Neurochemical mechanisms of the cerebroprotective action of spiro[indole-3,1'-pyrrol [3,4-с] pyrrol] derivative

  • Authors: Khodakovskaya O.V.1, Evdokimov D.V.2, Shtrygol' S.Y.3, Abramets I.I.2, Braverman L.B.4, Khodakovskiy A.A.1, Red'kin R.G.3
  • Affiliations:
    1. Vinnytsa National Medical University named after N.I. Pirogov of Ministry of Healthcare of Ukraine
    2. National Medical University named after M. Gorky of Ministry of Healthcare of Ukraine
    3. National University of Pharmacy MPH of Ukraine
    4. Vinnytsia regional psychoneurological hospital of Akkad. And. I. Yushchenko
  • Issue: Vol 13, No 1 (2015)
  • Pages: 56-61
  • Section: Articles
  • URL: https://journals.eco-vector.com/RCF/article/view/734
  • DOI: https://doi.org/10.17816/RCF13156-61
  • Cite item

Abstract


The mechanisms of the neuroprotective effect of 3,2’-spiro-pyrrolo-2-оxindole derivative (code number R-86) were investigated in hippocampal sections of rats by measuring the amplitude of postsynaptic potentials in pyramidal neurons. In vitro R-86 reduced the responces to NMDA-receptors activation as well as hydrogen peroxide-induced injury, being not active in anoxia and neuroglycopenia. When systemically administered, R-86 exerted weak effect in anoxia and neuroglycopenia and decreased steroid-induced neurotoxicity.

About the authors

Ol'ga Vital'yevna Khodakovskaya

Vinnytsa National Medical University named after N.I. Pirogov of Ministry of Healthcare of Ukraine

Email: aleksey.hodakovskiy@bk.ru
PhD-student

Dmitriy Vladimirovich Evdokimov

National Medical University named after M. Gorky of Ministry of Healthcare of Ukraine

Email: evdokimov.dmit@yandex.ru
candidate of medical science, docent

Sergey Yur'yevich Shtrygol'

National University of Pharmacy MPH of Ukraine

Email: shtrygol@mail.ru
doctor of medical science, professor

Igor' Igorevich Abramets

National Medical University named after M. Gorky of Ministry of Healthcare of Ukraine

Email: abrametz2009@yandex.ua
doctor of medical science, professor

Leonid Borisovich Braverman

Vinnytsia regional psychoneurological hospital of Akkad. And. I. Yushchenko

Email: leonidbraverman@gmail.com
psychiatrist of city dispensary office

Aleksey Anatol'yevich Khodakovskiy

Vinnytsa National Medical University named after N.I. Pirogov of Ministry of Healthcare of Ukraine

Email: aleksey.hodakovskiy@bk.ru
candidate of medical science, docent

Ruslan Grigor'yevich Red'kin

National University of Pharmacy MPH of Ukraine

Email: shtrygol@mail.ru
candidate of pharmaceutical science, docent

References

  1. Абрамец И. И., Евдокимов Д. В., Талалаенко А. Н. и др. Центральная глутаматергическая синаптическая передача при поведенческой депрессии у крыс // Нейронауки: теор. та клiн. аспекти. - 2006. - Т. 2, № 1-2. - C. 22-30.
  2. Багаурі О. В., Редькін Р. Г., Ходаківський О. А. Скринінг антигіпоксичної активності в ряду нових похідних 3,2’-спіро-пірроло-2-оксіндолу // Вісник фармації. - 2013. - № 2 (74). - С. 63-65.
  3. Петрик И. А., Ходаковская О. В., Штриголь С. Ю., Ходаковский А. А. Модулирующее действие производного 3,2'-спиро-пирроло-2-оксиндола на формирование стероидной нейротоксичности, кардиоцеребральной дисфункции и течение нейроапоптоза в условиях экспериментального ишемического инсульта // Врач-аспирант. - 2014. - № 6 (67). - С. 44-53.
  4. Рекомендации по ведению больных с ишемическим инсультом и транзиторными ишемическими атаками. Исполнительный комитет Европейской инсультной организации (ESO) и авторский комитет ESO // Практична ангіологія. - 2008. - № 4. - С. 9-23.
  5. Соболева Е. Л. О возможных путях профилактики реперфузии при критических состояниях // Сибирский медицинский журнал. - 2012. - № 1. - С. 13-16.
  6. de Almeida L. M., Leite M. C., Tomazi A. P. et al. Rosveratrol protects against oxidative injury induced by H2O2 in acute hippocampal slice preparations from Wistar rats // Arch. Biochem. Biophys. - 2008. - Vol. 480, N 1. - P. 27-32.
  7. Duncan J., Johnson S., Ou X.-M. Monoamine oxidases in major depressive disorder and alcogolism // Drug Discov. Therap. - 2012. - Vol. 6, N 3. - P. 112-122.
  8. Gaetz M. The neurophysiology of brain injury // Clin. Neurophysiol. - 2004. - Vol. 115, N 1. - P. 4-18.
  9. Haynes L. E., Striffits M. R., Hyde R. E., et al. Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregion of the striatum and hippocampus; implication for mood disorders // Neuroscience. - 2001. - Vol. 104, N 1.- P. 57-69.
  10. Kim J. J., Diamond D. M. The stressed hippocampus, synaptic plasticity and lost memories // Nat. Rev. Neurosci. - 2002. - Vol. 3, N 4. - P. 453-462.
  11. de Kloet E. R. Stress in the brain // Eur. J. Pharmacol. - 2000. - Vol. 405, N 2. - P. 187-198.
  12. Liu Y., Wong T. P., Aarts M. et al. NMDA receptor subunits have differential roles in mediating exitotoxic neuronal death in vitro and in vivo // J. Neurosci. - 2007. - Vol. 27. - N 11, P. 2846-2857.
  13. Smith M. A., Makino S., Kvetnansky R. et al. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus // J. Neurosci. - 1995. - Vol. 15, N 3. - P. 1768-1777.
  14. Tian G.-F., Baker A. J. Protective effect of high glucose against ischemia-induced synaptic transmission damage in rat hippocampal slices // J. Neurophysiol. - 2002. - Vol.88, N 2. - P. 236-248.
  15. Yamamoto B. K., Reagan L. P. The glutamatergic system in neuronal plasticity and vulnerability in mood disorders // Neuropsychiatr. Dis. Treat. - 2006. - Vol.2, N 1. - P.7-14.

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Copyright (c) 2015 Khodakovskaya O.V., Evdokimov D.V., Shtrygol' S.Y., Abramets I.I., Braverman L.B., Khodakovskiy A.A., Red'kin R.G.

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