The possibilities of chiral drugs

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Abstract

In world practice, most drugs are chiral compounds, and about 90% of the latter are synthesized as racemates, which consist of an equimolar mixture of two enantiomers. Despite the fact that they have the same chemical structure, most of the isomers of chiral drugs show noticeable differences in safety and efficacy: pharmacology, toxicology, pharmacokinetics, metabolism.

The aim of our study is to analyze the literature data concerning the nomenclature, pharmacology, toxicology and mechanisms of action of currently used chiral drugs.

The analysis revealed the need to develop a method of chiral separation and analysis of racemic drugs in the pharmaceutical industry. This process plays a particularly important role in the clinic, to exclude an undesirable isomer from the drug from the point of view of pharmacotherapy, as well as to select the optimal course of treatment and maximum pharmacological effect.

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About the authors

Karina V. Lenskaya

Saint Petersburg State University; St. Petersburg State Chemical and Pharmaceutical University

Email: karinavl@yandex.ru
ORCID iD: 0000-0002-6407-0927

Dr. Sci. (Biol.), Professor and Head of the Department

Russian Federation, Saint Petersburg; Saint Petersburg

Ruslan A. Kurbanov

St. Petersburg State Pediatric Medical University

Email: ruslan_kra@mail.ru

Assistant

Russian Federation, Saint Petersburg

Georgii O. Bagaturiya

St. Petersburg State Pediatric Medical University

Email: geobag@mail.ru

Dr. Sci. (Med.), Professor and Head of the Department

Russian Federation, Saint Petersburg

Vladimir V. Grishin

Lesgaft National State University of Physical Education, Sport and Health; I.P. Pavlov St. Petersburg State Medical University

Email: w.grischin@yandex.ru
ORCID iD: 0000-0002-3759-8611
SPIN-code: 3452-7882

PhD (Pharmacology), Associate Professor

Russian Federation, Saint Petersburg; Saint Petersburg

Sergei N. Proshin

Herzen State Pedagogical University of Russia

Author for correspondence.
Email: psnjsn@rambler.ru
ORCID iD: 0000-0001-9720-4381
SPIN-code: 2978-4545

Dr. Med. Sci. (Morphology and Pharmacology), Professor

Russian Federation, Saint Petersburg

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