Experimental approaches to modeling delirium in zebrafish (Danio rerio)
- Authors: Maslov G.O.1,2, Kolesnikova T.O.1, Zabegalov K.N.1, Kalueff A.V.1,2,3,4,5,6,7,8
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Affiliations:
- Sirius University of Science and Technology
- Ural Federal University
- Saint Petersburg State University
- A.M. Granov Russian Research Center for Radiology and Surgical Technologies
- Almazov National Medical Research Centre
- Novosibirsk State University
- Research Institute of Neuroscience and Medicine
- Moscow Institute of Physics and Technology
- Issue: Vol 20, No 2 (2022)
- Pages: 177-183
- Section: Original articles
- Submitted: 11.08.2022
- Accepted: 12.08.2022
- Published: 03.10.2022
- URL: https://journals.eco-vector.com/RCF/article/view/109738
- DOI: https://doi.org/10.17816/RCF202177-183
- ID: 109738
Cite item
Abstract
Delirium is an acute psychiatric syndrome characterized by impaired attention, perception and orientation in space. Albeit known for millennia, the mechanisms and risk factors of delirium remain poorly understood. Experimental animal models, especially rodents, become widely used to understand these pathogenetic aspects. However, a new model organism — zebrafish (Danio rerio) also has promise in this field. Discussed here, recent behavioral tests and protocols for zebrafish enable assessing their behavioral and cognitive function, and its experimental modulation by deliriant drugs and other factors.
Keywords
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About the authors
Gleb O. Maslov
Sirius University of Science and Technology; Ural Federal University
Email: maslovog6@gmail.com
Research Associate
Russian Federation, Sochi; YekaterinburgTatyana O. Kolesnikova
Sirius University of Science and Technology
Email: philimontani@yandex.ru
ORCID iD: 0000-0002-5561-8583
SPIN-code: 8558-7887
Research Associate
Russian Federation, SochiKonstantin N. Zabegalov
Sirius University of Science and Technology
Email: hatokiri@mail.ru
ORCID iD: 0000-0002-9748-0324
SPIN-code: 5993-6315
Research Associate
Russian Federation, SochiAllan V. Kalueff
Sirius University of Science and Technology; Ural Federal University; Saint Petersburg State University; A.M. Granov Russian Research Center for Radiology and Surgical Technologies; Almazov National Medical Research Centre; Novosibirsk State University; Research Institute of Neuroscience and Medicine; Moscow Institute of Physics and Technology
Author for correspondence.
Email: avkalueff@gmail.com
ORCID iD: 0000-0002-7525-1950
SPIN-code: 4134-0515
Dr. Sci. (Biol.), Professor
Russian Federation, Sochi; Yekaterinburg; Saint Petersburg; Saint Petersburg; Saint Petersburg; Novosibirsk; Novosibirsk; MoscowReferences
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