Course of intrahospital coronavirus infection (COVID-19) against the background of preventive and curative administration of peptide immunotropic drugs as part of complex therapy
- 作者: Petlenko S.V.1,2, Smirnov V.S.1,3, Rudenko V.V.4
-
隶属关系:
- MBSPC Cytomed, Saint Petersburg, Russia
- Toxicology, Federal Medical-Biological Agency, Saint Petersburg, Russia
- Saint-Petersburg Pasteur Institute, Saint Petersburg, Russia
- Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. Vreden, Saint Petersburg, Russia
- 期: 卷 2, 编号 3 (2020)
- 页面: 8-13
- 栏目: Pharmaceutical Sciences
- URL: https://journals.eco-vector.com/PharmForm/article/view/43135
- DOI: https://doi.org/10.17816/phf43135
- ID: 43135
如何引用文章
全文:
详细
Due to the lack of COVID-19 specific preventive measures with a prophylactic and therapeutic (as part of complex therapy) purpose, various drugs were used as humanitarian aid from manufacturing companies to prevent influenza and SARS in St. Petersburg hospitals.
The study of Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. Vreden patient treatment shows the possibility of using drugs containing a synthetic regulatory thymus peptide (L-glutamine-L-tryptophan-thymogen) as an active ingredient in a patient with an in-hospital coronavirus infection. This compound has a number of extra- and intracellular immunotropic effects of key importance in the pathogenesis of respiratory viral infections, including coronavirus etiology. The components have an indirect antiviral effect against acute respiratory viral infections, comprising COVID-19.
This led to the use of drugs containing thymogen for the prevention and treatment of COVID-19. The use of immunotropic agents promoted the rapid involution in the patient of clinical, laboratory and instrumental (radiological) signs of the disease and its uncomplicated course both in the primary infection and the development of superinfection cases. The study has shown that the use for the prevention and treatment (as part of complex therapy) of drugs with immunomodulatory activity, as well as those capable of affecting various links in the pathogenesis of pulmonary lesions in coronavirus infection, seems to be highly relevant and justified.
作者简介
Sergey Petlenko
MBSPC Cytomed, Saint Petersburg, Russia; Toxicology, Federal Medical-Biological Agency, Saint Petersburg, Russia
编辑信件的主要联系方式.
Email: petlenko@mail.ru
Scopus 作者 ID: 407034
Doctor of Medicine (MD), Head of Clinical Research Department, Leading Researcher
俄罗斯联邦, 194356, Россия, Санкт-Петербург, Орлово-Денисовский проспект, дом 14 строение 1; 192019, Россия, Санкт-Петербург, ул.Бехтерева, д.1Vyacheslav Smirnov
MBSPC Cytomed, Saint Petersburg, Russia; Saint-Petersburg Pasteur Institute, Saint Petersburg, Russia
Email: vsmirnov@cytomed.ru
SPIN 代码: 6276-2918
Scopus 作者 ID: 85597
Doctor of Medicine (MD), Professor, Department head, leading researcher
俄罗斯联邦, 194356, Россия, Санкт-Петербург, Орлово-Денисовский проспект, дом 14 строение 1; 197101, Россия, Санкт-Петербург, ул. Мира, д. 14Victor Rudenko
Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. Vreden, Saint Petersburg, Russia
Email: VictorRudenko@mail.ru
SPIN 代码: 8781-9360
Scopus 作者 ID: 423240
Ph. D. Medical Sciences, head of the neurosurgical Department
俄罗斯联邦, 195427, Россия, Санкт-Петербург, улица Академика Байкова, 8参考
- (ВОЗ) Выступление Генерального директора ВОЗ на пресс-брифинге по коронавирусной инфекции 2019-nCoV, 11 февраля 2020 г. https://www.who.int/ru/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020
- Попова А. Ю., Ежлова Е. Б., Мельникова А. А., Башкетова Н. С., Фридман Р. К., Лялина Л. В., Смирнов В. С., Чхинджерия И. Г., Гречанинова Т. А., Агапов К. А., Арсентьева Н. А., Баженова Н. А., Бацунов О. К., Данилова Е. М., Зуева Е. В., Комкова Д. В., Кузнецова Р. Н., Любимова Н. Е., Маркова А. Н., Хамитова И. В., Ветров В. В., Миличкина А. М., Дедков В. Г., Тотолян А. А. 2020. Популяционный иммунитет к вирусу sars-cov-2 среди населения Санкт-Петербурга в активную фазу эпидемии COVID-19. COVID19-preprints.microbe.ru. https://doi.org/10.21055/preprints-3111752 (в печати).
- Клиническая фармакология тимогена/ под ред. проф. В.С. Смирнова. СПб, 2012.
- Смирнов В.С., Тотолян А.А. Врожденный иммунитет при коронавирусной инфекции. Инфекция и иммунитет. 2020; vol. 10, no 2, pp.:259-268. https://doi.org/10.15789/2220-7619-III-1440"
- Смирнов В.С., Тотолян А.А. Некоторые возможности иммунотерапии при коронавирусной инфекции. Инфекция и иммунитет. 2020, Online first. https://doi.org/10.15789/2220-7619-SPO-1470
- Смирнов, В.С., Зарубаев В.В., Петленко С.В. Биология возбудителей и куонтрольгриппа и ОРВИ. СПб: Гиппократ, 2020
- Boggu P., Venkateswararao E., Manickam M. Kwak D., Kim Y., Jung S.-H.. Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB. Bioorg. med. chem. 2016, vol. 24, no. 8, pp. 1872–1878. doi: 10.1016/j.bmc.2016.03.012.
- Boopathi S., Poma A.B., Kolandaivelc P. Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment J. Biomol. Struct. Dyn. 2020 : 1–10. doi: 10.1080/07391102.2020.1758788
- Bowie A.G., O'Neill L.A.J. Vitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kinase. J. Immunol. 2000, vol. 165, p. 7180–7188. doi: 10.4049/jimmunol.165.12.7180.
- Machhi J., Herskovitz J., Senan A.M., Dutta D., Nath B., Oleynikov M.D., Blomberg W.R., Meigs D.D., Hasan M., Patel M., Kline P., Chang R.C.-C., Chang L., Gendelman H.E., Kevadiya B.D. The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections. J. Neuroimmune Pharmacol. 2020, pp. 1–28. doi: 10.1007/s11481-020-09944-5
- Мaxim A. Shevtsov, Larisa V. Smagina, Tatiana A. Kudriavtceva, Sergey V. Petlenko, Irina V. Voronkina. / Glu-Trp-ONa or its acylated analogue (R- Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wound in rabbits / - Drug Design, Development and Therapy. – 2015/9. - p.1717-1727
- Smirnov V.S., Savelyev S.A., Petlenko S.V., Redlich G., Erofeeva M.K., Lyovina A.V., Zaviyalova N.I./ Comparative efficacy and safety of preventive treatment with cytovir-3 and arbidol in children during seasonal outbreak of respiratory viral infection (an open-label randomized clinical study)/ Russian Journal of Infection and Immunity, 2019, vol.9, no.2, pp.273-278.
- Thevarajan I., Nguyen T.H.O., Koutsakos M., Druce J., Caly L., van de Sandt C.E., Jia X., Nicholson S., Catton M., Cowie B., Tong S.Y.C., R S.. Lewin , Katherine Kedzierska Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 Nature Medicine 2020. https://doi.org/10.1038/s41591-020-0819-2
补充文件
![](/img/style/loading.gif)