Redox regulation as a platform for search and design of new type drugs. Search of gastroprotectors among sunstituted coumarins



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Abstract

Redox homeostasis controls most or all processes of normal and pathological physiology. Important position in the defence mechanisms are redox active metabolites As a robust platform for the development of new effective drugs is not screened, but directed the design and search for low molecular weight metabolites natural redox active compounds. This statement confirms the synthesis and study of new gastroprotektors of complex compounds of copper and zinc with coumarin ligands. On the model of acute ethanol rat gastric ulcer shown that preprocessing all tested complex compounds in equimolar doses of 0.15 mmol/kg leads to a considerable reduction in the size of the damage to the wall of the stomach, compared to control, and sucralfat (for 72,5-87,9 %, sucralfat - 52,3%).

About the authors

Edgar Andreevich Parfenov

Russian Cancer Research Center RAMS

Email: phcao@yandex.ru
PhD (Bioorganic Chemistry), Leading Researcher

Vladimir Alexandrovich Trapkov

All-Russian Scientific Center on Safety of Biologically Active Compounds

Email: vnc@pc-club.ru
PhD, Scientific Researcher

Petr Dmitriyevich Shabanov

S. M. Kirov Military Medical Academy

Email: pdshabanov@mail.ru
Dr. Med. Sci. (Pharmacology), Professor and Head, Dept. of Pharmacology

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