Correction of experimental dislipoproteinemia by the intranasal administration of an original enzyme preparation

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Abstract


The article is devoted to the experimental study of the specific pharmacological activity of the original microbial cholesterol oxidase enzyme preparation obtained from Streptomices lavendulae. In the condition of modeling dyslipoproteinemia, a pronounced alimentary hyperlipidemia in rats with the intranasal route of administration, a dose-dependent lipid-lowering effect of the domestic enzyme preparation of microbial origin of cholesterol oxidase was detected. In moderate alimentary hyperlipidemia, based on the selection of animals with a difficultly developed conditioned drinking reflex, this original preparation of cholesterol oxidase in an effective dose has a hypolipidemic effect and normalization of the serum lipoprotein spectrum. Further studies are needed to finally clarify the question of the character, efficacy and hypolipidemic action of the natural-produced cholesterol oxidase test drug in other types of animals.


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About the authors

Natalia N. Klyueva

Institute of Experimental Medicine

Author for correspondence.
Email: nnklyueva@gmail.com

Russian Federation, Saint Petersburg

PhD (Biochemistry), Researcher, Department of Biochemistry

Irina V. Okunevich

Institute of Experimental Medicine

Email: irina_okunevich@mail.ru

Russian Federation, Saint Petersburg

PhD (Pharmacology), Senior Researcher

Nina S. Parfenova

Institute of Experimental Medicine

Email: nnklyueva@gmail.com

Russian Federation, Saint Petersburg

PhD (Biochemistry), Senior Researcher. Department of Biochemistry

Petr D. Shabanov

Institute of Experimental Medicine

Email: pdshabanov@mail.ru

Russian Federation, Saint Petersburg

Dr. Med. Sci. (Pharmacology), Professor and Head, Dept. of Neuropharmacology

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Copyright (c) 2020 Klyueva N.N., Okunevich I.V., Parfenova N.S., Shabanov P.D.

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