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Antihypoxic activity and anti-ischemic effect of complex herbal remedy
- Authors: Gulyaev S.M.1, Zhalsanov Y.V.2, Turtueva T.A.1, Nikolaeva G.G.1
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Affiliations:
- Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences
- Regional Clinical Veteran Hospital
- Issue: Vol 20, No 3 (2022)
- Pages: 325-330
- Section: Phytopharmacology and Phytotherapy
- URL: https://journals.eco-vector.com/RCF/article/view/109729
- DOI: https://doi.org/10.17816/RCF203325-330
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Abstract
The present study was carried out to determine the antihypoxic and anti-ischemic effects of a polyherbal extract from Astragalus membranaceus, Scutellaria baicalensis and Phlojodicarpus sibiricus. The Wistar rats of both sexes were used in the study. The antihypoxic activity of the extract was studied using hemic and hypobaric models of hypoxia. The anti-ischemic effect of the extract was evaluated by the severity of neurological deficit and survival within 24 hours in model of bilateral occlusion of the common carotid arteries.
The course administration of the extract (100, 200 mg/kg) had an antihypoxic effect in the model of hemic hypoxia: the reserve time of life increased by 26 and 28%, respectively, compared with the control. The course introduction of the extract at doses of 50, 100 and 200 mg/kg increased the reserve time of life in hypobaric hypoxia by 12.3, 15.5 and 16.7%, respectively, compared with the control
The administration of the extract (100 and 200 mg/kg) in the model of cerebral ischemia had a cerebroprotective effect: the indicators of neurological deficit were, respectively, less than the control by 34 and 46%, and their survival was 62 and 64%, respectively, against 20% of the survival of rats in the control group. The results of the conducted studies suggest the prospects for further study of the plant extract as a cerebroprojector agent.
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About the authors
Sergey M. Gulyaev
Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences
Email: s-gulyaev@bk.ru
ORCID iD: 0000-0001-8412-5799
Cand. Sci. (Med.), Senior Research Associate of the Laboratory of Experimental Pharmacology
Russian Federation, 6, Cakhyanovoi st., Ulan-Ude, 670047Yuriy V. Zhalsanov
Regional Clinical Veteran Hospital
Email: zhalsanoff@yandex.ru
Chief, Department of Neurology
Russian Federation, 6, Cakhyanovoi st., Ulan-Ude, 670047Tatiana A. Turtueva
Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences
Email: ryabchikova.taty@mail.ru
Post-graduate Student
Russian Federation, 6, Cakhyanovoi st., Ulan-Ude, 670047Galina G. Nikolaeva
Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: g-g-nik@mail.ru
Dr. Sci. (Pharm.), Leading Research Associate
Russian Federation, 6, Cakhyanovoi st., Ulan-Ude, 670047References
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