Recent achievements, problems and future prospects in the field of personalized bioengineering of organs and tissues



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Abstract

The article reviews current tissue engineering technologies for restoring or replacing organs and tissues. The principles, technologies, and stages of creating tissue-engineered constructs are presented. The main processes of biodegradation of tissue-engineered products after implantation are described. The most successful and promising achievements of tissue bioengineering for personalized regeneration of bronchi, myocardium and heart valves, blood vessels, skin, as well as the possibility of obtaining tissue-engineered personalized teeth are highlighted. The most promising directions for the further development of personalized bioengineering are outlined. Ethical and legal issues related to the procurement of initial donor biological material and the subsequent use of bioengineered products in patients are discussed. The presented literature sources illuminate contemporary trends and advances in the field of 3D tissue engineering and regenerative medicine, focusing on the creation of functional tissue constructs for the restoration of damaged organs.

About the authors

Alexander I. Tyukavin

Pavlov First Saint Petersburg State Medical University

Author for correspondence.
Email: alexander.tukavin@pharminnotech.com
ORCID iD: 0000-0001-5129-4414
SPIN-code: 8476-5366
Scopus Author ID: 6603645369
ResearcherId: V-6699-2017

Doctor of Medical Sciences, Professor, Professor of the Department of Pathophysiology with a course in clinical Pathophysiology

Russian Federation, Saint Petersburg

Gumar I. Kadyrov

Iona Group, an international bioinformatics Internet platform

Email: gumakad@gmail.com

Генеральный директор

Russian Federation, Санкт-Петербург

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