Neurochemical mechanisms of the cerebroprotective action of spiro[indole-3,1'-pyrrol [3,4-с] pyrrol] derivative



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Abstract

The mechanisms of the neuroprotective effect of 3,2’-spiro-pyrrolo-2-оxindole derivative (code number R-86) were investigated in hippocampal sections of rats by measuring the amplitude of postsynaptic potentials in pyramidal neurons. In vitro R-86 reduced the responces to NMDA-receptors activation as well as hydrogen peroxide-induced injury, being not active in anoxia and neuroglycopenia. When systemically administered, R-86 exerted weak effect in anoxia and neuroglycopenia and decreased steroid-induced neurotoxicity.

About the authors

Ol'ga Vital'yevna Khodakovskaya

Vinnytsa National Medical University named after N.I. Pirogov of Ministry of Healthcare of Ukraine

Email: aleksey.hodakovskiy@bk.ru
PhD-student

Dmitriy Vladimirovich Evdokimov

National Medical University named after M. Gorky of Ministry of Healthcare of Ukraine

Email: evdokimov.dmit@yandex.ru
candidate of medical science, docent

Sergey Yur'yevich Shtrygol'

National University of Pharmacy MPH of Ukraine

Email: shtrygol@mail.ru
doctor of medical science, professor

Igor' Igorevich Abramets

National Medical University named after M. Gorky of Ministry of Healthcare of Ukraine

Email: abrametz2009@yandex.ua
doctor of medical science, professor

Leonid Borisovich Braverman

Vinnytsia regional psychoneurological hospital of Akkad. And. I. Yushchenko

Email: leonidbraverman@gmail.com
psychiatrist of city dispensary office

Aleksey Anatol'yevich Khodakovskiy

Vinnytsa National Medical University named after N.I. Pirogov of Ministry of Healthcare of Ukraine

Email: aleksey.hodakovskiy@bk.ru
candidate of medical science, docent

Ruslan Grigor'yevich Red'kin

National University of Pharmacy MPH of Ukraine

Email: shtrygol@mail.ru
candidate of pharmaceutical science, docent

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Copyright (c) 2015 Khodakovskaya O.V., Evdokimov D.V., Shtrygol' S.Y., Abramets I.I., Braverman L.B., Khodakovskiy A.A., Red'kin R.G.

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