Prevention and treatment of cancer using so-called medicinal mushrooms raw materials: Criticism, facts, and perspectives

Abstract


The purpose of the present review is the analysis of modern knowledge on use of “medicinal mushrooms” metabolites in cancer treatment, including in vitro experiments and clinical studies, with a preliminary assessment of the prospects for the development at least of some tactics of immunotherapy for malignant neoplasms. The data on the efficacy of adjuvant therapy of tumors in combination with mushroom extracts in relation to tumor regression as well as improving overall survival rates are presented. It is postulated that the improvement of long-term results of treatment can be most successfully reached with the use of “medicinal mushrooms” raw materials. This is due to the fact that an important task after adjuvant therapy (i.e. enhancing the immune surveillance of tumor derivatives) can be successfully solved using polysaccharides of fungal origin. In their final links and targets, such a practice coincides with clinically proven cytokine therapy. The involvement of Russian clinicians in practice of assessment of long-term results of treatment with fungal dectin-stimulation seems to us to be important task of clinical oncology.


About the authors

Ivan V. Zmitrovich

Komarov Botanical Institute of the Russian Academy of Sciences, St. Petersburg, Russia

Author for correspondence.
Email: iv_zmitrovich@mail.ru
ORCID iD: 0000-0002-3927-2527

Russian Federation, 197376, St. Petersburg, Professor Popov str., 2

D.Sc. in Biology, Leading Researcher, Laboratory of Systematics and Geography of the Fungi

Vyacheslav A. Vlasenko

Central Siberian Botanical Garden SB RAS, Novosibirsk, Russia

Email: vlasenkomyces@mail.ru

Russian Federation, 101 Zolotodolinskaya str., Novosibirsk, 630090, Russia

Ph.D. in Biology, Senior Researcher, Laboratory of Lower Plants

Vladimir V. Perelygin

Saint-Petersburg State and Chemical Pharmaceutical University, Saint-Petersburg, Russia

Email: vladimir.pereligin@pharminnotech.com
ORCID iD: 0000-0002-0999-5644
SPIN-code: 3128-7451
ResearcherId: AAV-6556-2020

Russian Federation, 197376, Russia, St. Petersburg, Professor Popov str., 14, letter A;

Doctor  of  Medicine (MD),  Professor,  Head  of  the  Industrial Ecology Department

Igor S. Figurin

Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia

Email: info@medinstitut.org

Russian Federation, 195271, Russia, St. Petersburg, Kondratyevsky Prospekt, 72 letter " A»

Ph.D. in Medicine, Associate Professor, Head of the Department of Infectious Diseases, Phthisiology, Dermatovenerology and Medical and Preventive Disciplines

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