Probiotics: Review of the current state of the problem from the standpoint of clinical pharmacology and evidence-based medicine

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Abstract

The use of antibiotics in the treatment of various diseases dramatically changes the quantitative and qualitative compositions of both pathogenic and symbiotic microbiota. Oral and parenteral use of antibacterial drugs affects and changes the quantitative and qualitative compositions of the intestinal microbiota, which subsequently entails changes in the cell development and long-term violations of physiology at all levels of functioning of the macroorganism. This study analyzed available data on modern probiotic drugs, which help improve the normal microbiota in the human body. The results revealed the undoubted effectiveness of various probiotics in acute and antibiotic-associated diarrhea and eradication of Helicobacter pylori.

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About the authors

Andrey V. Pavlysh

North-Western State Medical University named after I.I. Mechnikov

Email: andrei.pavlysh@szgmu.ru
ORCID iD: 0000-0002-7617-5822
SPIN-code: 5785-8324

MD, Dr. Sci. (Medicine)

Russian Federation, Saint Petersburg

Tatiana Yu. Galunova

N.N. Petrov National Medical Research Centre of Oncology

Email: galunovaeyu@mail.ru
ORCID iD: 0000-0002-4588-6496
SPIN-code: 3244-5406
Russian Federation, Saint Petersburg

Dmitrii A. Kachanov

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: Dmitrii.Kachanov@szgmu.ru
ORCID iD: 0000-0003-1528-1899
SPIN-code: 4912-7511
Russian Federation, Saint Petersburg

Galina Ya. Lapkina

North-Western State Medical University named after I.I. Mechnikov

Email: Galina.Lapkina@szgmu.ru
SPIN-code: 4967-2337

канд. мед. наук

Russian Federation, Saint Petersburg

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