The state of cancer care in Russia: lymphomas, non-Hodgkin's lymphoma (C82-85). Part 2. Age-related features of patient survival (clinical and population study).



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Abstract

This study evaluated the effectiveness of treatment for Non-Hodgkin Lymphomas (NHL, C82-85) based on an analysis of patient survival. The results demonstrate significant progress in the treatment of NHL, particularly among children, adolescents, and young adults. Throughout the study period, a positive trend in survival rates was observed, with higher values noted in women. Analysis of survival in different age groups revealed their specific characteristics. An improved distribution of patients across disease stages and survival levels was demonstrated. A detailed examination of survival by NHL subtypes allowed for the establishment of differences in prognosis for various nosological forms. The presented results contribute to the understanding of modern epidemiology and outcomes of NHL, and also emphasize the need for further development of personalized treatment approaches and improved access to medical care for patients with different subtypes of this disease.

About the authors

Vakhtang M. Merabishvili

N. N. Petrov National Medical Research Centre of Oncology Ministry of public health of Russian Federation

Email: MVM@niioncologii.ru
ORCID iD: 0000-0002-1521-455X
SPIN-code: 5705-6327

Honored Scientist of the Russian Federation, Dr.Med.Sci., Professor, Head of the Department of Cancer Statistics

Russian Federation, Saint Petersburg

Svetlana A. Kuleva

N. N. Petrov National Medical Research Centre of Oncology Ministry of public health of Russian Federation; Saint Petersburg State Pediatric Medical University

Author for correspondence.
Email: Kulevadoc@yandex.ru

DSc Med., Associate Professor, Leading Researcher at the Scientific Department of Innovative Methods of Therapeutic Oncology and Rehabilitation, Head of the Pediatric Oncology Department, Professor of the Educational and Methodological Department N. N. Petrov National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation; Head of the Department of Oncology, Pediatric Oncology and Radiation Therapy at the St. Petersburg State Pediatric Medical University of the Ministry of Health of the Russian Federation; Chief Freelance Pediatric Oncologist at the Committee on Public Health

Russian Federation, Saint Petersburg

Alexey M. Belyaev

N. N. Petrov National Medical Research Centre of Oncology Ministry of public health of Russian Federation; North-Western State Medical University named after I. I. Mechnikov

Email: bam281060@yandex.ru

Dr. Med. Sci., Professor, Honored Doctor of the Russian Federation, Corresponding Member of RAS, Director of the N. N. Petrov National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation; Head of the Department of Oncology, North-Western State Medical University named after I.I. Mechnikov

Russian Federation, Saint Petersburg; Saint Petersburg

Larisa V. Filatova

N. N. Petrov National Medical Research Centre of Oncology Ministry of public health of Russian Federation

Email: larisa_filatova@list.ru

Dr. of Sci. (Med.), Associate Professor, Leading Researcher of the Research Department of Innovative Therapeutic Oncology and Rehabilitation Methods, Oncologist of the Department

Russian Federation, Saint Petersburg

Vladimir V. Perelygin

Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation

Email: vladimir.pereligin@pharminnotech.com
ORCID iD: 0000-0002-0999-5644
SPIN-code: 3128-7451
Scopus Author ID: 13105602000
ResearcherId: AAV-6556-2020

