Safety study of fentanyl and dexmedetomidine combination in an experimental model of respiratory failure

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Abstract

In an experimental model of respiratory failure induced by a single intraperitoneal injection of 1 LD50 of paraquat (24 mg/kg) the changes of physical activity tolerance, respiratory function parameters were studied and histomorphologic validation of experimental results was confirmed. In a model of respiratory failure the assessment of analgesic activity and toxicity of fentanyl, dexmedetomidine and their combination was made and compared with intact animals. The integral tolerance rates (therapeutic action width) were also estimated. It was shown that on the background of pulmonary pathology for each of the drugs 13-28% decrease of average lethal doses was observed. At the same time when administered in combination an average effective dose of the drugs wasn’t changed in contrast with single-drug analgesia.

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About the authors

Nikolay G. Vengerovich

State Scientific Research Test Institute of Military Medicine

Author for correspondence.
Email: nickolai@vengerovich.ru
PhD, Deputy Head Russian Federation

Mikhail A. Judin

State Scientific Research Test Institute of Military Medicine

Email: mikhail.judin@gmail.com

PhD, Assistant Professor 

Russian Federation

Yury O. Kon’shakov

SM Kirov Military Medical Academy

Email: nickolai@vengerovich.ru
Post-graduate student Russian Federation

Konstantin A. Sherbasov

SM Kirov Military Medical Academy

Email: sherbashov@gmail.com
Post-graduate student Russian Federation

Stanislav V. Gadzikovskiy

Innovative Pharmaceutical Company “Silver Pharm Ltd”

Email: nickolai@vengerovich.ru
Junior researcher Russian Federation

Olga O. Vladimirova

State Scientific Research Test Institute of Military Medicine

Email: nickolai@vengerovich.ru
PhD, Researcher Russian Federation

Irina I. Alekseeva

State Scientific Research Test Institute of Military Medicine

Email: nickolai@vengerovich.ru
Researcher Russian Federation

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Copyright (c) 2016 Vengerovich N.G., Judin M.A., Kon’shakov Y.O., Sherbasov K.A., Gadzikovskiy S.V., Vladimirova O.O., Alekseeva I.I.

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