Mechanisms and triggers of adaptation to hypoxia

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Abstract

It is believed that hypoxia-induced factor (HIF1) is the key mediator of oxygen metabolism. It was first identified as a transcription factor activated in cells and tissues by lowering the partial pressure of oxygen (O2). The HIF1 activator spectrum includes both external factors – hypoxia, psycho-emotional stress and in ternal factors and varies from hormones to iron chelators. This review is dedicated to the molecular mechanisms of HIF1 activation, some of its natural activators HIF1, the potential for which is due to the low level of toxicity and the reduced likelihood of undesirable side effects. In turn, this opens up new options to treat diseases associated with local and general ischemia and hypoxia, the possibilities of their prophylactic use for researchers and clinicians in order to reduce the degree of damage in the event of an unforeseen condition of acute injurious to organs and tissues by hypoxia and reperfusion after it.

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About the authors

Andrey V. Lyubimov

Institute of Experimental Medicine; S.M. Kirov Military Medical Academy

Email: lyubimov_av@mail.ru
ORCID iD: 0000-0001-9829-4681

PhD (Med.)

Russian Federation, 12 Academika Pavlova str., 197376, Saint Petersburg; 6, Acad. Lebedeva street, Saint Petersburg, 194044

Dmitriy V. Cherkashin

Institute of Experimental Medicine; S.M. Kirov Military Medical Academy

Author for correspondence.
Email: cherkashin-dmitr@mail.ru
ORCID iD: 0000-0003-1363-6860
SPIN-code: 2781-9507

Doctor of Medical Sciences

Russian Federation, 12, Acad. Pavlov Street, Saint-Petersburg, 197376; 6, Acad. Lebedeva street, Saint Petersburg, 194044

Semen V. Efimov

Military Medical Academy. S. M. Kirov

Email: sve03@rambler.ru
ORCID iD: 0000-0002-0384-3359
SPIN-code: 6351-6823

PhD, Cand. Sci. (Med.)

Russian Federation, 6, Acad. Lebedeva street, Saint Petersburg, 194044

Andrey E. Alanichev

Military Medical Academy. S. M. Kirov

Email: alanichevae80@mail.ru
ORCID iD: 0000-0002-4135-5815

PhD, Cand. Sci. (Med.)

Russian Federation, 6, Acad. Lebedeva street, Saint Petersburg, 194044

Valeriy S. Ivanov

Military Medical Academy. S. M. Kirov

Email: ivanovmed84@mail.ru
SPIN-code: 1965-4741

Senior Clinic Resident

Russian Federation, 6, Acad. Lebedeva street, Saint Petersburg, 194044

Gennadiy G. Kutelev

Military Medical Academy. S. M. Kirov

Email: gena08@yandex.ru
ORCID iD: 0000-0002-6489-9938
SPIN-code: 5139-8511

PhD, Cand. Sci. (Med.)

Russian Federation, 6, Acad. Lebedeva street, Saint Petersburg, 194044

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Copyright (c) 2021 Lyubimov A.V., Cherkashin D.V., Efimov S.V., Alanichev A.E., Ivanov V.S., Kutelev G.G.

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