Kisspeptins in physiology and pathology of sex development - new diagnostic and therapeutic approaches

Abstract


The article is dedicated to mechanisms of the human reproductive system development mechanisms. The evolution of the opinions on that processes was analysed. The review of modern knowledge of molecular and genetic causes of sex development, new mechanisms of gonadal axis regulation and role of kisspeptins in pubertat start and sexual differentiation of the brain are presented. The new actual directions of scientific research as well as the applications of kisspeptin drugs for new therapeutic approaches, treatment of hormone-dependent diseases and abnormalities of sex developmentare are observed.

Irina Leorovna Nikitina

Almazov Federal Medical Recearch Centre

Dr. Med. Sci., Professor, Chief Doctor, Centre of Neonatology

Alekber Azizovich Bayramov

Almazov Federal Medical Recearch Centre

Email: alekber@mail.ru
Dr. Med. Sci., Deputy Director, Institute of Endocrinology

Yuliya Nikolaevna Khoduleva

Almazov Federal Medical Recearch Centre

Fellow, Centre of Neonatology

Petr Dmitriyevich Shabanov

Almazov Federal Medical Recearch Centre

Email: pdshabanov@mail.ru
Dr. Med. Sci., Professor, Leading Researcher, Institute of Endocrinology

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