THE ULCEROGENIC EFFECT OF NON-STEROID ANTI-INFLAMMATORy DRUGS AND HEPATOTOXICITy OF NIMESULIDE IN EXPERIMENT ON RATS

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Abstract

In animal experimental model the ulcerogenic effect of non-selective and selective inhibitors of cyclooxigenase has been estimated. The all tested remedies influenced morphology of liver and mucosa of stomach. Meanwhile the reaction of each animal on non-steroidal anti-inflammatory drugs was individual. It has been elucidated that ketorolac significantly down-regulated prostaglandin E2 production in gut mucosa. Nimesulide (selective non-steroidal anti-inflammatory drug) significantly up-regulated the activity of aspartat-aminotransferase in serum of experimental rats. The mechanism of nimesulide hepatotoxicity is being discussed.

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About the authors

Sergei Nikolayevich Proshin

I. I. Mechnikov North-West State Medical University

Email: psnjsn@rambler.ru
D.Sci. (Pharmacology), Associate Professor (Dozent), Department of Pharmacology

Valerii Gennad’evich Makarov

Joint-stock company “Institute of Pharmacy of St.Petersburg”

D.Sci. (Pharmacology), Direktor-Generale

Marina Nikolaevna Makarova

Joint-stock company “Institute of Pharmacy of St.Petersburg”

D.Sci. (Pharmacology), Deputy of Direktor-Generale

Kirill Leonidovich Kryshen

Joint-stock company “Institute of Pharmacy of St.Petersburg”

Senior researcher (Biochemistry)

Artem Viktorovich Kovshin

I. I. Mechnikov North-West State Medical University, St.Petersburg

assistant, Department of Pharmacology

Igor Alekseevich Samusenko

Joint-stock company “Institute of Pharmacy of St.Petersburg”

Ph.D. (Pathological Anatomy)

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Copyright (c) 2012 Proshin S.N., Makarov V.G., Makarova M.N., Kryshen K.L., Kovshin A.V., Samusenko I.A.

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