Thermal pharmacology: history and definition

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The literature review shows that temperature pharmacology is a new scientific and practical direction of pharmacology, in which the local effect of drugs on individual tissues, organs or parts of the body is realized at a certain local temperature. This trend was formed in Russia at the end of the 20th century due to the fact that such great surgeons as V.A. Negovsky, E.N. Meshalkin and V.I. Shumakov proved in clinical conditions that hypothermia prolongs the safety of the brain, heart and kidneys in the absence of arterial blood and/or oxygen. Then, under the influence of the successful use of local hypothermia for therapeutic purposes in such areas as resuscitation, transplantology and surgical treatment of heart and major vascular diseases, the study of the mechanism of action of local hypothermia as a medicine began. Intensive research in this area began in 1981 at the Department of Pharmacology of the Izhevsk Medical Institute. In the following years, the features of the local action of local hypothermia, drugs and their combinations on mitochondria, blood, blood vessels, myocardium, intestines and limbs of experimental animals and patients in normal conditions, as well as in hypoxia and ischemia were studied. Very soon, the results of research allowed to reveal the main mechanisms of action of local hypothermia and the laws of temperature dependence of the local action of drugs. This allowed to invent several original methods of pharmaco-cold and pharmaco-warm effects that increase the effectiveness of treatment of arterial obstruction of the extremities, inflammatory processes and parenchymal bleeding. It is indicated, that the main provisions of temperature pharmacology were formulated by 1988. The chronology of resolving the contradictions that arose at that time between the widespread public opinion and new ideas about the role of local temperature in the mechanism of local action of drugs in hypoxia, ischemia, inflammation of organs and tissues, and bleeding is shown. Achievements and prospects of development of temperature pharmacology in medicine, biology, pharmacology and pharmacy are shown.

Full Text

Restricted Access

About the authors

Aleksandr L. Urakov

Izhevsk State Medical Academy

Author for correspondence.
Email: urakoval@live.ru
ORCID iD: 0000-0002-9829-9463
SPIN-code: 1613-9660
Russian Federation, 281 Kommunarov str., Izhevsk, 426034

