Rabbit models of ischemic stroke in biomedical research

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Abstract

The development of experimental models of ischemic stroke allowing for effective translation of results from animal studies to humans is an important task of modern neuropharmacology. Due to the fact that new drugs with neuroprotective properties that have shown activity in rodents most often turn out to be not effective enough in humans, the use of larger laboratory animals may become a viable solution. Among the latter, rabbits are the most accessible species for laboratories. Since they have gyrencephalic brains and a significant amount of white matter, they can be considered to be highly similar to humans. In the present review, we discussed the main methods of ischemic stroke modelling in rabbits. The breed, age and sex of the animals, anesthesia methods as well as criteria for functional state assessment after cerebral ischemia are the issues that should be addressed before the start of the study.

About the authors

Yuriy I. Sysoev

Saint-Petersburg Chemical-Pharmaceutical University, St. Petersburg

Author for correspondence.
Email: susoyev92@mail.ru
ORCID iD: 0000-0003-4199-5318
SPIN-code: 3359-7902

senior lecturer at the Department of Pharmacology and Clini-cal Pharmacology

Russian Federation, 197376, St. Petersburg, Professora Popova st., 14

Veronika A. Prikhodko

Saint-Petersburg Chemical-Pharmaceutical University, St. Petersburg

Email: veronika.prihodko@pharminnotech.com
ORCID iD: 0000-0002-4690-1811
SPIN-code: 4774-9096

graduate student at the Department of Pharmacology and Clinical Pharmacology

Russian Federation, 197376, St. Petersburg, Professora Popova st., 14

Dmitry Y. Ivkin

Saint-Petersburg Chemical-Pharmaceutical University, St. Petersburg

Email: dmitry.ivkin@pharminnotech.com
ORCID iD: 0000-0001-9273-6864
SPIN-code: 9981-9772

PhD of Biological Sciences , Аssociate Professor at the Depart-ment of Pharmacology and Clinical Pharmacology

Russian Federation, 197376, St. Petersburg, Professora Popova st., 14

Sergey Okovity

Saint-Petersburg Chemical-Pharmaceutical University, St. Petersburg

Email: sergey.okovity@pharminnotech.com
ORCID iD: 0000-0003-4294-5531
SPIN-code: 7922-6882

PhD in Medicine, Professor, head of the Department of Pharma-cology and Clinical Pharmacology

Russian Federation, 197376, St. Petersburg, Professora Popova st., 14

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