Dr.Med.Sci., Professor, Head of the Industrial Ecology Department

Russian Federation, Saint Petersburg

References

  1. Malignant tumors in Russia in 2022 (morbidity and mortality) / Ed. A.D. Kaprina, V.V. Starinskogo, A.O. Shakhzadova, I.V. Lisichnikovoi. – M.: P.A. Herzen MSIOI – filial of NMRC of radiology Ministry of Public Health of the Russian Federation, 2023. – 275 p. (in Russ.).
  2. WHO Classification of Tumours of Haematopoietic and Limphoid Tissues (англ.) / Swerdlow, Steven H.; Campo, Elias; Harris, Nancy Lee; Jaffe, Elaine S.; Pileri, Stefano A.; Stein, Harold; Thiele, Jurgan; Vardiman, James W.-Oxford University Press, 2008.
  3. Reference book for comparing the codes of the International Classification of Diseases of the 9th and 10th revisions by neoplasm class. / Ed. by prof. V.M. Merabishvili. - St. Petersburg, 1997. - 92s. (in Russ.).
  4. SEER Stat Fact Sheets: Non-Hodgkin Lymphoma (https://seer.cancer.gov/statfacts/html/nhl.html). NCI.
  5. Berrino F., Sant M., Verdecchia V., Capocaccia R., Hakulinen T., Estéve J., eds. Survival of cancer patients in Europe: the EUROCARE Study (IARC Scientific Publications No. 132). Lyon: International Agency for Research on Cancer, 1995.
  6. Berrino F., Capocaccia R., Coleman M.P., Esteve J., Gatta G., Hakulinen T., Micheli M., Sant M., Verdecchia V., eds. Survival of cancer patients in Europe: the EUROCARE-2 study (IARC Scientific Publications No. 151). Lyon: International Agency for Research on Cancer, 1999.
  7. Berrino F., Capocaccia R., Esteve J., Gatta G., Hakulinen T., Micheli M., Sant M., Verdecchia V., eds. EUROCARE-3: the survival of cancer patients diagnosed in Europe during 1990-94. Ann Oncol 2003; 14 (Suppl. 5): pp1–155
  8. Capocaccia R., Gavin A., Hakulinen T., Lutz J.M., Sant M. (eds.) Survival of cancer patients in Europe, 1995-2002. The EUROCARE-4 study. Eur J Cancer 2009; 45.
  9. De Angelis R., Sant M., Coleman M., Francisci S., Baili P., Pierannunzio D., Trama A., Visser O., Brenner H., Ardanaz E., Bielska-Lasota M., Engholm G., Nennecke A., Siesling S., Berrino F., Capocaccia R., and the EUROCARE-5 Working Group. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE-5—a population-based study. Lancet Oncol 2014; 15:23-34. http://dx.doi.org/10.1016/ S1470-2045(13)70546-1
  10. Black RJ, Sharp L, Kendrick SW. Trends in cancer survival in Scotland 1968-90. Edinburg. 1993:261.
  11. Ederer F. A simple method for determining standard errors of survival rates, with tables. J. Chron. Dis. N 11. 1960;11(6):632-45. doi: 10.1016/0021-9681(60)90062-x.
  12. Hakulinen T. On long-term relative survival rates. J Chronic Dis. 1977;30(7):431–43. doi: 10.1016/0021-9681(77)90036-4.
  13. Parkin DM, Hakulinen T. Cancer registration: principles and methods. Analysis of survival. IARC Sci Publ. 1991;(95):159–76
  14. Merabishvili V.M. Survival of cancer patients. St.Petersburg: KOSTA, 2011. – 330p. (in Russ.).
  15. Merabishvili V.M. Survival of cancer patients. St.Petersburg: KOSTA, 2011. – 408p. (in Russ.).
  16. Merabishvili V.M. Malignant tumors in the North-West Federal Region of Russia (morbidity, mortality, index accuracy, survival). Express-information. Fifth Issue. Editors: Prof. A.M. Belyaev, Prof. A.M. Shcherbakov. – St.Petersburg: T8 Publishing technologies, 2020. – 236p. (in Russ.).
  17. Merabishvili V.M. Malignant tumors in the North-West Federal Region of Russia (Morbidity, mortality, prevalence rate, survival). Express-information. Sixth Issue. Manual for doctors / Ed. By prof A.M. Belyaev– SPb: T8 Publishing technologies, 2023. – 485 p. (in Russ.).
  18. Berezkin DP. The study of survival and individual prognosis in malignant tumors. General oncology. Napalkov NP, ed. L. 1989:608632 (In Russ.).
  19. Kulyova SA, Gogun AA. Non-Hodgkin's lymphomas in children: clinical features, diagnostics, treatment. Pharmateka. 2018; 4:37–43. (In Russ.).

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