Retina photosensitivity indexes as an objective indicator of expression of psychostimulating effect

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Abstract

BACKGROUND: The variety of neurotransmitter systems providing photoreceptor capabilities of the retina is a prerequisite for studying the retinotropic properties of some psychotropic drugs, taking into account their ability to interfere with the work of synapses.

MATERIALS AND METHODS: Given this circumstance, a set of studies was carried out with the participation of volunteers to assess the effect of psychotropic substances with a stimulating (caffeine, piracetam, Bilobil®) type of action on the functional state of the retina, recorded by the campimetric method. In the course of the research, the photosensitivity of the retina, its ability to distinguish colors and the speed of the visual-motor reaction were assessed. Such an approach can not only demonstrate the interest of retinal cellular elements in the action of substances, but also broaden the question of the participation of the visual system in the psychopharmacological effect.

RESULTS: The function of the retina was studied both in healthy volunteers and in individuals with organic lesions of the central nervous system, which were often accompanied by emotional disorders, which were identified using special questionnaire tests. It was found that these pathological conditions are accompanied by a limitation of the photosensitivity of the retina of varying severity. These facts can be interpreted in different ways. On the one hand, violations of visual functions can lead to psychoemotional disorders and be a pathogenetic link in their development, and on the other hand, primary disorders of retinal light and color sensitivity can provoke the development of psychopathology. However, regardless of the pharmacological characteristics of the studied drugs that stimulate mental activity, the relationship of their effect with changes in visual function seems obvious, which makes it possible to raise the question of the advisability of taking into account the light and color sensitivity of the retina for a comprehensive assessment of both the mental state and the pharmacodynamics of the drugs, stimulating mental activity.

CONCLUSION: Thus, it is legitimate to conclude that taking into account the light and color sensitivity of the retina can be one of the quantitative criteria for the severity and effectiveness of psychopharmacotherapy.

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About the authors

Karen B. Ovanesov

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: ovanesov2007@mail.ru

Dr. Med. Sci. (Pharmacology)

Russian Federation, 6, Academika Lebedeva str., Saint Petersburg, 194044

Petr D. Shabanov

S.M. Kirov Military Medical Academy

Email: pdshabanov@mail.ru
ORCID iD: 0000-0003-1464-1127

Dr. Med. Sci. (Pharmacology), Professor

Russian Federation, 6, Academika Lebedeva str., Saint Petersburg, 194044

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