Predictive markers of the efficacy of colon adenocarcinoma treatment by 5-fluoropyrimidines determined by means of immunohistochemistry method



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Abstract

5-fluorouracil (5-FU) has remained the treatment of choice in the adjuvant and palliative setting of colon cancer (CC).The purpose of this study was to evaluate the expression of the thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPYD)in CC patients treated with 5-fluorouracil (5-FU) to determine their predictive and prognostic significance. Immunohistochemistry (IHC) analysis of the expression of proteins was performed on tumour tissue of 104 patients with stage IV colon cancer. All patient was treated withfluoropyrimidine/antifolate-based therapy (FOLFOX, De Gramont, FOLFIRI). Usedmultivariate logistic regression analyses we found the level of expression of proteins thymidine phosphorylase (TP), thymidylate synthase (TS) as predictors efficiency 5 - fluoropyrimidine with adenocarcinoma of the colon. The value of expression of TP and TS has a statistically significant effect (p = 0,006 and p = 0.0036) on time to disease progression, respectively.Our data demonstrated the efficacy of the 5-fluoropyrimidine chemotherapy colon adenocarcinoma may be utilized evaluation of expression of TS and TP.

About the authors

Grigoriy Aleksandrovich Raskin

Russian Research Centre for Radiology and Surgical Technologies

Email: rasking@list.ru
MD, PhD, chief researcher

Rashida Vakhidovna Orlova

Saint Petersburg State University

M.D., PhD, Dsc, professor, Head of Oncology department

Anna Eduardovna Protasova

Saint Petersburg State University

M.D., PhD, Dsc, professor of Oncology department

Sergey Aleksandrovich Koshkin

Saint Petersburg State University

resident of Oncology, Medical Faculty

Ruslan Ivanovich Glushakov

Kirov Military Medical Academy

Email: glushakovruslan@gmail.com
Ph.D., senior assistant chief of the division of scientific investigation

References

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Copyright (c) 2014 Raskin G.A., Orlova R.V., Protasova A.E., Koshkin S.A., Glushakov R.I.

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