Potential use of Kalanchoe plants in the development of innovative drug products: a review of chemical composition and pharmacological properties

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Abstract

Plants of the genus Kalanchoe have a long history of use in traditional medicine owing to their anti-inflammatory, wound-healing, and antimicrobial properties. However, many species remain insufficiently studied, which opens opportunities for expanding their pharmacological potential and identifying new therapeutic properties. This paper presents a systematic review and analysis of up-to-date information on the chemical composition and biological activity of various species of the genus Kalanchoe. The study includes a review of scientific publications reporting a wide range of active components, including alkaloids, triterpenes, glycosides, flavonoids, steroids, bufadienolides, lipids, and organic acids. Examples of evidence-based studies confirming their presence are provided. The article discusses the role of herbal medicines in modern society and their advantages over synthetic drugs. Such remedies exert a mild effect on the human body, have a long-lasting therapeutic effect, are well tolerated, have few contraindications, and demonstrate high biological activity. The study emphasizes the importance of further pharmaceutical and biological evaluation of Kalanchoe species. This is necessary for the development of safe and effective novel herbal drugs that can help to advance medicine and the pharmaceutical industry.

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About the authors

Lev O. Solomatin

Kirov Military Medical Academy

Author for correspondence.
Email: solomatin2112@mail.ru
ORCID iD: 0009-0001-6586-7516
SPIN-code: 3504-7155
Russian Federation, 6 Zh Akademika Lebedeva st, Saint Petersburg, 194044

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