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Antistress properties of 2-substituted derivatives of quinazoline-4(3Н)-on
- Authors: Manvelyan M.M.1, Manvelyan E.A.2, Baturin V.A.1, Chagarova S.A.2
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Affiliations:
- Stavropol State Medical University
- North-Caucasian Federal University
- Issue: Vol 19, No 1 (2021)
- Pages: 115-118
- Section: Short communications
- Submitted: 15.05.2021
- Accepted: 15.05.2021
- Published: 21.05.2021
- URL: https://journals.eco-vector.com/RCF/article/view/70658
- DOI: https://doi.org/10.17816/RCF191115-118
- ID: 70658
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Abstract
2-Substituted hydroxy- and methoxyphenyl derivatives of quinazoline-4(3Н)-on at doses of 0.1 and 0.2 of molecular weight in mg/kg reduce the emotional reactivity of rats, having an anti-stressant effect when tested in a “raised cruciform labyrinth”, “open field”, in a multivariable assessment of behavior.
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About the authors
Mikael M. Manvelyan
Stavropol State Medical University
Author for correspondence.
Email: mik.manvelyan@mail.ru
post-graduate fellow
Russian Federation, 310 Mira str., Stavropol, 355017Eleonora A. Manvelyan
North-Caucasian Federal University
Email: manveljan@rambler.ru
SPIN-code: 2706-3609
Dr. Sci. (Pharm.)
Russian Federation, StavropolVladimir A. Baturin
Stavropol State Medical University
Email: stav.clin.pharm@mail.ru
SPIN-code: 4015-4401
Dr. Med. Sci. (Pharmacology), Professor
Russian Federation, 310 Mira str., Stavropol, 355017Saniyat A. Chagarova
North-Caucasian Federal University
Email: chagarovas@gmail.com
PhD (Biology)
Russian Federation, StavropolReferences
- Bunyatyan ND, Vasiliev AN, Verstakova OL, et al. Rukovodstvo po provedeniyu doklinicheskikh issledovany lekarstvennykh sredstv. Mironov AN, editor. Moscow: Grif i K; 2012. (In Russ.)
- Kodonidi IP, Oganesyan ET, Ryabukhin YuI, et al. Synthesis and biological activity of 1,4-dihydro-4-oxopyrimidine N-heterocyclic derivatives. Questions of biological, medical and pharmaceutical chemistry. 2012;(4):19–27. (In Russ.)
- Manvelyan ЕА, Manvelyan MМ, Codоnidi IP, Oganesyan ET. Аnalgesic activity of new derivatives of quinazolinone-4. Medical News of North Caucasus. 2017;12(3):307–311. doi: 10.14300/mnnc.2017.12089.
- Manvelyan EA, Manvelyan MM, Oganesyan ET, Kodonidi IP. Antihypoxant effect of hydroxy and methoxyphenyl derivatives of quinazolin-4(3H)-one. Experimental and clinical pharmacology. 2019;82(4): 16–19. (In Russ.) doi: 10.30906/0869-2092-2019-82-4-16-19.
- Manvelyan EA, Baturin VA, Kolodychuk YeV. Gendernye razlichiya v effektivnosti psikhotropnykh i kardiotropnykh lekarstvennykh sredstv. Stavropol: SKFU; 2016. 134 p. (In Russ.)
