The influence of the extract of Panax ginseng on the behavior of chronically alcoholized Danio rerio during ethanol withdrawal

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BACKGROUND: The search for new ways to correct the pathophysiological mechanisms underlying the alcohol withdrawal syndrome is an urgent and promising direction in the pharmacotherapy of alcoholism. The extract of Panax ginseng is of interest in relation to the correction of pathological behaviors caused by long-term alcohol consumption. With the help of behavioral tests, you can evaluate the features of various forms of behavior.

AIM: To study the effect of Panax ginseng extract solution on the behavior of Danio rerio fish during the period of alcohol withdrawal after prolonged alcoholization.

MATERIALS AND METHODS: Prolonged alcoholization was modeled by placing the fish in an aquarium with 0.3 ethanol solution for 14 days. After the abolition of ethanol, intraperitoneal injections of Panax ginseng root extract solution (0.3 mg / 1 g) were performed for 7 days. The behavior of fish was studied in the test “Motor activity in a new place and after habituation”.

RESULTS: The article presents the results of the effect of Panax ginseng extract solution on the behavior of Danio rerio fish during the period of alcohol withdrawal after prolonged alcoholization. The time spent in sections in the Panax ginseng (0.3 mg / 1 g) injection group was restored to control levels compared to the alcohol withdrawal group of fish injected with saline.

CONCLUSIONS: The study showed that the behavior of Danio rerio fish in the test “Motor activity in a new place and after habituation” was subject to changes, while the Panax ginseng extract recover the behavioral changes of the fish up to control indexes.

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About the authors

Marat I. Airapetov

St. Petersburg State Pediatric Medical University; Institute of Experimental Medicine

Author for correspondence.
ORCID iD: 0000-0002-8318-9069
SPIN-code: 5982-4075

Cand. Med. Sci. (Pharmacology), Senior Researcher

Russian Federation, Saint Petersburg; Saint Petersburg

Sergei O. Eresko

Institute of Experimental Medicine; St. Petersburg State Chemical Pharmaceutical University

ORCID iD: 0000-0002-0269-6078
SPIN-code: 4096-2798

Junior Research Assistant

Russian Federation, Saint Petersburg; Saint Petersburg

Anna N. Galustyan

St. Petersburg State Pediatric Medical University

ORCID iD: 0000-0001-9679-632X
SPIN-code: 3303-7650

Cand. Med. Sci. (Infectious diseases), Head of the Department

Russian Federation, Saint Petersburg

Andrei A. Lebedev

Institute of Experimental Medicine

ORCID iD: 0000-0003-0297-0425
SPIN-code: 4998-5204

Dr. Biol. Sci. (Pharmacology), Professor, Head of the Laboratory

Russian Federation, Saint Petersburg

Petr D. Shabanov

Institute of Experimental Medicine

ORCID iD: 0000-0003-1464-1127
SPIN-code: 8974-7477

Dr. Med. Sci. (Pharmacology), Professor and Head of the Department

Russian Federation, Saint Petersburg


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Copyright (c) 2022 Airapetov M.I., Eresko S.O., Galustyan A.N., Lebedev A.A., Shabanov P.D.

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