Life Path of Professor Elena Pavlovna Yakovleva (1938-2023)

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Abstract

This essay describes the life path of Professor Elena Pavlovna Yakovleva, a Doctor of Biological Sciences, who headed the Biotechnology Department at the St. Petersburg Chemical Pharmaceutical Academy from 1993 to 2013. Elena Pavlovna is the author of over 30 inventions, more than 180 publications in leading Russian and international scientific journals, a co-author of the monograph "Regulation of the biosynthesis of biologically active substances," and the textbook "Biotechnology." E.P. Yakovleva's works have been recognized with bronze awards from VDNKh of the USSR. In 2006, Elena Pavlovna Yakovleva was included in the list of top biotechnology experts published in the USA by Marquis Who's Who magazine. Elena Pavlovna Yakovleva worked at the St. Petersburg Chemical Pharmaceutical Academy until she was 80 years old. She was a talented scientist, valued and respected by her university colleagues, possessed a gentle character, high intellect, caring attitude towards staff and students, always showed interest in people's problems, and endeavored to help anyone in need of her support. We would like to express our special gratitude to Maxim Evgenievich Yakovlev, Elena Pavlovna's grandson, as well as her son and daughter-in-law, for their help in summarizing archival materials provided from the family archive.

About the authors

Vera A. Kolodyaznaya

Saint-Petersburg State Chemical and Pharmaceutical University

Author for correspondence.
Email: vera.kolodyaznaya@pharminnotech.com
SPIN-code: 8398-4350

Candidate of Biological Sciences, Associate Professor, Head of the Department of Biotechnology

Russian Federation, Санкт-Петербург

Oksana V. Topkova

Saint-Petersburg State Chemical and Pharmaceutical University

Email: oxana.topkova@pharminnotech.com
SPIN-code: 8902-3924

Candidate of Biological Sciences, Associate Professor of the Department of Biotechnology 

Russian Federation, Санкт-Петербург

Natalia V. Kotova

Saint-Petersburg State Chemical and Pharmaceutical University

Email: natalia.kotova@pharminnotech.com
SPIN-code: 6334-5550

Candidate of Chemical Sciences, Associate Professor of the Department of Biotechnology

