Structure, functions of p-glycoprotein and its role in rational pharmacotherapy



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Abstract

In the review of literature, the structure and functions of P-glycoprotein are characterized, features of its substrates, inductors and inhibitors and possibility of forecasting of belonging to them new medicinal substances are described, molecular mechanisms of activity changes of the transporter under the influence of various factors are presented.

About the authors

Elena Nikolaevna Yakusheva

Ryazan State Medical University

Email: e.yakusheva@rzgmu.ru
M. D., associate professor, head of the chair of pharmacology with a course of pharmacy and pharmacotherapy of faculty of additional professional education

Aleksey Vladimirovich Shulkin

Ryazan State Medical University

Email: alekseyshulkin@rambler.ru
Ph. D., assistant of the chair of pharmacology with a course of pharmacy and pharmacotherapy of faculty of additional professional education

Natal’ya Mikhaylovna Popova

Ryazan State Medical University

Email: p34-66@yandex.ru
Ph. D., assistant of the chair of pharmacology with a course of pharmacy and pharmacotherapy of faculty of additional professional education

Ivan Vladimirovich Chernyh

Ryazan State Medical University

Email: ivchernykh88@mail.ru
assistant of the chair of the general chemistry with a course of bioorganic and organic chemistry

Dmitriy Sergeevich Titov

Ryazan State Medical University

Email: i3762@yandex.ru
graduate student of the chair of pharmacology with a course of pharmacy and pharmacotherapy of faculty of additional professional education

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Copyright (c) 2014 Yakusheva E.N., Shulkin A.V., Popova N.M., Chernyh I.V., Titov D.S.

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