRESSA

Plekhanova E.V., Dolgushin I.I., Tseylikman V.E., Sinitsin A.I., Markova V.A., Savochkina A.Y., Mezentseva E.A., Bondarenko T.G., Pegushina I.V., Gizinger O.A.
Medical academic journal. 2012;12(3):90-91
pages 90-91 views

VLIYaNIE TsITOKINOV NA MIGRATsIONNUYu AKTIVNOST' KLETOK TROFOBLASTA LINII Jeg-3

Stepanova O.I., Mammedova D.T., Sokolov D.I., Sel'kov S.A.
Medical academic journal. 2012;12(3):92-93
pages 92-93 views

MORFOLOGIChESKIM ANALIZ I DINAMIKA GIDROKORTIZON-INDUTsIROVANNOY ATROFII TIMUSA

Starskaya I.S., Kudryavtsev I.V., Polevshchikov A.V.
Medical academic journal. 2012;12(3):94-96
pages 94-96 views

VLIYaNIE ANTIMIKROBNOGO PEPTIDA INDOLITsIDIN NA FUNKTsIONAL'NUYu AKTIVNOST' MAKROFAGOV PRI TERMIChESKIKh OZhOGAKh KOZhI

Shevchenko N.I., Lyashev Y.D., Mishustin V.N.
Medical academic journal. 2012;12(3):96-98
pages 96-98 views

STIMULYaTsIYa TsITOTOKSIChESKOGO OTVETA V KUL'TURE MONONUKLEARNYKh KLETOK BOL'NYKh RAKOM MOLOChNOY ZhELEZY S POMOShch'Yu DENDRITNYKh KLETOK, TRANSFETsIROVANNYKh POLIEPITOPNOY DNK-KONSTRUKTsIEY

Khantakova Y.N., Kurilin V.V., Shevchenko Y.A., Lopatnikova Y.A., Sidorov S.V., Maksyutov A.Z., Maksyutov R.A., Gavrilova E.V., Zaytsev S.A., Sennikov S.V.
Medical academic journal. 2012;12(3):98-99
pages 98-99 views

REKOMBINANTNYY BELOK TEPLOVOGO ShOKA Hsp70 V IMMUNOTERAPII OPUKhOLEY GOLOVNOGO MOZGA

Shevtsov M.A., Pozdnyakov A.V., Mikhrina A.L., Meshalkina D.A., Bychkova N.V., Romanova I.V., Guzhova I.V., Khachatryan V.A., Margulis B.A.
Medical academic journal. 2012;12(3):99-101
pages 99-101 views

SERGEY FEDOROVICh BAGNENKO K 55-LETIYu SO DNYa ROZhDENIYa

- -.
Medical academic journal. 2012;12(3):102-103
pages 102-103 views

PRAVILA OFORMLENIYa STATEY

- -.
Medical academic journal. 2012;12(3):104-104
pages 104-104 views


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies