Gases as ingredients of medicines

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Abstract

The literature review shows that today all over the world reference books on medicines, state Pharmacopoeia, textbooks on pharmacology and pharmacy, as well as scientific articles published in pharmaceutical and pharmacological scientific journals, contain information about medicines without taking into account the presence of gases in them. The effect of each drug is historically considered on the example of the action of its main ingredient without taking into account the action of other ingredients, namely, auxiliary, formative agents and means that change the color, taste and smell of drugs. At the same time, the biological activity of the main ingredients is traditionally considered as the activity of highly purified chemical reagents with the brand “pure for analysis”. The results of a review of scientific and patent literature have shown that in natural conditions, due to high atmospheric air pressure, air gases are always present in all substances, including liquid and solid drugs, as well as human and animal body tissues. Usually, air gases remain invisible to the naked eye. It was found that the composition and quantity of gases in medicines affect their mechanical, physical, chemical and physico-chemical properties, which give the drugs a non-specific activity when applied topically. Using the example of water, solutions and tablets, it is shown how the content of gases in them changes under vacuum, low, normal and high atmospheric pressure, and how this changes their physical and chemical properties. It is shown that the regulation of the content of gases in water, solutions and tablets of medicines allows to regulate their mass, volume, specific gravity, porosity and non-specific physical and chemical activity of medicines when applied topically. It is shown that air and individual gases have biological activity, so they can determine the mechanism of action of drugs. Recipes of new medicines in which gas is an auxiliary, formative or main ingredient are given. It is proposed to include gases in the formulation of medicines, as well as to control the gas composition of medicines as an indicator of their quality and a factor of their physical and chemical activity, which can determine the type of medicines local action.

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About the authors

Aleksandr L. Urakov

Izhevsk State Medical Academy of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: urakoval@live.ru

Dr. Med. Sci., Professor, Head, Dept. of General and Clinical Pharmacology

Russian Federation, Izhevsk

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