Probiotics: Review of the current state of the problem from the standpoint of clinical pharmacology and evidence-based medicine

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Abstract

The use of antibiotics in the treatment of various diseases dramatically changes the quantitative and qualitative compositions of both pathogenic and symbiotic microbiota. Oral and parenteral use of antibacterial drugs affects and changes the quantitative and qualitative compositions of the intestinal microbiota, which subsequently entails changes in the cell development and long-term violations of physiology at all levels of functioning of the macroorganism. This study analyzed available data on modern probiotic drugs, which help improve the normal microbiota in the human body. The results revealed the undoubted effectiveness of various probiotics in acute and antibiotic-associated diarrhea and eradication of Helicobacter pylori.

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About the authors

Andrey V. Pavlysh

North-Western State Medical University named after I.I. Mechnikov

Email: andrei.pavlysh@szgmu.ru
ORCID iD: 0000-0002-7617-5822
SPIN-code: 5785-8324

MD, Dr. Sci. (Medicine)

Russian Federation, Saint Petersburg

Tatiana Yu. Galunova

N.N. Petrov National Medical Research Centre of Oncology

Email: galunovaeyu@mail.ru
ORCID iD: 0000-0002-4588-6496
SPIN-code: 3244-5406
Russian Federation, Saint Petersburg

Dmitrii A. Kachanov

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: Dmitrii.Kachanov@szgmu.ru
ORCID iD: 0000-0003-1528-1899
SPIN-code: 4912-7511
Russian Federation, Saint Petersburg

Galina Ya. Lapkina

North-Western State Medical University named after I.I. Mechnikov

Email: Galina.Lapkina@szgmu.ru
SPIN-code: 4967-2337

канд. мед. наук

Russian Federation, Saint Petersburg

References

  1. Kaibysheva VO, Nikonov EL. Probiotics from the standpoint of evidence-based medicine. Russian Journal of Evidence-Based Gastroenterology. 2019;8(3):45–54. EDN: LFBVJW doi: 10.17116/dokgastro2019803145
  2. Suez J, Zmora N, Segal E, Elinav E. The pros, cons, and many unknowns of probiotics. Nat Med. 2019;25(5):716–729. doi: 10.1038/s41591-019-0439-x
  3. Kim SK, Guevarra RB, Kim YT, et al. Role of probiotics in human gut microbiome-associated diseases. J Microbiol Biotechnol. 2019;29(9):1335–1340. doi: 10.4014/jmb.1906.06064
  4. Piqué N, Berlanga M, Miñana-Galbis D. Health benefits of heat-killed (tyndallized) probiotics: an overview. Int J Mol Sci. 2019;20(10):2534. doi: 10.3390/ijms20102534
  5. Tkachenko EI, Skazkavaeva EV, Avalueva EB, Sitkin SI. Saccharomyces boulardii (Enterol®) in the practice of the therapist and gastroenterologist. Gastroenterologiya Sankt-Peterburga. 2010;(1):23–24. EDN: YMCEJA (In Russ.)
  6. Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics. 2014;134(1): e176–e191. doi: 10.1542/peds.2013-3950
  7. Hojsak I, Fabiano V, Pop TL, et al. Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups. Acta Paediatr. 2018;107(6):927–937. doi: 10.1111/apa.14270
  8. Stetsiouk ОU, Andreeva IV. The evidence base and practical approaches to probiotic use in clinical practice: a focus on Lactobacillus rhamnosus GG and Bifidobacterium lactis Вb-12. Clinical Microbiology and Antimicrobial Chemotherapy. 2019;21(2):100–118. EDN: QVNQAE doi: 10.36488/cmac.2019.2.100-118
  9. Ruchkina IN, Fadeeva NA. The role of a combined probiotic in the treatment of lactase deficiency. Terapevticheskii Arkhiv. 2021;93(4): 431–434. EDN: YOITWO doi: 10.26442/00403660.2021.04.200808
  10. Sugyan NG, Zakharova IN. Bac-Set multiprobiotic: results of Russian and foreign clinical research. Medical Council. 2017;(19): 104–110. EDN: ZQTKXL doi: 10.21518/2079-701X-2017-19-104-110
  11. Ushkalova EA. Current views on the role of probiotics in the prevention and treatment of different diseases: Focus on Linex. Terapevticheskii Arkhiv. 2014;86(4):117–124. EDN: SVPGZJ
  12. Kornienko EA, Saburova AV. The experience of using l. Acidophilus probiotic in the complex therapy of gastroduodenitis with the syndrome of excessive bacterial growth. Children Infections. 2018;17(3):46–50. EDN: XYUJPF doi: 10.22627/2072-8107-2018-17-3-46-50
  13. Ushkalova EA, Gushchina YuSh. Linex forte in the prevention and treatment of gastrointestinal diseases. Terapevticheskii Arkhiv. 2015;(12): 138–144. EDN: VKWGVJ doi: 10.17116/terarkh20158712138-144
  14. Videlock EJ, Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2012;35(12): 1355–1369. doi: 10.1111/j.1365-2036.2012.05104.x
  15. Saturio S, Nogacka AM, Alvarado-Jasso GM, et al. Role of Bifidobacteria on infant health. Microorganisms. 2021;9(12):2415. doi: 10.3390/microorganisms9122415
  16. Kazemi A, Noorbala AA, Azam K, et al. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clin Nutr. 2019;38(2):522–528. doi: 10.1016/j.clnu.2018.04.010

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