Russian Federation, Санкт-Петербург

References

  1. Yakovleva E.P. Comparative characteristics of levorin produced on mixed cultivation of act. Levoris with other microorganisms (Russian) / E.P.Yakovleva, E.N. Sokolova // Antibiotics, Vol. 18. № 6. - 1973. - P. 485-489.
  2. Yakovleva E.P. Studies of type composition of levorin A. Composition of levorin A produced by various strains of Act.levoris / E.P. Yakovleva, V.A.Tsyganov // Antibiotics, Vol. 14.- 1969 - P. 505.
  3. Yakovleva E.P. Studies on type composition of levorin A. Biological properties of components of levorin A complex / Tsyganov V.A., Yakovleva E.P. // Antibiotics, Vol. 14. - 1969. - P. 635.
  4. Tsyganov V.A. Actinomyces fulvoviolaceus var. Achromogenes var. Nov., an organism producing fulvomycin, a new heptaenic complex / V.A.Tsyganov, E.P. Yakovleva, L.F. Kruglikova // Antibiotics, Vol. 20. № 7. - 1975. - P. 579-584.
  5. Tsyganov V.A. Comparative characteristics of some actinomycetes producing antifungal antibiotics related to chondamycin / V.A.Tsyganov, V.M. Mitskevich, E.P. Yakovleva // Antibiotics, Vol. 20. № 9. - 1975. - P 775-779.
  6. Yakovleva E.P. Parvulomycin, a new antibiotic produced by Actinomyces parvullus var. Chromogenes var. Nov. / E.P. Yakovleva, V.N. Omelchenko, V.A.Tsyganov, Yu. D. Shenin // Antibiotics, Vol. 21. № 1. -1976. - P. 38-40.
  7. Yakovleva E.P. Effect of different pH values of medium on antibiotic synthesis by Act. levoris and yeasts grown together // Antibiotics, Vol. 21. № 6. -1976. - P. 494-499.
  8. Yakovleva E.P. Formation of amphotericin B in mixed cultures / E.P.Yakovleva, T.N. Bulgakova // Pharmaceutical Chemistry Journal, Vol. 12, № 11. - 1978. - P. 1483-1488.
  9. Yakovleva E.P. Levorin biosynthesis stimulating substances and characteristic features of their production by various microorganisms / E.P.Yakovleva, O.S.Kuznetsova, V.A. Tsyganov // Antibiotics, Vol. 25. № 8. - 1980. - P. 572-576.
  10. Yakovleva E.P. Synthetic medium for biosynthesis of polyenic antibiotics, levorin and amphotericin B // Antibiotics, Vol. 25. № 11.- 1980. - P. 817-822.
  11. Yaskovich, G. A. Strain-specific variations in the hydrophobicity of the bacterial cell surface / G. A. Yaskovich, E. P. Yakovleva // Mikrobiologiya. – 1996. – Vol. 65, No. 4. – P. 569-571.
  12. Sukharevich M.E. The influence of aeration and redox potential on the biosynthesis of the antifungal antibiotic imbricin / M.E. Sukharevich, E.P. Yakovleva, O.G. Borisova, V.I. Sukharevich // Antibiotics and chemotherapy, Vol 43. No. 12. - 1998. - P. 3-9. (In Russ).
  13. Yakovleva E.P. Standardization of the composition of nutrient substrates when obtaining an antifungal antibiotic / E.P. Yakovleva, V.A. Kolodyaznaya, O.V. Topkova // Pharmacy, vol. 68, no. 5. – 2019. – P.22-26. (In Russ).
  14. Yacovleva E.P. Influence of Aryl-Substituted Xylose Derivatives on Fermentation of Antifungal Antibiotic Imbricin / E.P. Yacovleva, V.A. Kolodyaznaya, I.V. Boicova and V.V. Belakhov // Russian Journal of General Chemistry, v.88, № 13. – 2018. – P.2829-2836.
  15. Polevaya E.V. Strain-specific features in the composition and dynamics of carboxylic acids in the cultivation of bacteria Escherichia coli and Salmonella enteritidis / E.V. Polevaya, T.Ya. Vakhitov, E.P. Yakovleva // KubGAU journal, vol. 33, No. 77. – 2012. – pp.1-8. (In Russ).
  16. Topkova O.V. Activity of carbohydrate metabolism enzymes Streptomyces imbricatus - imbricin producer in the process of regulation of antibiotic biosynthesis / O.V. Topkova, E.P. Yakovleva, V.A. Kolodyaznaya // Antibiotics and chemotherapy, T. 55. No. 3-4. - 2010. - P. 3-7. (In Russ).
  17. Topkova O.V. Study of the biosynthesis of the non-polyene antibiotic imbricin on a medium containing the filtrate of the producer’s culture fluid / O.V. Topkova, E.P. Yakovleva, G.A. Yaskovich // Antibiotics and chemotherapy, No. 45. - 2000. - P. 5-10. (In Russ).
  18. Belakhov V.V. Non-medical antifungal antibiotic imbricin: preparation, physicochemical properties, structural features and application in industry and agriculture (review) / V.V. Belakhov, E.P. Yakovleva, V.A. Kolodyaznaya, I.V. Boykova // Ecological Chemistry, T. 26. No. 5. - 2017. - P. 233-248. (In Russ).
  19. Kolodyaznaya V.A. A new source for obtaining the enzyme superoxide dismutase / V.A. Kolodyaznaya, E.P. Yakovleva // Pharmacy, No. 8. - 2015. - P. 26-28. (In Russ).
  20. Patent No. 712439 USSR, C12 D 13/10 Strain Streptomyces saraceticus var. Cerasus var. Nov. - producer of phospholipase C inhibitor: declared 08/14/1978: published 01/30/1980 / Yakovleva E.P., Polyak M.S., Tereshin I.M., Mazunina Zh.D. and etc.; applicant VNIITIAF. – 2 pp., ill. (In Russ).
  21. Copyright certificate SU 908798 A1 Method for obtaining phospholipase C inhibitor: application No. 2877340 dated 12/05/1979: published 02/28/1982 / Rozhanskaya T.I., Averyanova E.V., Andreeva T.V., Zherlitsyna V.N., Selezneva A.A., Yakovleva E.P., Polyak M.S., Myasnikova L.G., Mazunina Zh.D., Fateeva L.I., Tereshin I.M.; applicant VNIITIAF. (In Russ).
  22. Copyright certificate SU 839545 A1 Strain - lactamase inhibitor producer; application No. 2764099 dated 05/07/1979; published 06.23.1981 / Mazunina Zh.D., Yakovleva E.P., Prokopenko V.M., Rozhanskaya T.I., Konev Yu.E., Polyak M.S., Tereshin I.M., Belousova I. AND.; applicant VNIITIAF. (In Russ).
  23. Patent for invention RU 2054479 C1 Method for obtaining a complex of amylolytic and proteolytic enzymes: application No. 93007647/13 dated 02/08/1993: published 02/20/1996 / Dembrovskaya E.M., Kuznetsova O.S., Yakovleva E.P., Luknitskaya O.F., Zobnina I.A., Selezneva A.A., Artemyeva N.G., Sinyavina O.S. ; applicant VNIITIAF. (In Russ).
  24. Kolodyaznaya V.A. Regulation of the biosynthesis process of biologically active substances / V.A. Kolodyaznaya, O.V. Topkova, E.P. Yakovleva. – Moscow, Knoruss Publishing House, 2019. – 141 p. (In Russ).
  25. Biotechnology: textbook / ed. V.A. Kolodyaznoy, M.A. Samotruev. – Moscow, GEOTAR-Media, 2020. – 384 p.: ill. – doi: 10.33029/9704-5436-7-VTN-2020-1-384. (In Russ).

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