Wound healing effect benzosulfonate 1-ethyl-3-methyl-4,5-bis(n-methylcarbamoyl) imidazolium

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Abstract


Materials and methods. In experiments on 180 male rats weighing 180–200 g, the wound-healing effect of derivatives of imidazole (IEM-1181) was evaluated as a 10% ointment on models of aseptic full-layer linear and planar skin wounds.

Results. It was found that the compound IEM-1181 in the form of 10% ointment has a pronounced on skin wound healing effect, manifested in the qualitative features of the regenerative healing process. With local application of the ointment containing the tested compound, the strength of the tissue formed on the site of a full-layer linear skin wound was increased when its edges were stretched, and the healing time of full-layer planar wounds was reduced. The morphological picture of the tissue formed at the site of the wound defect corresponded to complete healing by primary tension with complete epithelization of the surface and squamous cell differentiation of the epithelial regenerate without signs of inflammation and scar formation.

Conclusion. The results of the study on experimental models of full-layer linear and planar skin wounds indicate that the wound healing effect of the tested ointment is due to the anti-inflammatory activity of the IEM-1181 compound


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About the authors

Lydmila K. Khnychenko

Institute of Experimental Medicine

Author for correspondence.
Email: ludmila.konst83@mail.ru

Russian Federation, Saint Petersburg

PhD, Dr. Biol. Sci. (Pharmacology), Leading Reasercher, S.V. Anichkov Department of Neuropharmacology

Elena N. Selina

Institute of Experimental Medicine

Email: ludmila.konst83@mail.ru

Russian Federation, Saint Petersburg

Scientific Associate, S.V. Anichkov Department of Neuropharmacology

Olga M. Rodionova

Institute of Experimental Medicine

Email: ludmila.konst83@mail.ru

Russian Federation, Saint Petersburg

PhD, Scientific Associate, S.V. Anichkov Department of Neuropharmacology

Levon B. Piotrovskiy

Institute of Experimental Medicine

Email: levon-piotrovsky@yandex.ru

Russian Federation, Saint Petersburg

Dr. Biol. Sci., Professor, S.V. Anichkov Department of Neuropharmacology

Petr D. Shabanov

Institute of Experimental Medicine

Email: pdshabanov@mail.ru

Russian Federation, Saint Petersburg

Dr. Med. Sci. (Pharmacology), Professor and Head, Dept. of Neuropharmacology

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Copyright (c) 2020 Khnychenko L.K., Selina E.N., Rodionova O.M., Piotrovskiy L.B., Shabanov P.D.

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