DYNAMICS OF TOTAL CHOLESTEROL LEVELS AND ITS EFFECT ON MORTALITY IN PEOPLE OVER AGE 65 NOT RECEIVING LIPID-LOWERING THERAPY



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Abstract

Cardiovascular diseases is the leading cause of death and disability in the old people. High total cholesterol level is a proven risk factor for cardiovascular diseases and mortality in the middle-aged persons. Importance of lipid-modifying therapy in the elderly remains controversial. Many foreign researchers have noted a decrease in total cholesterol in old people, which was not associated with lipid-lowering drugs or hypolipidemic diet. Objective: describe the total cholesterol level dynamic in persons over 65 years of old throughout the 4 years of observation; evaluate the impact of level of total cholesterol on mortality of these persons. Methods. The participants were selected randomly into two age groups, 65-74 years and 75 years and older from a database of policlinic № 95 of Kolpino district of St. Petersburg (149 and 115 patients). Examination of each participant included a twofold determination of total cholesterol during the first screening in 2009, and during the second screening in 2012. Results. The decrease of total cholesterol level was not associated with the change of nutrition, taking lipid-lowering medications, changes in body weight or level of physical activity. Changes of total cholesterol level were dependent on its level at the beginning of the study. In individuals with an optimal level of total cholesterol in the beginning of the study, we found significant increase in total cholesterol levels. In the group with borderline high cholesterol level we did not identified the change of total cholesterol levels. In the group of high total cholesterol level, we detected a statistically significant reduction in total cholesterol levels. The results show that the level of total cholesterol had no effect on mortality rate.

About the authors

A V Turusheva

Clinic "Advanced medical technology"

E V Frolova

North-Western State Medical University named after I. I. Mechnikov

References

  1. Последующая деятельность по итогам второй Всемирной ассамблеи по проблемам старения // Выдержка из доклада Генерального секретаря (A/66/173). - 2011. - 20 c.
  2. Petersen L. et al. Lipid-lowering treatment to the end? A review of observational studies and RCTs on cholesterol and mortality in 80+-year olds // Age and Ageing. - 2010. - V. 39. - P. 674-680.
  3. Reynolds C. A. et al. Serum lipid levels and cognitive change in late life // Journal of the American Geriatrics Society. - 2010. - V. 58. - № 3. - P. 501-509.
  4. Ettinger W. H. et al. Lipoprotein lipids in older people. Results from the Cardiovascular Health Study // The CHS Collaborative Research Group. - Circulation. -1992. - V. 86. - № 3. - P. 858-869.
  5. Corti M. et al. Clarifying the Direct Relation between Total Cholesterol Levels and Death from Coronary Heart Disease in Older Persons // Ann. Intern. Med. -1997. - V. 126. - № 10. - P. 753-760
  6. Frost P. H., Davis B. R. et al. Serum Lipids and Incidence of Coronary Heart Disease. Findings From the Systolic Hypertension in the Elderly Program (SHEP) // Circulation. - 1996. - V. 94. - № 10. - P. 2381-2388.
  7. Upmeier E. et al. Longitudinal changes in serum lipids in older people The Turku Elderly Study 1991-2006 // Age and Ageing. - 2011. - V. 40. - № 2. - P. 280- 283.
  8. Cohen J. D. et al. Erratum for Cohen J. D. et al. 30-Year Trends in Serum Lipids among United States Adults: Results from the National Health and Nutrition Examination Surveys II, III, and 1999-2006 // The American Journal of Cardiology. - 2010. - V. 106. - № 7. - P. 969-975.
  9. Ferrara A. et al. Total, LDL and HDL Cholesterol Decrease With Age in Older Men and Women The Rancho Bernardo Study 1984-1994 // Circulation. -1997. - V. 96. - № 1. - P. 37-34.
  10. Irwin D., Schatz J. et al. Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study // The Lancet. - 2001. - V. 358. - № 9279. - P. 351-355.
  11. Фролова Е. В., Корыстина Е. М. Комплексная оценка состояния здоровья пожилого человека и возможности ее осуществления в общей врачебной практике // Российский семейный врач. - 2010. - Т. 14. - № 1. - С. 12-23.
  12. Lewington S. et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths // The Lancet. - 2001. - V. 370. - № 9602. - P. 1829-1839.
  13. Fletcher B. et al. Managing Abnormal Blood Lipids. A Collaborative Approach: Cosponsored by the Councils on Cardiovascular Nursing; Arteriosclerosis, Thrombosis, and Vascular Biology; Basic Cardiovascular Sciences; Cardiovascular Disease in the Young; Clinical Cardiology; Epidemiology and Prevention; Nutrition, Physical Activity, and Metabolism; and Stroke; and the Preventive Cardiovascular Nurses Association. AHA Scientific Statement // Circulation. - 2005. - V. 112 -№ 21. - P. 3184-3209.
  14. Всеобъемлющий глобальный механизм контроля, включающий показатели, и комплекс добровольных глобальных целей в области профилактики неинфекционных заболеваний и борьбы с ними // Пересмотренный дискуссионный документ ВОЗ (версия от 25 июля 2012 г.). Всемирная организация здравоохранения. - 2012. - 41 c.

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Copyright (c) 2014 Turusheva A.V., Frolova E.V.

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