Dark cytotoxicity of submicrometer vaterite particles loaded with photosensitizer Fotoditazin and the vaterite-based core – shells structures

Cover Page

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Photodynamic therapy (PDT) is based on the use of photosensitizers together with a light at the wavelength corresponding to its absorption maximum. Photosensitizers are able to generate reactive oxygen species under the visible or infrared light irradiation. They are broadly used for the treatment of cancer and infections due to their physical and chemical properties. Dose-dependent light induced cytotoxicity of photosensitizers shows the strong relation between its concentration in the treatment area and PDT efficiency. With this regard, the development of novel carriers for targeted delivery of photosensitizers is a very prospective research direction, as allows for the enhancement of the local drug concentration in the treatment area and the reduction of the incidental dark toxicity in healthy tissue associated with a classic PDT. Mesoporous vaterite particles are considered as a promising tool for biomedical application due to their biodegradability, high payload ability, as well as to the simplicity and cheapness of their fabrication. The efficiency of vaterite carrier application for a PDT delivery system design has been previously demonstrated. With this regard, the current study was aimed at the evaluation of dark cytotoxicity of the submicron vaterite particles and the vaterite-based core-shells, both loaded with Fotoditazin® photosensitizer.

Full Text

Restricted Access

About the authors

Roman A. Verkhovskii

Chernyshevsky Saratov National Research State University; Gagarin Saratov State Technical University

Author for correspondence.
Email: r.a.verhovskiy@mail.ru
ORCID iD: 0000-0003-1830-4582
SPIN-code: 2171-3872

Junior scientific researcher

Russian Federation, 83, Astrakhanskaya str., Saratov, 410012; 77, st. Polytechnic, Saratov, 410054

Olga V. Nechaeva

Gagarin Saratov State Technical University

Email: olgav.nechaeva@mail.ru
ORCID iD: 0000-0003-3331-1051
SPIN-code: 9984-9594

Dr. Sci. (Biol.)

Russian Federation, 77, st. Polytechnic, Saratov, 410054

Olga I. Guslyakova

Chernyshevsky Saratov National Research State University

Email: olga.gusliakova17@gmail.com
ORCID iD: 0000-0001-8387-0711
SPIN-code: 2642-9014

Scientific researcher

Russian Federation, 83, Astrakhanskaya str., Saratov, 410012

Yulia I. Svenskaya

Chernyshevsky Saratov National Research State University

Email: yulia_svenskaya@mail.ru
ORCID iD: 0000-0002-6359-2969
SPIN-code: 4546-5745

Cand. Sci. (Phis. Mat.), Senior scientific researcher

Russian Federation, 83, Astrakhanskaya str., Saratov, 410012

References

  1. Abrahamse H, Hamblin MR. New photosensitizers for photodynamic therapy. Biochem J. 2016;473(4):347–364. doi: 10.1042/BJ20150942
  2. Ermakov AV, Verkhovskii RA, Babushkina IV, et al. In Vitro Bioeffects of Polyelectrolyte Multilayer Microcapsules Post-Loaded with Water-Soluble Cationic Photosensitizer. Pharmaceutics. 2020;12(7):610. doi: 10.3390/pharmaceutics12070610
  3. Tang J, Wang L, Loredo A, et al. Single-atom replacement as a general approach towards visible-light/near-infrared heavy-atom-free photosensitizers for photodynamic therapy. Chem Sci. 2020;11(26):6701–6708. doi: 10.1039/D0SC02286A
  4. Svenskaya YI, Pavlov AM, Gorin DA, et al. Photodynamic therapy platform based on localized delivery of photosensitizer by vaterite submicron particles. Colloids Surfaces B Biointerfaces. 2016;146:171–179. doi: 10.1016/j.colsurfb.2016.05.090
  5. Svenskaya Y, Gorin D, Parakhonskiy B, Sukhorukov G. Point-wise laser effect on NIH/3T3 cells impregnated with photosensitizer-loaded porous calcium carbonate microparticles. 15th Int Conf on Nanotechnology (IEEE-NANO). 2015:1513–1516. doi: 10.1109/NANO.2015.7388931
  6. Parakhonskiy BV, Haase A, Antolini R. Sub-Micrometer Vaterite Containers: Synthesis, Substance Loading, and Release. Angew Chemie Int Ed. 2012;51(5):1195–1197. doi: 10.1002/anie.201104316
  7. German SV, Novoselova MV, Bratashov DN, et al. High-efficiency freezing-induced loading of inorganic nanoparticles and proteins into micron- and submicron-sized porous particles. Sci Rep. 2018;8(1):17763. doi: 10.1038/s41598–018–35846-x
  8. Donath E, Sukhorukov GB, Caruso F, et al. Novel Hollow Polymer Shells by Colloid-Templated Assembly of Polyelectrolytes. Angew Chemie Int Ed. 1998;37(16):2201–2205. doi: 10.1002/(SICI) 1521–3773(19980904)37:16<2201::AID-ANIE2201>3.0.CO;2-E
  9. Lengert EV, Verkhovskii RA, Genina EA, et al. Mesoporous particles for transdermal delivery of the antifungal drug griseofulvin. J Phys Conf Ser. 2020;1461:012083. doi: 10.1088/1742–6596/1461/1/012083
  10. Gusliakova O, Verkhovskii R, Abalymov A, et al. Transdermal platform for the delivery of the antifungal drug naftifine hydrochloride based on porous vaterite particles. Mater Sci Eng. C. 2021;119:111428. doi: 10.1016/j.msec.2020.111428

Statistics

Views

Abstract: 66

Dimensions

Article Metrics

Metrics Loading ...

PlumX


Copyright (c) 2021 Verkhovskii R.A., Nechaeva O.V., Guslyakova O.I., Svenskaya Y.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies