Modeling and assaying seizure activity in zebrafish (Danio rerio)
- Authors: Galstyan D.S.1,2,3, Kolesnikova T.O.4, Kositsyn Y.M.1, Zabegalov K.N.4, Gubaidullina M.A.4, Maslov G.O.4,5, Demin K.A.1,4,3, Kalueff A.V.1,2,4,3,5,6,7,8
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Affiliations:
- Saint Petersburg State University
- A.M. Granov Russian Research Center for Radiology and Surgical Technologies
- Almazov National Medical Research Centre
- Sirius University of Science and Technology
- Ural Federal University
- Novosibirsk State University
- Research Institute of Neuroscience and Medicine
- Moscow Institute of Physics and Technology
- Issue: Vol 20, No 2 (2022)
- Pages: 193-199
- Section: Original articles
- Submitted: 09.08.2022
- Accepted: 12.08.2022
- Published: 03.10.2022
- URL: https://journals.eco-vector.com/RCF/article/view/109708
- DOI: https://doi.org/10.17816/RCF202193-199
- ID: 109708
Cite item
Abstract
Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.
Keywords
Full Text
About the authors
David S. Galstyan
Saint Petersburg State University; A.M. Granov Russian Research Center for Radiology and Surgical Technologies; Almazov National Medical Research Centre
Email: david_sam@mail.ru
ORCID iD: 0000-0002-6213-5117
Research Associate
Russian Federation, Saint Petersburg; Saint Petersburg; Saint PetersburgTatyana O. Kolesnikova
Sirius University of Science and Technology
Email: philimontani@yandex.ru
ORCID iD: 0000-0002-5561-8583
SPIN-code: 8558-7887
Research Associate
Russian Federation, SochiYurii M. Kositsyn
Saint Petersburg State University
Email: ikosicin53@gmail.com
ORCID iD: 0000-0002-4266-808X
Research Associate
Russian Federation, Saint PetersburgKonstantin N. Zabegalov
Sirius University of Science and Technology
Email: hatokiri@mail.ru
ORCID iD: 0000-0002-9748-0324
SPIN-code: 5993-6315
Research Associate
Russian Federation, SochiMariya A. Gubaidullina
Sirius University of Science and Technology
Email: mariangub@gmail.com
Research Associate
Russian Federation, SochiGleb O. Maslov
Sirius University of Science and Technology; Ural Federal University
Email: maslovog6@gmail.com
Research Associate
Russian Federation, Sochi; YekaterinburgKonstantin A. Demin
Saint Petersburg State University; Sirius University of Science and Technology; Almazov National Medical Research Centre
Email: deminkasci@gmail.com
SPIN-code: 3830-1853
Cand. Sci. (Biol.), Senior Research Associate
Russian Federation, Saint Petersburg; Sochi; Saint PetersburgAllan V. Kalueff
Saint Petersburg State University; A.M. Granov Russian Research Center for Radiology and Surgical Technologies; Sirius University of Science and Technology; Almazov National Medical Research Centre; Ural Federal University; Novosibirsk State University; Research Institute of Neuroscience and Medicine; Moscow Institute of Physics and Technology
Author for correspondence.
Email: avkalueff@gmail.com
ORCID iD: 0000-0002-7525-1950
SPIN-code: 4134-0515
Dr. Sci. (Biol.), Professor
Russian Federation, Saint Petersburg; Saint Petersburg; Sochi; Saint Petersburg; Yekaterinburg; Novosibirsk; Novosibirsk; MoscowReferences
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