Reactivation of chronic brucellosis infection after COVID-19 (case report)

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It has been proven that the SARS-CoV-2 virus, interacting with persistent latent pathogens in the human body, including those living in the ecosystems of the intestine, mouth and lungs, causes dysregulation of the immune system and can contribute to the reactivation of these pathogens. The authors of the article suggested this pathogenic virus can play the role of a superantigen and trigger the phenomenon of polyclonal activation of lymphocytes, due to which various clones of lymphocytes may be activated, thereby giving impetus to the reactivation of a chronic persistent infection. This article describes a clinical case of a patient who had previously undergone an effectively treated form of chronic brucellosis in history, with signs of reactivation of brucellosis infection detected after infection with the SARS-CoV-2 virus, confirmed by clinical laboratory and instrumental studies.

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About the authors

Yulduz M. Khaidarova

Al-Farabi Kazakh National University; City Rheumatology Center

Author for correspondence.
ORCID iD: 0000-0002-5475-8410

doctoral student 3 years of study

Kazakhstan, Almaty

Olga M. Lesnyak

orth-Western State Medical University named after I.I. Mechnikov

ORCID iD: 0000-0002-0143-0614
Scopus Author ID: 56769681100
ResearcherId: J-5512-2013

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg

Gaukhar M. Kurmanova

Al-Farabi Kazakh National University

ORCID iD: 0000-0002-5768-0209
Scopus Author ID: 6507474504

MD, Dr. Sci. (Med.), Professor

Kazakhstan, Almaty

Anarkul B. Kulembaeva

City Rheumatology Center

ORCID iD: 0000-0003-3513-8467

MD, Cand. Sci. (Med.)

Kazakhstan, Almaty


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Supplementary files

Supplementary Files
1. Figure. Ultrasound of the patient’s shoulder joint before (a) and after (b) treatment

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