References

  1. Scheindlin S. A brief history of pharmacology. Available from: https://pubsapp.acs.org/subscribe/archive/mdd/v04/i05/html/05timeline.html.
  2. Reznikov K.M. Pharmacological vector of Rudolf Buchheim. Research Results in Pharmacology. 2019; 5(1):103–116. (In Russ.) doi: 10.3897/rrpharmacology.5.32234.
  3. Biologydictionary.net Editors. Pharmacology. 2017, June 14. Available from: https://biologydictionary.net/pharmacology/.
  4. Wikipedia.org [Internet]. Ivan Pavlov. Available from: https://en.wikipedia.org/wiki/Ivan_Pavlov.
  5. Shabanov P.D. Сontribution of N.P. Kravkov to development of the general, aged, evolutionary and clinical pharmacology (in memoriam to 150 years from the birth). Pediatrician (St. Petersburg). 2015;6(2):114–125. (In Russ.)
  6. Shabanov P.D. Prominent Russian pharmacologist N.P. Kravkov and his contribution to the world pharmacology (in memoriam to 150 years from the birth). Reviews on Clinical Pharmacology and Drug Therapy. 2015;13(2):54–71. doi: 10.17816/RCF13254-71. (In Russ.)
  7. spbgmu.ru/ru/ [Internet]. History of the department of pharmacology. Avaliable from: https://www.1spbgmu.ru/ru/obschestvennaya-zhizn/277-universitet/structura/kafedry/teoreticheskie/kafedra-farmakologii-s-kursom-klinicheskoj-farmakologii/2784-istoriya-kafedry-farmakologii. (In Russ.)
  8. John Jacob Abel. [Internet] Avaliable from: http://umhistory.dc.umich.edu/history/Faculty_History/A/Abel,_John_Jacob.html.
  9. Peper A. Aspects of the relationship between drug dose and drug effect. Dose Response. 2009;7(2):172–192. doi: 10.2203/dose-response.08-019.Peper.
  10. Urakov AL. How temperature pharmacology was formed: History in personalities. Journal of Drug Delivery & Therapeutics. 2020;10(4-s):226–231. doi: 10.22270/jddt.v10i4-s.4208.
  11. Stringer JL. Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 5 ed. McGraw-Hill; 2017.
  12. González Plaza JJ, Hulak N, Zhumadilov Z, Akilzhanova A. Fever as an important resource for infectious diseases research. Intractable Rare Dis Res. 2016;5(2):97–102. doi: 10.5582/irdr.2016.01009.
  13. Foffi G, Pastore A, Piazza F, Temussi PA. Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10–14 June 2012). Phys Biol. 2013;10(4):040301. doi: 10.1088/1478-3975/10/4/040301.
  14. Urakov AL, Kasatkin AA, Urakova NA, Ammer K. Infrared thermographic investigation of fingers and palms during and after application of cuff occlusion test in patients with hemorrhagic shoсk. Thermology International. 2014;24(1):5–10.
  15. Ogoina D. Fever, fever patterns and diseases called ‘fever’ – A review. J Infect Public Health. 2011;4(3):108–124. doi: 10.1016/j.jiph.2011.05.002.
  16. Urakov AL. Recept na temperaturu. Izhevsk: Udmurtija; 1988. 76 p. (In Russ.)
  17. Urakov AL. Osnovy klinicheskoj farmakologii. Izhevsk: Izhevskij poligrafkombinat; 1997. 164 p. (In Russ.)
  18. Urakov AL, Urakova NA, Stolyarenko AP. The “desired” temperature value in the selected area of the body is the main condition for the effectiveness of drugs. Journal of Bio innovation. 2020;9(4): 499–504. doi: 10.46344/JBINO.2020.v09i04.09.
  19. Logan SR. The origin and status of the Arrhenius equation. J Chem Educ. 1982;59(4):279. doi: 10.1021/ed059p279.
  20. Kravkov NP. Osnovy farmakologii. Izdanie 14-e. Leningrad: OGIZ; 1933. (In Russ.)
  21. Urakov AL. Thermopharmacology. The “birth” syory of the scientific direction in Russia from the first person. The Journal Of Scientific Articles Health And Education Millennium. 2014;16(4):263–265. (In Russ.)
  22. Urakov AL. The history of the formation of thermopharmacology in Russia. Uspehi sovremennogo estestvoznaniya. 2014;12:29–39. (In Russ.)
  23. Moisyuk YaG, Skvortsov AE, Reznik ON. Rehabilitation of donor organs. Direction in conservation or a new paradigm of transplantology? Russian Journal of Transplantology and Artificial Organs. 2009;11(3):17–29. (In Russ.)
  24. Urakov AL, Ushnurcev SA, Zamost’janova GB. O vlijanii gipotermii i antianginal’nyh preparatov s malonatpodobnym dejstviem na glikoliz i okislitel’noe fosforilirovanie miokarda. Farmakologija i toksikologija. 1983;46(1):51–54. (In Russ).
  25. Urakov AL. Ispol’zovanie gipotermii dlja izyskanija principial’nyh putej farmakologicheskoj zashhity miokarda ot povrezhdenija v rannij period ostroj ishemii. Bulletin of Experimental Biology and Medicine. 1984;4:512. (In Russ.)
  26. Urakov AL. Ohlazhdat’ ili nagrevat’? Priroda. 1986:9:121. (In Russ.)
  27. Urakov AL. Holod v zashhitu serdca. Nauka v SSSR. 1987;2: 63–65. (In Russ.)
  28. Urakov AL. Recept na temperaturu. Nauka i zhizn’. 1989;9: 38–42. (In Russ.)
  29. Urakov AL, Odijankov EG, Odijankov JuG, et al. Mestnaja gipotermija v lechenii ostroj neprohodimosti arterij konechnosti. Vestnik hirurgii. 1988;141(7):62–64. (In Russ.)
  30. Murav’ev MF, Odijankov EG, Urakov AL, et al. Farmakoholodovaja terapija pri tjazheloj hronicheskoj ishemii nizhnih konechnostej. Hirurgija. 1989;65(3):25–29. (In Russ.)
  31. Urakov AL. Pus solvents as new medicines with unique physical and chemical properties. Reviews on Clinical Pharmacology and Drug Therapy. 2019;17(4):89–95. (In Russ.) doi: 10.17816/RCF17489-95.
  32. Urakov AL, Gruzda AM. After the cold dynamics of the infrared image and the temperature of the palms and fingers of men are normal and under the influence of alcohol. Mezhdunarodnyj zhurnal prikladnyh i fundamental’nyh issledovanij. 2014;12:112–114. (In Russ.)
  33. Urakov A, Nasyrov M, Chernova L. How fingers became warm after cooling. Thermology International. 2015;25(3):123.
  34. Urakov A, Urakova N, Reshetnikov A. Oxygen alkaline dental’s cleaners from tooth plaque, food debris, stains of blood and pus: A narrative review of the history of inventions. J Int Soc Prev Community Dent. 2019;9(5):427–433. doi: 10.4103/jispcd.JISPCD_296_19.
  35. Urakov AL. Creation of “necessary” mixtures of baking soda, hydrogen peroxide and warm water as a strategy for modernization bleaching cleaners of ceramic. Epitőanyag – Journal of Silicate Based and Composite Materials. 2020;72(1):30–35. doi: 10.14382/epitoanyag-jsbcm.2020.6.
  36. RU Patent № 2735502. 03.11.2020. Samilina IA, Alies MYu, Urakov AL, et al. Aerosol for inhalation in obstructive bronchitis. (In Russ.) Avaliable from: https://patenton.ru/patent/RU2735502C1.
  37. Urakov AL, Urakova NA. COVID-19: What drug can be used to treat a new coronavirus disease and why. J Bio Innov. 2020;9(3): 242–252. doi: 10.46344/JBINO.2020.v09i03.02.
  38. Urakov AL. Drugs and bruises: past, present and future. Reviews on Clinical Pharmacology and Drug Therapy. 2020;18(2): 161–170. doi: 10.17816/RCF182161-170. (In Russ.)
  39. Urakov AL, Urakova NA. Hydrogen peroxide discolors blood in the cavity of the hematoma under the nail and in the skin over the bruise. Regional blood circulation and microcirculation. 2020;19(2):67–74. (In Russ.) doi: 10.24884/1682-6655-2020-19-2-67-74.
  40. Urakov AL, Kasatkin AA, Urakova NA, Urakova TV. Cold sodium chloride solution 0.9 % and infrared thermography can be an alternative to radiopaque contrast agents in phlebography. J Pharmacol Pharmacother. 2016;7(3):138–139. doi: 10.4103/0976-500X. 189675.
  41. Urakov AL. The change of physical-chemical factors of the local interaction with the human body as the basis for the creation of materials with new properties. Epitőanyag – Journal of Silicate Based and Composite Materials. 2015;67(1):2–6. doi: 10.14382/epitoanyag-jsbcm.2015.1.

Copyright (c) 2021 Urakov A.L.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 65565 от 04.05.2016 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies