Investigating the effects of Inonotus rickii extracts on the muscle contraction intensity
- Authors: Ranadive K.R.1, Jagtap N.V.2, Jagtap P.N.3, Zmitrovich I.V.4, Perelygin V.V.5
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Affiliations:
- Department of Botany, P.D.E.A.’s Annasaheb Magar Mahavidyalaya, Mahadevnagar
- Department of Chemistry, P.D.E.A.’s Waghire College Saswad
- Department of Pharmacology, P.D.E.A.’s SGRS College of Pharmacy, Saswad
- Laboratory of Systematics and Geography of Fungi, Komarov Botanical Institute
- Saint Petersburg State Chemical and Pharmaceutical University
- Issue: Vol 3, No 1 (2021)
- Pages: 92-96
- Section: Biological sciences
- URL: https://journals.eco-vector.com/PharmForm/article/view/63224
- DOI: https://doi.org/10.17816/phf63224
- ID: 63224
Cite item
Abstract
The aim of this study is to test the effect of aqueous, ethereal and alcoholic extracts of the fruit bodies of the wood-destroying fungus Inonotus rickii on locomotor activity resulting from contraction of both cross-striated and smooth muscles. The pharmacological activity of I. rickii raw materials was determined in vitro using the dose-response curve method (smooth muscles) and in experiments with oral intake of extracts (CNS-mediated effects on cross-lacing muscles). The aqueous extract of fungal material showed an increase in the motor activity of smooth muscles compared to standard caffeine, which indicates the ability of fungal extract to have a stimulating effect on the synapses. It was found that I. rickii extracts have an effect on smooth muscle contraction similar to the acetylcholine. It was shown that the greatest stimulating activity demonstrates an aqueous extract that may be a result of inhibitory effect of diethyl ether and ethanol on synapses. The described effects put on the agenda both the fractionation of active extracts and further experiments on the therapeutic applications of their described properties. As a field of possible application of this kind of substances can be considered the cardiovascular remodeling, the maintenance of smooth muscle tone during a number of surgical interventions, and the palliative cure of disseminated cancers.
About the authors
Kiran Ramchandra Ranadive
Department of Botany, P.D.E.A.’s Annasaheb Magar Mahavidyalaya, Mahadevnagar
Author for correspondence.
Email: ranadive.kiran@gmail.com
ORCID iD: 0000-0001-9673-7872
Scopus Author ID: 36629222300
M.Sc., Ph.D., Associate Professor, P.D.E.A.’s Annasaheb Magar Mahavidyalaya, Mahadevnagar
India, Hadapsar, Pune-411028Neeta Vijayrao Jagtap
Department of Chemistry, P.D.E.A.’s Waghire College Saswad
Email: neetuvj7@gmail.com
M. Sci. and M. Phil., Assistant Professor
India, Taluka-Purandar, District-Pune, Pune-412301Pradnya Nilesh Jagtap
Department of Pharmacology, P.D.E.A.’s SGRS College of Pharmacy, Saswad
Email: pnj1511@gmail.com
M. Pharm., Assistant Professor, Department of Pharmacology, P.D.E.A.’s SGRS College of Pharmacy, Saswad, Taluka-Purandar
India, Taluka-Purandar, District-Pune, Pune-412301Ivan V. Zmitrovich
Laboratory of Systematics and Geography of Fungi, Komarov Botanical Institute
Email: iv_zmitrovich@mail.ru
ORCID iD: 0000-0002-3927-2527
SPIN-code: 4155-3190
ResearcherId: I-1523-2013
https://binran.ru/sotrudniki/4926/
D.Sc. in Biology, Leading Researcher, Laboratory of Systematics and Geography of the Fungi, Komarov Botanical Institute RAS
Russian Federation, St. PetersburgVladimir V. Perelygin
Saint Petersburg State Chemical and Pharmaceutical University
Email: vladimir.pereligin@pharminnotech.com
ORCID iD: 0000-0002-0999-5644
SPIN-code: 3128-7451
ResearcherId: AAV-6556-2020
Doctor of Medicine (MD), Professor, Head of the Industrial Ecology Department, Saint Petersburg State Chemical Pharmaceutical University
Russian Federation, St. PetersburgReferences
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