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Comparative evaluation of the antistress effect of phenazepam, melatonin and their combination
- Authors: Arushanian E.B.1, Vladimirovna O.1, Beyer E.V.1
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Affiliations:
- Stavropol State Medical University
- Issue: Vol 19, No 1 (2021)
- Pages: 107-110
- Section: Short communications
- URL: https://journals.eco-vector.com/RCF/article/view/70654
- DOI: https://doi.org/10.17816/RCF191107-110
- ID: 70654
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Abstract
Phenazepam and melatonin reduce anxiety in stressed rats, and their anxiolytic effect is enhanced in combination. Melatonin also limits stress-induced increases in sympathetic activity and eliminates the dysregulatory effect of phenazepam on the main indicators of heart rate variability.
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About the authors
Eduard B. Arushanian
Stavropol State Medical University
Author for correspondence.
Email: eduard.arush@mail.ru
SPIN-code: 5122-3123
Dr. Med. Sci. (Pharmacology), Professor
Russian Federation, 310 Mira str., Stavropol, 355017Olga Vladimirovna
Stavropol State Medical University
Email: kaminskaya.olga2014@yandex.ru
SPIN-code: 8878-1121
Russian Federation, 310 Mira str., Stavropol, 355017
Eduard Vladimirovich Beyer
Stavropol State Medical University
Email: karokris@mail.ru
SPIN-code: 3411-1334
professor
Russian Federation, 310 Mira str., Stavropol, 355017References
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- Arushanian EB, Beyer EV. Melatonin (biologiya, farmacologiya, klinika). Stavropol: ARGUS; 2015. 396 p. (In Russ.)
- Otmani S, Demazieres A, Staner C, et al. Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers. Hum Psychopharmacol. 2008;23(8):693–705. doi: 10.1002/hup.980
- Kaminskaya OV, Beyer EV, Arushanian EB. Assessment of the action of melatonin and fluoxetin on the model of resinpina depression. Medical News of North Caucasus. 2017;12(2):180–183. (In Russ.). doi: 10.14300/mnnc.2017.12050
