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Correction of experimental dislipoproteinemia by the intranasal administration of an original enzyme preparation
- Authors: Klyueva N.N.1, Okunevich I.V.1, Parfenova N.S.1, Shabanov P.D.1
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Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 18, No 2 (2020)
- Pages: 155-160
- Section: Original articles
- URL: https://journals.eco-vector.com/RCF/article/view/42405
- DOI: https://doi.org/10.17816/RCF182155-160
- ID: 42405
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Abstract
The article is devoted to the experimental study of the specific pharmacological activity of the original microbial cholesterol oxidase enzyme preparation obtained from Streptomices lavendulae. In the condition of modeling dyslipoproteinemia, a pronounced alimentary hyperlipidemia in rats with the intranasal route of administration, a dose-dependent lipid-lowering effect of the domestic enzyme preparation of microbial origin of cholesterol oxidase was detected. In moderate alimentary hyperlipidemia, based on the selection of animals with a difficultly developed conditioned drinking reflex, this original preparation of cholesterol oxidase in an effective dose has a hypolipidemic effect and normalization of the serum lipoprotein spectrum. Further studies are needed to finally clarify the question of the character, efficacy and hypolipidemic action of the natural-produced cholesterol oxidase test drug in other types of animals.
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About the authors
Natalia N. Klyueva
Institute of Experimental Medicine
Author for correspondence.
Email: nnklyueva@gmail.com
PhD (Biochemistry), Researcher, Department of Biochemistry
Russian Federation, Saint PetersburgIrina V. Okunevich
Institute of Experimental Medicine
Email: irina_okunevich@mail.ru
PhD (Pharmacology), Senior Researcher
Russian Federation, Saint PetersburgNina S. Parfenova
Institute of Experimental Medicine
Email: nnklyueva@gmail.com
PhD (Biochemistry), Senior Researcher. Department of Biochemistry
Russian Federation, Saint PetersburgPetr D. Shabanov
Institute of Experimental Medicine
Email: pdshabanov@mail.ru
Dr. Med. Sci. (Pharmacology), Professor and Head, Dept. of Neuropharmacology
Russian Federation, Saint PetersburgReferences
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